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2008 Fiscal Year Final Research Report

Regulation of chemokine production in human epidermal keratinocyte by IL-17 stimulation

Research Project

  • PDF
Project/Area Number 19591313
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Dermatology
Research InstitutionEhime University

Principal Investigator

TOYAMA Mikiko  Ehime University, 医学部・附属病院, 助教 (60263935)

Project Period (FY) 2007 – 2008
Keywords皮膚生理学 / サイトカイン
Research Abstract

皮膚の慢性炎症性疾患として、アトピー性皮膚炎、乾癬がよく知られており、どちらの疾患の病変部位にもIL-17 を産生するリンパ球が存在している。炎症の誘導には、表皮角化細胞より産生されるケモカインが重要な役割を果たしているが、疾患によりその発現パターンは異なっている。ケモカインの産生は炎症性サイトカインで誘導されるが、IL-17 の存在が、その産生を制御していることを明らかにした。

  • Research Products

    (5 results)

All 2008 2007

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (2 results)

  • [Journal Article] A marked increase in serum soluble Fas ligand in drug-induced hypersensitivity syndrome2008

    • Author(s)
      Tohyama M, et.al.
    • Journal Title

      Br J Dermatol 159

      Pages: 981-984

    • Peer Reviewed
  • [Journal Article] CXCL16 is a novel mediator of the innate immunity of epidermal keratinocytes2008

    • Author(s)
      Tohyama M, et.al.
    • Journal Title

      Int Immunol 19

      Pages: 1095-1102

    • Peer Reviewed
  • [Journal Article] Association of human herpesvirus 6 reactivation with the flaring and severity of drug-induced hypersensitivity syndrome2007

    • Author(s)
      Tohyama M, et.al.
    • Journal Title

      Br J Dermatol 157

      Pages: 934-940

    • Peer Reviewed
  • [Presentation] Augmentation of IL-22 receptor expression and IL-20 subfamily production plays a critical role in psoriasis2008

    • Author(s)
      Tohyama M.
    • Organizer
      a International Investigative Dermatology 2008
    • Place of Presentation
      京都
    • Year and Date
      2008-05-17
  • [Presentation] Novel mechanism of Stevens-Johnson syndrome and TEN : involvement of fractalkine and CD16+ mononuclear cells.2007

    • Author(s)
      Tohyama M.
    • Organizer
      第32回研究皮膚科学会
    • Place of Presentation
      横浜
    • Year and Date
      2007-04-20

URL: 

Published: 2010-06-10   Modified: 2016-04-21  

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