• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2008 Fiscal Year Final Research Report

Studies on the mechanisms of activation and inactivation of factor VIII : applications of novel coagulant and anticoagulant therapy

Research Project

  • PDF
Project/Area Number 19591264
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatrics
Research InstitutionNara Medical University

Principal Investigator

NOGAMI Keiji  Nara Medical University, 医学部, 助教 (50326328)

Project Period (FY) 2007 – 2008
Keywords血液凝固 / 第VIII因子 / 外因系 / 線溶系 / 凝固抑制系 / 酵素 / 相互作用
Research Abstract

血液凝固内因系第VIII因子(FVII)は、欠乏では重篤出血(血友病A)を、逆に増加は血栓形成を惹起する。従来凝固研究は、内因系/外因系/凝固抑制系/線溶系に分けて研究されてきたが、実際の凝固過程は複数系が互いに絡み合い進行していくと支持されつつある。本研究で、凝固反応で最も鍵を握るFVIIが、内因系のみならず、線溶系因子(プラスミン)、凝固抑制因子(プロテインS)、外因系因子(FVII)と相互作用することで凝固血栓が巧みに制御されていることがわかった。

  • Research Products

    (17 results)

All 2009 2008 2007

All Journal Article (9 results) Presentation (8 results)

  • [Journal Article] Identification of plasmin-interactive sites in the light chain of factor VIII responsible for proteolytic cleavage at Lys362009

    • Author(s)
      Nogami K, Nishiya K, et.al.(他5名)
    • Journal Title

      J Biol Chem 284

      Pages: 6934-45

  • [Journal Article] The factor VIIIa C2 domain (residues 2228-2240) interacts with the factor IXa Gla domain in the factor Xase complex2009

    • Author(s)
      Soeda T, Nogami K, et.al.(他6名)
    • Journal Title

      J Biol Chem 284

      Pages: 3379-88

  • [Journal Article] Identification of a plasmin-interactive site within the A2 domain of the factor VIII heavy chain2008

    • Author(s)
      Nogami K, Shima M, et.al.(他5名)
    • Journal Title

      Biochim Biophys Acta 1784

      Pages: 753-63

  • [Journal Article] Protein S down-regulates factor Xase activity independent of activated protein C : specific binding of factor VIII(a) to protein S inhibits interactions with factor IXa2008

    • Author(s)
      Takeyama M, Nogami K, et.al.(他5名)
    • Journal Title

      Br J Haematol 143

      Pages: 409-20

  • [Journal Article] Selective factor VIII and V inactivation by iminodiacetate ion exchange resin through metal ion adsorption2008

    • Author(s)
      Takeyama M, Nogami K, et.al.(他5名)
    • Journal Title

      Br J Haematol 142

      Pages: 962-70

  • [Journal Article] Identification of a thrombin-interactive site within the FVIII A2 domain that is responsible for the cleavage at Arg3722008

    • Author(s)
      Nogami K, Saenko EL, et.al.(他4名)
    • Journal Title

      Br J Haematol 140

      Pages: 433-43

  • [Journal Article] Relationship between the binding sites for von Willebrand factor, phospholipid, and human factor VIII C2 inhibitor alloantibodies within the factor VIII C2 domain2007

    • Author(s)
      Nogami K, Shima M et.al.(他4名)
    • Journal Title

      Int J Hematol 85

      Pages: 317-22

  • [Journal Article] Mechanisms of plasmin-catalyzed inactivation of factor VIII2007

    • Author(s)
      Nogami K, Shima M, et.al.(他4名)
    • Journal Title

      J Biol Chem 282

      Pages: 5287-95

  • [Journal Article] 血友病Aの分子病態. 第VIII因子の分子構造および機能の最近の知見2007

    • Author(s)
      野上恵嗣
    • Journal Title

      血栓止血誌 19

      Pages: 779-87

  • [Presentation] Tissue factor-dependent activation of factor VIII by factor VIIa in the early phase of bloodcoagulation2008

    • Author(s)
      Soeda T, Nogami K, et.al.
    • Organizer
      50^<th> Annual meeting of American Society of Hematology
    • Place of Presentation
      San Francisco, CA
    • Year and Date
      2008-12-06
  • [Presentation] Identification of a factor IXa-interactive site within the C2 domain of factor VIIIa and a crucial role of these associations for the process of clot formation2008

    • Author(s)
      Soeda T, Nogami K, et.al.
    • Organizer
      50^<th> Annual meeting of American Society of Hematology
    • Place of Presentation
      San Francisco, CA
    • Year and Date
      2008-12-06
  • [Presentation] 「血友病の分子病態の進歩と臨床応用の展望」 FVIIa、FVIIIを介する止血メカニズムの新たな展開2008

    • Author(s)
      荻原建一、野上恵嗣、他
    • Organizer
      第31回日本血栓止血学会学術集会
    • Place of Presentation
      大阪市
    • Year and Date
      2008-11-20
  • [Presentation] 6-aminohexanoic acid(6-AHA)の凝固亢進作用2008

    • Author(s)
      荻原建一、野上恵嗣、他
    • Organizer
      第31回日本血栓止血学会学術集会
    • Place of Presentation
      大阪市
    • Year and Date
      2008-11-20
  • [Presentation] Localization of factor VIII-interactive site within plasmin/plasminogen which is responsible for plasmin-catalyzed activation and inactivation of factor VIII2007

    • Author(s)
      Nishiya K, Nogami K, et.al.
    • Organizer
      49^<th> Annual meeting of American Society of Hematology
    • Place of Presentation
      Atlanta, GA
    • Year and Date
      2007-12-09
  • [Presentation] Identification of protein S-interactive site on the factor VIII A2 domain2007

    • Author(s)
      Takeyama M, Nogami K, et.al.
    • Organizer
      49^<th> Annual meeting of American Society of Hematology
    • Place of Presentation
      Atlanta, GA
    • Year and Date
      2007-12-09
  • [Presentation] 凝固初期相におけるプラスミンの向凝固作用2007

    • Author(s)
      荻原建一、野上恵嗣他
    • Organizer
      第30回日本血栓止血学会学術集会
    • Place of Presentation
      三重県賢島市
    • Year and Date
      2007-11-17
  • [Presentation] 血友病Aインヒビターの免疫生化学的側面2007

    • Author(s)
      野上恵嗣
    • Organizer
      第30回日本血栓止血学会学術集会
    • Place of Presentation
      三重県賢島市
    • Year and Date
      2007-11-15

URL: 

Published: 2010-06-10   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi