2009 Fiscal Year Final Research Report
Analyses of reduced brain injury by treatment with neural stem /progenitor cells together with chondroitinase.
| Project/Area Number |
19591290
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Institute for Developmental Research, Aichi Human Service Center |
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Principal Investigator |
NAKANISHI Keiko Institute for Developmental Research, Aichi Human Service Center, 周生期学部, 主任研究員 (50280813)
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| Research Collaborator |
大平 敦彦 愛知医科大学, 先端医学医療研究拠点, 客員教授
佐藤 義朗 名古屋大学, 周産母子センター, 病院助教
山田 恭聖 愛知県心身障害者コロニー中央病院, 新生児科, 医長
伊藤 美春 愛知県心身障害者コロニー中央病院, 新生児科, 医師
青野 幸子 愛知県心身障害者コロニー発達障害研究所, 周生期学部, 主任研究員
時田 義人 愛知県心身障害者コロニー発達障害研究所, 周生期学部, 主任研究員
松井 ふみ子 愛知県心身障害者コロニー発達障害研究所, 研究員
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| Project Period (FY) |
2007 – 2009
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| Keywords | 新生児低酸素性虚血性脳症 / 神経幹細胞 / oxygen-glucose depletion |
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| Research Abstract |
Administration of neural stem/progenitor cells (NSPCs) with chondroitinase (CHase) reduced brain injury in a neonatal hypoxic-ischemic rat model. To investigate its mechanism, we established in vitro hypoxic-ischemic model. GFP-transgenic rat neurons were cultured and exposed to oxygen-glucose depletion (OGD). Treatment with NSPCs combined with CHase was tended to reduce OGD-induced neuronal cell death. We are currently trying to find the factors regulating neuroprotection using this model.
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[Journal Article] Reduction of brain injury in neonatal hypoxic-ischemic rats by intracerebroventricular injection of neural stem/progenitor cells together with chondroitinase ABC2008
Author(s)
Sato Y, Nakanishi K, Hayakawa M, Kakizawa H, Saito A, Kuroda Y, Ida M, Tokita Y, Aono S, Matsui F, Kojima S, Oohira A
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Journal Title
Reproductive Science 15
Pages: 813-820
Peer Reviewed
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[Journal Article] A highly sulfated chondroitin sulfate preparation, CS-E, prevents excitatory amino acid-induced neuronal cell death2008
Author(s)
Sato Y, Nakanishi K, Tokita Y, Kakizawa H, Ida M, Maeda H, Matsui F, Aono S, Saito A, Kuroda Y, Hayakawa M, Kojima S, Oohira A
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Journal Title
J Neurochem 104
Pages: 1565-1576
Peer Reviewed
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[Journal Article] Ectodomain shedding of neuroglycan C, a brain-specific chondroitin sulfate proteoglycan, by TIMP-2-and TIMP-3-sensitive proteolysis2007
Author(s)
Shuo T, Aono S, Nakanishi K, Tokita Y, Kuroda Y, Ida M, Matsui F, Maruyama H, Kaji T, Oohira A
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Journal Title
J Neurochem 102
Pages: 1561-1568
Peer Reviewed
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[Journal Article] Neuroprotective effect of nipradilol, an NO donor, on hypoxic-ischemic brain injury of neonatal rats2007
Author(s)
Kakizawa H, Matsui F, Tokita Y, Hirano K, Ida M, Nakanishi K, Watanabe M, Sato Y, Okumura A, Kojima S, Oohira A
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Journal Title
Early Human Development 83
Pages: 535-540
Peer Reviewed
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