2009 Fiscal Year Final Research Report
Analysis of host cellular receptors used by measles viruses derived from subacute sclerosing panencephalitis
| Project/Area Number |
19591216
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Osaka City University |
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Principal Investigator |
AYATA Minoru Osaka City University, 大学院・医学研究科, 助教 (90222702)
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| Co-Investigator(Kenkyū-buntansha) |
ISHIDA Hiroshi 大阪市立大学, 大学院・医学研究科, 登録医 (50382081)
OHGIMOTO Shinji 大阪市立大学, 大学院・医学研究科, 准教授 (80292853)
OGURA Hisashi 大阪市立大学, 大学院・医学研究科, 教授 (10115222)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 麻疹ウイルス / 亜急性硬化性全脳炎 / レセプター / 神経病原性 / 細胞融合 |
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| Research Abstract |
Mutations found in measles viruses derived from subacute sclerosing panencephalitis (SSPE) was evaluated for the relationship to the binding activity to receptors and to the neurovirulence. Amino acid substitutions found in the F and H proteins, especially those found in the F protein, were responsible for the neurovirulence. Amino acid substitutions in the H protein affected the binding activity to the receptor(s) and a region in the H protein responsible for the binding to the unknown receptor was defined.
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