2008 Fiscal Year Final Research Report
Epigenetic mechanism underlying olfactory learning in young animal
| Project/Area Number |
19591282
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Embryonic/Neonatal medicine
|
|---|
| Research Institution | Kochi University |
|---|
Principal Investigator |
OKUTANI Fumino Kochi University, 教育研究部医療学系, 准教授 (10194490)
|
|---|
| Project Period (FY) |
2007 – 2008
|
| Keywords | 新生児医学 / 記憶・学習 / 幼若ラット / 嗅覚 / ヒストン / 脱アセチル化 |
|---|
| Research Abstract |
Preweanling young rats prior to eye opening depend on somatosensory and olfactory function for survival, as they can learn their dam's odor and approach her without visual information. In order to establish olfactory learning, the pairing of odor and somatosensory stimulation is crucial. We have previously shown that synaptic plasticity in the OB underlies aversive olfactory learning. Particularly as cellular mechanisms, chromatin structure is remodeled by modification of histone acetylation during the early stages of long-term memory formation. Behavioral pharmacology shows that HDAC inhibition consolidates aversive olfactory learning in young rats.
|
Research Products
(17 results)
-
-
-
[Journal Article] Effects of olfactory stimulation with isovaleric acid on brain activation in informed and naive conditions: A functional MRT study.2007
Author(s)
Murata, Y. Okutani, F. Nakahira, M. Ushida, T. Ikemoto, T. Yokoe, I. Takeda, T. Kaba, H. Tani, T., Ogawa, Y.
-
Journal Title
Auri s Nasus Larynx 34
Pages: 465-469
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
