The examination of interaction between risk factors for dementia in cerebrovascular diseases and Alzheimer's disease-related factors

2008 Fiscal Year Final Research Report

• Project/Area Number: 19591353
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Osaka University
• Principal Investigator: FUKUNAGA Tomoko Osaka University, 医学系研究科, 助教 (90273630)
• Co-Investigator(Kenkyū-buntansha): MORIHARA Takashi 大阪大学, 医学系研究科, 助教 (90403196) ; UKAI Satoshi 和歌山県立医科大学, 医学部, 准教授 (80324763) ; NAGANO Keiko 大阪大学, 医学部附属病院, 医員 (90515959)
• Project Period (FY): 2007 – 2008
• Keywords: 認知症 / 脳血管障害 / アルツハイマー病 / 危険因子 / 認知機能 / 記憶

Research Abstract

脳血管障害から認知症に至る危険因子とアルツハイマー病関連因子との相互作用を認知機能と遺伝子から解明した。認知機能検査では、脳血管障害の論理的記憶の「記憶錯誤」と、アルツハイマー病の単語再認の「虚再認」とを検討し、記憶機能の詳細を明らかにした。脳血管障害のDNA検体のPPP2R2B遺伝子のSNPs解析では、アルツハイマー病と共通してPPP2R2Bがリスク遺伝子であるという結果であった。

Research Products

• [Journal Article] Dynamin 2 gene is a novelsusceptibility gene for late-onset Alzheimer disease in non-APOE-epsilon4 carriers (2008)
  • Author(s): Aidaralieva NJ, Kamino K, Kimura R, Yamamoto M, Morihara T, Kazui H, Hashimoto R, Tanaka T, Kudo T, Kida T, Okuda J, Uema T, Yamagata H, Miki T, Akatsu H, Kosaka K, Takeda M
  • Journal Title: carriers., J Hum Genet 53 Pages: 296-302
  • Peer Reviewed
• [Journal Article] Curcuminstructure-function, bioavailability, and efficacy in modelsof neuroinflammation andAlzheimer'sdisease (2008)
  • Author(s): Begum AN, Jones MR, Lim GP, Morihara T, Kim P, Heath DD, Rock CL, Pruitt MA,Yang F, Hudspeth B, Hu S, Faull KF, Teter B, Cole GM ,Frautschy SA
  • Journal Title: J Pharmacol ExpTher 326 Pages: 196-208
  • Peer Reviewed
• [Journal Article] Quantitative evaluation of carotid plaque echogenicity by integrated backscatter analysis (2008)
  • Author(s): Nagano K, Yamagami H,Tsukamoto Y, Nagatsuka K,Yasaka M, Nagata I, Hori M,Kitagawa K, Naritomi H
  • Journal Title: Correlatio with symptomatic history and histologicalfindings.、CerebrovascDis 26 Pages: 578-583
  • Peer Reviewed
• [Journal Article] 情動ストレス負荷に伴う脳機能の経時的変化 (2008)
  • Author(s): 林拓世、水野(松本)由子、岡本永佳、石井良平、鵜飼聡、篠崎和弘
  • Journal Title: 電子情報通信学会論文誌 91 Pages: 1874-1885
  • Peer Reviewed
• [Journal Article] 4大認知症の危険因子 (2007)
  • Author(s): 森原剛史、武田雅俊
  • Journal Title: 精神科治療学 22 Pages: 1373-1378
• [Journal Article] 認知症の脳磁図による評価 (2007)
  • Author(s): 鵜飼聡、篠崎和弘
  • Journal Title: 老年精神医学雑誌 18 Pages: 868-874
• [Presentation] Risk Genes for Dementia (2008)
  • Author(s): 森原剛史、シンポジウム
  • Organizer: 第51回神経化学大会
  • Place of Presentation: 富山
  • Year and Date: 20080911-13
• [Presentation] An Introduction of "Osaka University Rorschach System" (2008)
  • Author(s): Fukunaga T, Ishibash M, Aizawa N, Honaga E, Ogasawara M, Kawaguchi Y
  • Organizer: International Congress of Rorschach and Projective Methods
  • Place of Presentation: Berugium
  • Year and Date: 20080722-25
• [Presentation] ADAS. J. cog.の単語再認の検討-虚再認に注目して (2008)
  • Author(s): 竹内直子, 福永知子, 川口裕子, 松浦加奈, 鵜飼聡
  • Organizer: 第23回日本老年精神医学会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2008-06-28
• [Presentation] Neuropsychological test for the evaluation of dementia in elderly ; the Nishimura Dementia Test(ND test) (2007)
  • Author(s): Fukunaga T, Ukai S, et.al.
  • Organizer: The 13^<th> Congress of the International Psychogeriatrics association
  • Place of Presentation: Osaka
  • Year and Date: 20071014-18
• [Book] コア・ローティション精神科(改訂2版) (2007)
  • Author(s): 福永知子、金芳堂
  • Total Pages: 80-85,383-386