• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2009 Fiscal Year Self-evaluation Report

Development of new tools for the diagnosis of prodromal stage of schizophrenia and early treatment methods

Research Project

  • PDF
Project/Area Number 19591345
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionUniversity of Toyama

Principal Investigator

SUMIYOSHI Tomiki  University of Toyama, 大学院・医学薬学研究部(医学), 准教授 (80286062)

Project Period (FY) 2007 – 2010
Keywords統合失調症 / 早期介入 / 薬物療法 / 認知機能 / 脳画像
Research Abstract

(1)統合失調症(警告期)の新しい客観的・生物学的診断法を開発する。方法として、短時間で施行可能な神経心理検査で測定できる認知機能障害のパターンや、事象関連電位(ERP)による脳機能画像所見など、相互関係を含め多角的に検討し、日常診療に応用可能な診断指標の探索を行う。
(2)統合失調症(警告期)にある患者への介入を目指した薬物治療法を探求する。特にセロトニン受容体に作用する薬物などの投与が、認知機能の障害や社会的予後を改善するか解明する。

  • Research Products

    (18 results)

All 2009 2008 2007

All Journal Article (11 results) (of which Peer Reviewed: 11 results) Presentation (5 results) Book (2 results)

  • [Journal Article] Semantic memory deficits based on category fluency performance in schizophrenia : Similar impairments across Turkish and Japanese patients2009

    • Author(s)
      Sumiyoshi C., Ertugrul A., Anil Yagcioglu A. E., Sumiyoshi T.
    • Journal Title

      Psychiatry Res 167

      Pages: 47-57

    • Peer Reviewed
  • [Journal Article] Long-term effects of neonatal MK-801 treatment on prepulse inhibition in young adult rats2009

    • Author(s)
      Uehara, T., Sumiyoshi, T., et al.
    • Journal Title

      Psychopharmacology (Berl) 206

      Pages: 623-30

    • Peer Reviewed
  • [Journal Article] Effect of perospirone on P300 electrophysiological activity and social cognition in schizophrenia : A three-dimensional analysis with sLORETA2009

    • Author(s)
      Sumiyoshi T., et al.
    • Journal Title

      Psychiatry Res Neuroimag 17

      Pages: 180-3

    • Peer Reviewed
  • [Journal Article] Does stimulation of 5-HT_<1A> receptors improve cognition in schizophrenia?2008

    • Author(s)
      Meltzer H. Y., Sumiyoshi T.
    • Journal Title

      Behav Brain Res 195

      Pages: 98-102

    • Peer Reviewed
  • [Journal Article] Calcineurin Aγ and B gene expressions in the whole blood in Japanese patients with schizophrenia2008

    • Author(s)
      Murata M., Tsunoda M., Sumiyoshi T., et al.
    • Journal Title

      Prog Neuro-Psychopharmacol & Biol Psychiatry 32

      Pages: 1000-4

    • Peer Reviewed
  • [Journal Article] Electrophysiological basis for the ability of olanzapine to improve verbal memory and functional outcome in patients with schizophrenia : A LORETA analysis of P3002008

    • Author(s)
      Higuchi Y., Sumiyoshi T., et al
    • Journal Title

      Schizophr Res 101

      Pages: 320-30

    • Peer Reviewed
  • [Journal Article] T-817 a novel neurotrophic compound, ameliorates phencyclidine-induced disruption of sensorimotor gating2008

    • Author(s)
      Seo T., Sumiyoshi T., et al
    • Journal Title

      Psychopharmacology 197

      Pages: 457-64

    • Peer Reviewed
  • [Journal Article] Cognitive functioning related to quality of life in schizophrenia2008

    • Author(s)
      Matsui M., Sumiyoshi T., et al
    • Journal Title

      Prog Neuro-Psychopharmacol & Biol Psychiatry 32

      Pages: 280-287

    • Peer Reviewed
  • [Journal Article] Effect of buspirone, a serotonin_<1A> partial agonist, on cognitive function in schizophrenia : A randomized, placebo-controlled, double-blind study2007

