Studies on possible roles of midkine, a heparin -binding growth factor, in the human feto -amniotic unit

2008 Fiscal Year Final Research Report

• Project/Area Number: 19591288
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Embryonic/Neonatal medicine
• Research Institution: Tokai University (2008); Keio University (2007)
• Principal Investigator: ISHIMOTO Hitoshi Tokai University, 医学部, 教授 (10212937)
• Co-Investigator(Kenkyū-buntansha): HIGUCHI Takayuki 慶應義塾大学, 医学部, 助教 (30365332) ; ASAI Satoshi 慶應義塾大学, 医学部, 助教 (70383867)
• Research Collaborator: JAFFE Robert B. カリフォルニア大学サンフランシスコ校, 医学部, 教授
• Project Period (FY): 2007 – 2008
• Keywords: ミッドカイン / 羊膜 / 胎児 / 副腎 / 羊水

Research Abstract

本研究により、ヘパリン結合性成長因子であるミッドカイン(MK)が羊膜に作用する「胎児シグナル」として働き、子宮収縮物質であるプロスタグランディンを産生する酵素であるCOX2の発現抑制などを介して妊娠維持に関与している可能性が示唆された。またMKはACTH受容体の発現を抑制し、ヒト胎児副腎の恒常性維持に関与している可能性があることが示唆された。従来の研究成績とあわせ、MKは分娩発来機構の中にあって抑制制御因子、あるいは恒常性維持因子として働いている可能性が推察された。

Research Products

• [Journal Article] Prenatal diagnosis of retroperitoneal teratoma : a case report and review of literature (2009)
  • Author(s): Asai S, Ishimoto H, KimS H, Higuchi T, Minegishi K, Tanaka M, Hoshino K, Morikawa Y, Yoshimura Y.
  • Journal Title: Fetal Diagn Ther 25 Pages: 76-78
  • Peer Reviewed
• [Journal Article] The periphery of the human fetal adrenal gland is a site of angiogenesis : zonal differential expression and regulation of angiogenic factors (2008)
  • Author(s): Ishimoto H, Minegishi K, Higuchi T, Furuya M, Asai S, Kim SH, Tanaka M, Yoshimura Y, Jaffe RB.
  • Journal Title: J Clin Endocrinol Metab 93 Pages: 2402-2408
  • Peer Reviewed
• [Presentation] Regulation of Expression of Angiotensin II Receptor Subtypes and ACTH Receptor by ACTH and Angiotensin II in Human Fetal Adrenal Cells (2008)
  • Author(s): Ishimoto H, Minegishi K, Higuchi T, Asai S, Kim SH, Tanaka M, Yoshimura Y, Jaffe RB
  • Organizer: 90th Annual Meeting of the Endocrine Society
  • Place of Presentation: San Francisco, USA
  • Year and Date: 2008-06-17
• [Presentation] ヘパリン結合性成長因子Midkine のヒト胎児羊膜系における発現についての検討 (2008)
  • Author(s): 樋口隆幸, 石本人士, 金善惠, 浅井哲, 峰岸一宏, 田中守, 青木大輔, 吉村泰典
  • Organizer: 第60回日本産科婦人科学会学術講演会
  • Place of Presentation: 横浜(パシフィコ横浜)
  • Year and Date: 2008-04-15
• [Presentation] Profile of Midkine, a Heparin-Binding Growth Factor, in Human Amniotic Fluid and Amnion (2008)
  • Author(s): Ishimoto H, Higuchi T, Minegishi K, Asai S, Kim SH, Tanaka M, Jaffe RB, Yoshimura Y.
  • Organizer: 55th Annual Meeting of the Society for Gynecologic Investigation
  • Place of Presentation: San Diego, USA
  • Year and Date: 2008-03-27
• [Presentation] Expression profile of a heparin-binding growth factor, midkine, in human fetal tissues and the placenta (2007)
  • Author(s): Higuchi T, Ishimoto H, Asai S, Minegishi K, Tanaka M, Yoshimura Y, Jaffe RB.
  • Organizer: 89th Annual Meeting of the Endocrine Society
  • Place of Presentation: Toronto, Canada..
  • Year and Date: 2007-06-04
• [Presentation] Down-regulation of ACTH receptor gene expression by an ACTH-inducible heparin-binding growth factor, midkine in human fetal adrenal cells (2007)
  • Author(s): Ishimoto H, Higuchi T, Asai S, Minegishi K, Tanaka M, Yoshimura Y, Jaffe RB
  • Organizer: 89th Annual Meeting of the Endocrine Society
  • Place of Presentation: Toronto, Canada
  • Year and Date: 2007-06-04