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2008 Fiscal Year Final Research Report

Regulation of cell growth and cytokine production in basophils

Research Project

  • PDF
Project/Area Number 19591162
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 膠原病・アレルギー・感染症内科学
Research InstitutionShinshu University

Principal Investigator

HIDA Shigeaki  Shinshu University, 医学系研究科, 助教 (10345762)

Project Period (FY) 2007 – 2008
Keywordsサイトカイン / シグナル伝達 / 好塩基球 / Th2 / インターロイキン / FcRγ / IRF
Research Abstract

近年、アレルギー反応やアレルゲンに反応する初期免疫応答における好塩基球の役割がマウスモデルで明らかになりつつあるが、好塩基球の活性化における分子機構に関して不明な点が多い。本研究課題では、これまでの好塩基球依存的な免疫制御についての成果から、好塩基球のサイトカイン産生機構や細胞増殖の分子機構について解析し、FcRγ分子を介した新規のシグナル伝達経路を同定した。

  • Research Products

    (7 results)

All 2009 2008 2007 Other

All Journal Article (3 results) (of which Peer Reviewed: 2 results) Presentation (3 results) Remarks (1 results)

  • [Journal Article] Fc receptor γ-chain, a constitutive component of the IL-3 receptor, is required for IL-3-induced IL-4 production in basophils2009

    • Author(s)
      Hida, S, Yamasaki, S, Sakamoto, Y, Takamoto, M, Obata, K, Takai, T, Karasuyama, H, Sugane, K, Saito, T, and Taki, S
    • Journal Title

      Nature mmunol 10

      Pages: 214-222

    • URL

      http://www.nature.com/ni/journal/v10/n2/abs/ni.1686.html

    • Peer Reviewed
  • [Journal Article] IL-15 inhibits pre-B cell proliferation by selectively expanding Mac-1+B220+ NK cells2008

    • Author(s)
      Nakajima, S, Hida, S, and Taki, S,
    • Journal Title

      Biochem. Biophys. Res. Commun 369

      Pages: 1139-1143

    • URL

      http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WBK-4S1JHR9-7&_user=4307883&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000050561&_version=1&_urlVersion=0&_userid=4307883&md5=96abb319aded6003c3c9719e7c5a971e

    • Peer Reviewed
  • [Journal Article] 好塩基球を介するTh2細胞の誘導2008

    • Author(s)
      肥田重明、瀧伸介
    • Journal Title

      分子細胞治療 7

      Pages: 149-155

  • [Presentation] The role of IFN-γ and IL-17 on Pneumocystis pneumonia in nude mice2008

    • Author(s)
      Hu Tao, Takamoto M, Hida S, Sugane K,
    • Organizer
      第38回日本免疫学会総会
    • Place of Presentation
      京都
    • Year and Date
      2008-12-01
  • [Presentation] Fc receptor γ-chain is a subunit of IL-3 receptor complexes, requiredfor IL-4 expression by but not proliferation of murine basophils2007

    • Author(s)
      Hida S, Yamasaki S, Saito T, Taki S,
    • Organizer
      第37回日本免疫学会総会
    • Place of Presentation
      東京
    • Year and Date
      2007-11-21
  • [Presentation] Paired immunoglobulin-like receptor(PIR)-B regulates IL-3 responces in basophils2007

    • Author(s)
      Kikuchi H, Sakamoto Y, Takai T, Hida S, Taki S
    • Organizer
      第37回日本免疫学会総会
    • Place of Presentation
      東京
    • Year and Date
      2007-11-21
  • [Remarks]

    • URL

      http://www.shinshu-u.ac.jp/faculty/medicine/department/doctor/zouki/immunol/main_frame.htm

URL: 

Published: 2010-06-10   Modified: 2016-04-21  

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