2009 Fiscal Year Final Research Report
Study of the pathogenesis of fetal brain damage due to lack of thyroid hormone.
| Project/Area Number |
19591228
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
ITOH Masatsune Kanazawa Medical University, 医学部, 講師 (60367472)
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| Co-Investigator(Kenkyū-buntansha) |
SATO Hitoshi 金沢医科大学, 医学部, 助教 (20303224)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 甲状腺ホルモン輸送体(MCT8) / 胎児脳発達 / 甲状腺ホルモン / 乳酸 / ピルビン酸 |
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| Research Abstract |
We studied the effect of thyroid hormone in fetal brain. Thyroid hormone transporter (MCT8) was cloned and plasmid was created based on cloning MCT8. For a normal fetal brain development, it was suggested that thyroid hormone is necessary equivalent amount of wild-type. MCT8 deficiency showed high levels of serum lactic acid in early infancy, it was suggested to be useful as a diagnostic marker. To confirm the localization of MCT8 protein in the brain, we immunized the rabbit with a synthetic peptide derived from human MCT8 and an antibody was purified from rabbit serum.
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