    • Author(s)
      Sumiyoshi T., et al
    • Journal Title

      Schizophr Res 95

      Pages: 158-168

    • Peer Reviewed
  • [Journal Article] Voxel-based analysis of P300 electrophysiological topography associated with positive and negative symptoms of schizophrenia2007

    • Author(s)
      Kawasaki Y., Sumiyoshi T., et al
    • Journal Title

      Schizophr Res 94

      Pages: 164-171

    • Peer Reviewed
  • [Journal Article] Effective adjunctive use of tandospirone with perospirone for enhancing verbal memory deficits and quality of life in schizophrenia2007

    • Author(s)
      Sumiyoshi T., et al
    • Journal Title

      Prog Neuro-Psychopharmacol & Biol Psychiatry 31

      Pages: 965-7

    • Peer Reviewed
  • [Presentation] Serotonin-1A receptors and cognitive enhancement in schizophrenia : Evidence from translational research. In Symposium "Serotonin receptors in endophenotypic variations and treatment of schizophrenia"2009

    • Author(s)
      Sumiyoshi T.
    • Organizer
      World Federation of Societies of Biological Psychiatry-9^<th> World Congress of Biological Psychiatry
    • Place of Presentation
      Paris
    • Year and Date
      2009-06-28
  • [Presentation] Role of serotonin-1A receptors in the treatment of memory disturbances in schizophrenia : Evidence from translational research. In Workshop "Memory and Schizophrenia : Molecular, Pharmacological and Neurocognitive Perspectives"2008

    • Author(s)
      Sumiyoshi T.
    • Organizer
      Society of Biological Psychiatry-63rd Annual Meeting
    • Place of Presentation
      Washington DC.
    • Year and Date
      2008-05-01
  • [Presentation] Serotonin-1A agonists as a cognitive enhancer in schizophrenia : Clinical evidence. In Symposium "The Role of 5-HT1A Receptors in the Pathophysiology and Treatment of Schizophrenia"2008

    • Author(s)
      Sumiyoshi T., et al.
    • Organizer
      16^<th> European Congress of Psychiatry
    • Place of Presentation
      Nice, France.
    • Year and Date
      2008-04-08
  • [Presentation] Neurocognitive assessment and pharmacotherapy : Towards prevention of psychosis. In Workshop "First Episode Psychosis : Integrating Neurobiological and Psychosocial determinants of outcome"2007

    • Author(s)
      Sumiyoshi T.
    • Organizer
      Society of Biological Psychiatry-62nd Annual Meeting
    • Place of Presentation
      San Diego
    • Year and Date
      2007-05-17
  • [Presentation] Neurocognitive assessment and pharmacotherapy : Towards prevention of psychosis. In Symposium "First Episode Psychosis : Integrating Neurobiological and Psychosocial determinants of outcome"2007

    • Author(s)
      Sumiyoshi T., et al
    • Organizer
      World Federation of Societies of Biological Psychiatry-The 2nd International Congress of Biological Psychiatry
    • Place of Presentation
      Santiago, Chile
    • Year and Date
      2007-04-20
  • [Book] Social Interactions in the 21^<st> Century(Heatherton A.T. and Walcott V.A. (Eds), Social interaction deficits in schizophrenia-spectrum disorders and pharmacologic intervention)2009

    • Author(s)
      Sumiyoshi T., et al.
    • Total Pages
      363-370
    • Publisher
      Nova Science Publishers Inc.
  • [Book] 「生体の科学」増大特集―神経伝達に関与する物質(伊藤正男、野々村禎昭、藤田道也, 編, 統合失調症の認知機能障害における5-HT受容体の役割)2009

    • Author(s)
      住吉太幹
    • Total Pages
      436-437
    • Publisher
      金原一郎記念医学医療振興財団

URL: 

Published: 2011-06-18   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi