2010 Fiscal Year Final Research Report
Pathological mechanisms of keratinization abnormalities
| Project/Area Number |
19591294
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Dermatology
|
|---|
| Research Institution | Asahikawa Medical College |
|---|
Principal Investigator |
YAMAMOTO Akemi Asahikawa Medical College, 医学部, 准教授 (30241441)
|
|---|
| Project Period (FY) |
2007 – 2010
|
| Keywords | 皮膚病理学 / 角化細胞 |
|---|
| Research Abstract |
We have studied mechanisms of normal keratinization and abnormal keratinization. We have found evidences to suggest that tight junctions are involved in spatially distinct degradation of corneodesmosomes and in lamellar granule transportation and secretion. We have revealed that abnormal transportation and/or secretion of lamellar granules could result in ichthyosis in two genetic diseases, CEDNIK syndrome and ARC syndrome. We found that corneodesmosin in crucial for corneocyte adhesion. We have found evidences to suggest that Rab11 may be involved in lamellar granule transportation.
|
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] 角化異常症2010
Author(s)
山本明美
Organizer
第109回日本皮膚科学会総会
Place of Presentation
大阪国際会議場、大阪府
Year and Date
20100416-20100417
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
