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2008 Fiscal Year Final Research Report

CSF Histamine levels in patients with hypersomnia, and hypothalamic peptides in recurrent hypersomnia

Research Project

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Project/Area Number 19591337
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionAkita University

Principal Investigator

SHIMIZU Tetsuo  Akita University, 医学部, 教授 (90170977)

Project Period (FY) 2007 – 2008
Keywords過眠症 / オレキシン / ヒスタミン / Kleine-Levin syndrome / 反復性過眠症 / αMSH / AGRP
Research Abstract

髄液ヒスタミン値が過眠症状に依存性に低値であることが明らかになった。コントロ-ルに比べて、HLA-DR2陽性で脱力発作のあるオレキシンが低値のナルコレプシ-だけではなく、オレキシン値は正常である特発性過眠症、DR2 陰性や脱力発作のないナルコレプシ-でもヒスタミン値は有意に低値であった。しかしながら、リタリン等の中枢神経刺激薬を内服している症例では、対照群との有意差は認められなかった。ナルコレプシ-ではリタリンの内服の有無にて、オレキシン値に変化はないが、ヒスタミン値に関しては、高値になる傾向がみられた。ヒスタミン値は、睡眠時無呼吸症では対照群と同等な値であった。

  • Research Products

    (8 results)

All 2009 2008

All Journal Article (5 results) (of which Peer Reviewed: 4 results) Presentation (2 results) Book (1 results)

  • [Journal Article] CSF histamine contents in narcolepsy, idiopathic hypersomnia and obstructive sleep apnea syndrome2009

    • Author(s)
      Kanbayashi T, Kodama T, Kondo H, Satoh S, Inoue Y, Chiba S, Shimizu T, Nishino S.
    • Journal Title

      Sleep 32(2)

      Pages: 181-7

    • Peer Reviewed
  • [Journal Article] Symptomatic Narcolepsy in Neuromyelitis Optica and Multiple Sclerosis Patients ; New Neurochemical and Immunological Implications2009

    • Author(s)
      Kanbayashi T, Shimohata T, Nakashima I, Shimizu T, Nishino S.
    • Journal Title

      Arch Neurol. 66(in press)

    • Peer Reviewed
  • [Journal Article] Cerebrospinal fluid-orexin levels and sleep attacks in four patients with Parkinson's disease2009

    • Author(s)
      Asai H, Hirano M, Furiya Y, Udaka F, Kanbayashi T, Shimizu T, Ueno S.
    • Journal Title

      Clin Neurol Neurosurg 111(4)

      Pages: 341-4

    • Peer Reviewed
  • [Journal Article] Narcolepsy as an initial manifestation of neuromyelitis optica with anti-aquaporin-4 antibody2009

    • Author(s)
      Baba T, Nakashima I, Kanbayashi T, Konno M, Takahashi T, Fujihara K, Misu T, Takeda A, Shiga Y, Ogawa H, Itoyama Y.
    • Journal Title

      J Neurol. 256(2)

      Pages: 287-8

    • Peer Reviewed
  • [Journal Article] 視床下部病変によりオレキシン神経障害を来して生じた2次性の過眠症2008

    • Author(s)
      神林崇、清水徹男, 等
    • Journal Title

      睡眠医療 2

      Pages: 157-164

  • [Presentation] CSF HYPOCRETIN-1 (OREXIN-A) MEASUREMENT IN PEDIATRIC AND TEENAGE PATIENTS WITH SLEEP DISORDERS2009

    • Author(s)
      Arii J, Kanbayashi T, Shimizu T
    • Organizer
      22nd Annual Meeting of the Associated Professional Sleep Societies
    • Place of Presentation
      Baltimore, Maryland, USA
    • Year and Date
      2009-06-10
  • [Presentation] AVERAGE HYPOCRETIN AND ELEVATED AGRP IN THE CSF OF PATIENTS WITH ANOREXIA NERVOSA SLEEP2008

    • Author(s)
      Maruyama F, Kanbayashi T, Satoh S, Okuda M, Aizawa R, Ogawa-Hayashi Y, Ishikawa H, Takemura F, Sagawa Y, Shimizu T.
    • Organizer
      Volume 31, Abstract Supplement
    • Place of Presentation
      (A215-16)
    • Year and Date
      20080000
  • [Book] NARCOLEPSY(in press)2009

    • Author(s)
      Kanbayashi T, Shimizu T
    • Publisher
      Nishino Humana/Springer

URL: 

Published: 2010-06-10   Modified: 2016-04-21  

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