Impaired Iron Metabolism in Anemia of Chronic Disease

2008 Fiscal Year Final Research Report

• Project/Area Number: 19591107
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Hematology
• Research Institution: Kyoto University
• Principal Investigator: KAWABATA Hiroshi Kyoto University, 医学研究科, 助教 (10329401)
• Co-Investigator(Renkei-kenkyūsha): MORI Kiyoshi 京都大学, 医学研究科, 講師 (60343232) ; TOMOSUGI Naohisa 金沢医科大学, 総合医学研究所, 教授 (80155580)
• Project Period (FY): 2007 – 2008
• Keywords: 血液内科学 / 鉄代謝

Research Abstract

慢性疾患の貧血の主な原因は鉄の利用障害とされる。最近、生体内の鉄を制御する重要な因子として肝臓由来のペプチドホルモンのhepcidinが見いだされた。我々は、様々な血液疾患や造血細胞移植前後における血清hepcidinおよび他の鉄代謝・造血関連因子を測定した。その結果は、これらの病態でみられる鉄代謝異常にhepcidinが重要な役割を果たしていることを示した。また、造血細胞移植における血清hepcidin値や血清フェリチン値が臨床上重要な意味を持っている可能性を示した。

Research Products

• [Journal Article] Serum hepcidin level and erythropoietic activity after haematopoietic stem cell transplantation (2008)
  • Author(s): Kanda J, Mizumoto C, Kawabata H, Tsuchida H, Tomosugi N, Matsuo K and Uchiyama T.
  • Journal Title: Haematologica 93 Pages: 1550-4
• [Journal Article] Anti-interleukin 6 receptor antibody tocilizumab reduces the level of serum hepcidin in patients with multicentric Castleman's disease (2007)
  • Author(s): Kawabata H, Tomosugi N, Kanda J, Tanaka Y, Yoshizaki K and Uchiyama T.
  • Journal Title: Haematologica 92 Pages: 857-8
• [Journal Article] Clinical Significance of Serum Hepcidin Levels on Early Infectious Complications in Allogeneic Hematopoietic Stem Cell Transplantation
  • Author(s): Kanda J, Mizumoto C, Kawabata H, Ichinohe T, Tsuchida H, Tomosugi N, Matsuo K, Yamashita K, Kondo T, Ishikawa T and Uchiyama T.
  • Journal Title: Biol Blood Marrow Transplant (in press)
• [Presentation] Cause of Iron Overload-Hepcidin (2009)
  • Author(s): Kawabata H and Tomosugi N.
  • Organizer: 5th General Assembly of Asian Hematology Association-2009
  • Place of Presentation: Kobe, (Symposium)
  • Year and Date: 2009-02-19
• [Presentation] Clinical significance of serum hepcidin-25 levels on early treatment-related complications after hematopoietic stem cell transplantation (2008)
  • Author(s): Kanda J, Mizumoto C, Kawabata H, Ichinohe T, Tsuchida H, Tomosugi N, Matsuo K, Kondol T, Ishikawa T and Uchiyama T.
  • Organizer: 50th American Society of Hematology Annual Meeting and Exposition
  • Place of Presentation: San Francisco, CA (Poster)
  • Year and Date: 20081206-09
• [Presentation] 移植前血清フェリチン値が造血器腫瘍に対する同種造血幹細胞移植の成績に与える影響の検討 (2008)
  • Author(s): 水本智咲、諫田淳也、川端浩、一戸辰夫、菱澤方勝、錦織桃子、高折晃史、門脇則光、山下浩平、近藤忠一、石川隆之、内山卓
  • Organizer: 第70回日本血液学会総会
  • Place of Presentation: 国立京都国際会館, 京都
  • Year and Date: 20081010-12
• [Presentation] 造血幹細胞移植における血清ヘプシジン値と造血能 (2008)
  • Author(s): 諫田淳也、水本智咲、川端浩、内山卓、土田秀行、友杉直久、松尾恵太郎
  • Organizer: 第32回日本鉄バイオサイエンス学会学術集会
  • Place of Presentation: ホテルアラスカ(青森市)
  • Year and Date: 20080913-14
• [Presentation] 炎症性貧血におけるヘプシジンとサイトカインの関与 (2008)
  • Author(s): 川端浩
  • Organizer: 第36回臨床免疫学会イブニングセミナー
  • Place of Presentation: 東京
  • Year and Date: 2008-10-17
• [Presentation] Serum Level of Hepcidin and Erythropoietic Activity after Hematopoietic Stem Cell Transplantation (2007)
  • Author(s): Kanda J, Mizumoto C, Kawabata H, Tsuchida H, Tomosugi N, Uchiyama T.
  • Organizer: 49th Annual Meeting of the American Society of Hematology
  • Place of Presentation: Atranta, Georgia, USA, (Poster)
  • Year and Date: 20071208-11
• [Presentation] Monitoring Of Serum Hepcidin-25 In Multicentric Castleman s Disease Patients Treated With Tocilizumab, An Anti-Interleukin-6 Receptor Antibody (2007)
  • Author(s): Kawabata H, Tomosugi N, Kanda J, Mizumoto C, Tanaka Y, Ichinohe T, IKadowaki N, Ishikawa T, Yoshizaki K, Uchiyama T.
  • Organizer: 49th Annual Meeting of the American Society of Hematology
  • Place of Presentation: Atranta, Georgia, USA, (Poster)
  • Year and Date: 20071208-11
• [Presentation] シンポジウム : 鉄を起点としてがんを考える「細胞増殖とトランスフェリン受容体2」 (2007)
  • Author(s): 川端浩
  • Organizer: 第31回日本鉄バイオサイエンス学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2007-04-06
• [Presentation] ANTI-INTERLEUKIN 6 RECEPTOR ANTIBODY TOCILIZUMAB REDUCES THE LEVELS OF SERUM HEPCIDIN IN PATIENTS WITH MULTICENTRICCASTLEMAN'S DISEASE (2007)
  • Author(s): Kawabata H, Tomosugi N, Kanda J, Tanaka Y, Kadowaki N, Ichinohe T, Ishikawa T and Uchiyama T.
  • Organizer: International BioIron Society Meeting 2007
  • Place of Presentation: Kyoto Japan, (Oral presentation)
  • Year and Date: 2007-04-04
• [Presentation] THE SERUM LEVEL OF HEPCIDIN AFTER STEM CELL TRANSPLANTATION (2007)
  • Author(s): Kanda J, Mizumoto C, Kawabata H, Tomosugi N and Uchiyama T.
  • Organizer: International BioIron Society Meeting 2007
  • Place of Presentation: Kyoto Japan, (Poster)
  • Year and Date: 2007-04-04