A study of neural circuits underlying stress regulation at the critical period during brain development

2008 Fiscal Year Final Research Report

• Project/Area Number: 19591335
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Health Sciences University of Hokkaido
• Principal Investigator: MATSUMOTO Machiko Health Sciences University of Hokkaido, 薬学部, 准教授 (70229574)
• Co-Investigator(Kenkyū-buntansha): YOSHIOKA Itsuhiro 北海道大学, 医学部, 教授 (40182729) ; YAMAGUCH Taku 北海道大学, 医学部, 助教 (80325563) ; IZUMI Takeshi 北海道大学, 医学部, 助教 (60312360)
• Project Period (FY): 2007 – 2008
• Keywords: 脳発達 / ストレス / 臨界期

Research Abstract

本研究は、幼児虐待を視野に入れ、脳内神経回路網が急速に発達する幼児期に過度のストレスを負荷すると、成長後ストレスに対する脆弱性が生じるとの仮説を動物実験により証明した。すなわちラット幼若期の一定期間にストレスを負荷により、成長後の情動行動ならびにシナプス応答に異常が生じることを明らかにし、またその背景にはセロトニン神経の機能変化による可能性を示唆した。

Research Products

• [Journal Article] Togashi H: Possible relationship between the stress-induced synaptic response and metaplasticity in the hippocampal CA1 field of freely moving rats (2009)
  • Author(s): Hirata R, Matsumoto M, Judo, C, Yamaguchi T, Izumi T, Yoshioka M
  • Journal Title: Synapse 63 Pages: 549-556
  • Peer Reviewed
• [Journal Article] Characterization of stress-induced suppression of long-term potentiation in the hippocampal CA1 field of freely moving rats (2008)
  • Author(s): Hirata,R Togashi H, Matsumoto M, Yamaguchi T, Izumi T, Yoshioka M:
  • Journal Title: Brain Reseach 1226 Pages: 27-32
  • Peer Reviewed
• [Journal Article] Characterization of clozapine-induced changes in synaptic plasticity in the hippocampal-mPFC pathway of anesthetized rats (2008)
  • Author(s): Matsumoto M, Shikanai H, Togashi H, Izumi T, Kitta T, Hirata R, Yamaguchi T, Yoshioka M
  • Journal Title: Brain Research 1195 Pages: 50-55
  • Peer Reviewed
• [Journal Article] Early postnatal stress alters the extinction of context-dependent conditioned fear in adult rats (2008)
  • Author(s): Matsumoto M, Togashi H, Konnno K, Koseki H, Hirata R, Izumi T, Yamaguchi T, Yoshioka M
  • Journal Title: Pharmacology, Biochemistry and Behavior 89 Pages: 247-252
  • Peer Reviewed
• [Journal Article] Effects of aversive stress during brain development on hippocampal synaptic and behavioral responses to emotional stress at postadolescence (2007)
  • Author(s): Koseki H, Matsumoto M, Togashi H, Yamaguchi T, Izumi T, Yoshioka M
  • Journal Title: Nihon Shinkei Seishin Yakurigaku Zasshi 27 Pages: 19-27
  • Peer Reviewed
• [Journal Article] Early postnatal stress affects the serotonergic function in the median raphe nuclei of adult rats (2007)
  • Author(s): Konno K, Matsumoto M, Togashi H, Yamaguchi T, Izumi T, Watanabe M, Iwanaga T, Yoshioka M
  • Journal Title: Brain Research 1172 Pages: 60-66
  • Peer Reviewed
• [Journal Article] Alteration of synaptic transmission in the hippocampal-mPFC pathway during extinction trials of context-dependent fear memory in juvenile rat stress models
  • Author(s): Koseki H., Matsumoto M., Togashi H., Miura Y., Fukushima K., Yoshioka M
  • Journal Title: Synapse in press
  • Peer Reviewed
• [Journal Article] Early Postnatal stress and neural circuits underlying emotional regulation
  • Author(s): Matsumoto M., Yoshioka M., Togashi H
  • Journal Title: International Review of Neurobiology in press
  • Peer Reviewed
• [Presentation] Stress-induced synaptic response and metaplasticity in the hippocampal (2008)
  • Author(s): 松本真知子, 他
  • Organizer: CA1 field of freely moving rats
  • Place of Presentation: Geneva, Switzedland
  • Year and Date: 20080712-16
• [Presentation] ラット海馬シナプスの可塑的変化と皮質前頭前野による調節 (2008)
  • Author(s): 松本真知子, 他
  • Organizer: 第128回日本薬学会年会
  • Place of Presentation: 横浜
  • Year and Date: 20080326-28
• [Presentation] ラット幼若期のストレス負荷は成長後の情動ストレスに対する (2007)
  • Author(s): 松本真知子, 他
  • Organizer: 第30回日本神経科学会
  • Place of Presentation: 横浜
  • Year and Date: 20070910-12
• [Presentation] Characterization of clozapine-induced synaptic changes in the hippocampo-mPFC pthway of anesthetized rats (2007)
  • Author(s): 松本真知子, 他
  • Organizer: Dopamine 50 year
  • Place of Presentation: Goeteborg, Sweden
  • Year and Date: 20070530-0602