2010 Fiscal Year Final Research Report
Investigation about the treatment of autism spectrum disorder using Animal model for autism.
| Project/Area Number |
19591350
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Nara Medical University |
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Principal Investigator |
SADAMATSU Miyuki Nara Medical University, 医学部, 准教授 (90252387)
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| Co-Investigator(Kenkyū-buntansha) |
KANAI Hirohiko 滋賀医科大学, 医学部, 講師 (30293830)
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| Co-Investigator(Renkei-kenkyūsha) |
MAKINODAN Manabu 奈良県立医科大学, 医学部, 助教 (00510182)
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| Project Period (FY) |
2007 – 2010
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| Keywords | 自閉症 / 甲状腺ホルモン / セロトニン / 小脳 |
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| Research Abstract |
I investigated about the possibility as the potential animal model for autism with operating thyroid hormone which plays an important role in the development of central nervous system. In the open-field tests, thyroid hormone β receptor knockout (TRβ(-/-)) mice exhibited a significant increase in locomotor activation. HPLC analysis revealed that TRβ(-/-) mice displayed a significant increase of dopamine concentrations in the striatum as well as in the nucleus accumbens. It was suggested that TRβ(-/-) mice might be as a potential animal model for attention-deficit hyperactivity disorder.
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