Genome-wide association study of panic disorder

2008 Fiscal Year Final Research Report

• Project/Area Number: 19591340
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: The University of Tokyo
• Principal Investigator: UMEKAGE Tadashi The University of Tokyo, 環境安全本部, 准教授 (20323587)
• Co-Investigator(Kenkyū-buntansha): SASAKI Tsukasa 東京大学, 学生支援ネットワーク本部, 教授 (50235256)
• Co-Investigator(Renkei-kenkyūsha): SASAKI Tsukasa 東京大学, 学生支援ネットワーク本部, 教授 (50235256)
• Project Period (FY): 2007 – 2008
• Keywords: パニック障害 / 遺伝子 / ゲノムワイド関連研究

Research Abstract

本研究は、パニック障害患者を対象にゲノムワイド関連解析(Genome-wide associationstudy)を行なうものである。東京大学精神神経科を中心とする当グループは、すでに日本人患者のサンプルを1100例(世界最大規模)収集した。その中の患者200例(と健康対照者200例)について、Affymetric社の500K SNPチップを使用し全ゲノム解析を行った結果、アリル頻度の患者-対照比較で有意差(P<0.0001)を示す50個のSNPsが見出された。現在さらに800例について全ゲノム解析を進めている.

Research Products

• [Journal Article] Noassociation between the brain-derivedneurotrophic factor (BDNF) gene and panicdisorder in Japanese population (2009)
  • Author(s): Otowa T, Shimada T, Kawamura Y, Liu X,Inoue K, Sugaya N, Minato T, Nakagami R, Tochigi M, Umekage T, Kasai K, Kato N, Tanii H, Okazaki Y, Kaiya H, Sasaki T.
  • Journal Title: J Hum Genet (in press)
  • Peer Reviewed
• [Journal Article] Okazaki YGenome-wide association study of panic disorder in theJapanese population (2009)
  • Author(s): Otowa T, Yoshida E, Sugaya N, Yasuda S, Nishimura Y, Inoue K, Tochigi M, UmekageT, Miyagawa T, Nishida N, Tokunaga K, TaniiH, Sasaki T, Kaiya H.
  • Journal Title: J Hum Genet 54(2) Pages: 122-6
  • Peer Reviewed
• [Journal Article] Appropriate data cleaning methods forgenome-wide association study (2008)
  • Author(s): Miyagawa T, Nishida N, Ohashi J, Kimura R, Fujimoto A, Kawashima M, Koike A, SasakiT, Tanii H, Otowa T, Momose Y, Nakahara Y, Gotoh J, Okazaki Y, Tsuji S, Tokunaga K.
  • Journal Title: J Hum Genet 53(10) Pages: 886-93
  • Peer Reviewed
• [Journal Article] Birth months and vulnerability to juveniledelinquency (2008)
  • Author(s): Ohtani T, Sasaki T, Kadomoto I, Kato N, Yoshinaga C.
  • Journal Title: Prog Neuropsycopharmacol Biol Psychiatry 32 Pages: 49-53
  • Peer Reviewed
• [Journal Article] Association study of monoamine oxidase and catechol-O-methyltransferase genes withsmoking behavior (2007)
  • Author(s): Tochigi M, Suzuki K, Kato C, Otowa T, Hibino H, Umekage T, Kato N, Sasaki T.
  • Journal Title: Pharmacogenet Genomics 17(10) Pages: 867-72
  • Peer Reviewed
• [Presentation] The Relationship between Cognitive Factors and Agoraphobia in PanicDisorder Patients with Irritable Bowel Syndrome (2009)
  • Author(s): N Sugaya, E Yoshida, S Yasuda, A109MTochigi, K Takei, T Otani, T Otowa, TMinato, T Umekage, Y Sakano, J Chen, SNomura, H Shimada, H Tanii, T Sasaki, YOkazaki, H Kaiya
  • Organizer: 20th World Congress on PSYCHOSOMATIC MEDICINE
  • Place of Presentation: Torino Italy
  • Year and Date: 2009-09-24
• [Presentation] Changes in Changes of cerebral blood volumeduring a verbal fluency task in patientswith social anxiety disorder : Amulti-channel near-infrared spectroscopystudy (2009)
  • Author(s): C Yokoyama, H Kaiyal, Y Nishimura, H Tanii, M Kinou1, T Otowa, T Umekage, S Yasuda, KTakei, Y Kaneko, S Suzuki, T Sasaki, Yokazaki
  • Organizer: 第1回日本不安障害学会
  • Place of Presentation: 東京
  • Year and Date: 2009-03-28
• [Presentation] 不安障害の生物学-遺伝的研究の立場から (2009)
  • Author(s): 音羽健司, 佐々木司
  • Organizer: 第1回日本不安障害学会
  • Place of Presentation: 東京
  • Year and Date: 2009-03-28
• [Presentation] クモ恐怖症に対するエクスポージャー法のNIRS による効果検証 (2007)
  • Author(s): 長谷川誠、福井 至、Douglas Eames、久保田俊一郎、梅景 正、宇佐美英里、吉田栄治、貝谷久宣
  • Organizer: 第33回日本行動療法学会
  • Place of Presentation: 神戸
  • Year and Date: 2007-11-30
• [Presentation] Phsophodiesterase 4B (PDE4B) is potentialrisk locus of panic disorder : evidencefrom genome-wide association study (2007)
  • Author(s): T Otowa, M Tochigi, T Umekage, N Sugaya, KInoue, E Yoshida, H Tanii, Y Okazaki, HKaiya, K Tokunaga, T Sasaki
  • Organizer: World Congress on Psychiatric Genetics XV
  • Place of Presentation: New York
  • Year and Date: 2007-10-10
• [Book] パニック障害の全ゲノム関連研究 (2009)
  • Author(s): 音羽健司, 佐々木司
  • Total Pages: 191-194
  • Publisher: 医歯薬出版
• [Book] 入院の診立て・判断-パニック障害の場合 (2009)
  • Author(s): 貝谷久宣、吉田栄治、土田英人、梅景 正
  • Total Pages: 437-442
  • Publisher: 星和書店
• [Book] 疲労とパニック障害 (2008)
  • Author(s): 貝谷久宣、岩佐玲子、梅景 正、栃木 衛、山中 学、土田英人
  • Total Pages: 579-585
  • Publisher: 医学書院
• [Book] パニック障害の遺伝子心療内科 (2008)
  • Author(s): 音羽健司、佐々木司
  • Total Pages: 12(1) : 5-10
  • Publisher: 科学評論社
• [Book] パニック障害 (2007)
  • Author(s): 貝谷久宣、井上 顕、横山知加、土田英人、山中 学、梅景 正、栃木 衛
  • Total Pages: 541-544
  • Publisher: Journal of Otolaryngology, Head and Surgery