2009 Fiscal Year Final Research Report
Functional and biological study of leukemia-associated TEL gene
| Project/Area Number |
19591135
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Ehime University (2008-2009)
Dokkyo Medical University (2007) |
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Principal Investigator |
EGUCI Minenori Ehime University, 医学部附属病院, 講師 (50420782)
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| Co-Investigator(Kenkyū-buntansha) |
EGUCHI Mariko 愛媛大学, 医学部附属病院, 講師 (40420781)
YAMAGATA Tetsuya 獨協医科大学, 医学部, 准教授 (30424047)
MAKI Kazuhiro 獨協医科大学, 医学部, 講師 (50337391)
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| Project Period (FY) |
2007 – 2009
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| Keywords | TEL / ETV6 / ES細胞 / 造血細胞分化 |
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| Research Abstract |
Murine embryonic stem (ES) cells overexpressing wild type TEL were established. The ES cells were differentiated into hematopoietic cells and were analyzed in detail to clarify its role in hematopoiesis and leukemogenesis. ES cells forced to express wild type TEL after committed to erythroid lineage produced more erythroid progenitors than control ES cells without any effects in hematopoietic cells of other lineages. When TEL gene was expressed at very early stage of hematopoiesis, more immature hematopoietic stem cells were produced than control ES cells. These results suggested that TEL might work to maintain hematopoietic cells at immature state. The precise mechanism of this effect of TEL remains to be clarified and now being investigated.
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[Journal Article] Specific JAK2 mutation (JAK2R683) and multiple gene deletions in Down syndrome acute lymphoblastic leukemia2009
Author(s)
L. Kearney, D. Gonzalez De Castro, J. Yeung, J. Procter, S.W. Horsley, M. Eguchi-Ishimae, C.M. Bateman, K. Anderson, T. Chaplin, B.D. Young, C.J. Harrison, H. Kempski, C.W. So, A.M. Ford, M. Greaves
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Journal Title
Blood 113巻3号
Pages: 646-648
Peer Reviewed
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[Journal Article] Clinical features and outcome of MLL gene rearranged acute lymphoblastic leukemia in infants with additional chromosomal abnormalities other than 11q23 translocation2008
Author(s)
H. Tauchi, D. Tomizawa, M. Eguchi, M. Eguchi-Ishimae, K. Koh, M. Hirayama, N. Miyamura, N. Kinukawa, Y. Hayashi, K. Horibe, E. Ishii
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Journal Title
Leuk Res 32巻10号
Pages: 1523-1529
Peer Reviewed
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