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2009 Fiscal Year Final Research Report

Relationship between polymorphisms of eNOS gene and depression

Research Project

  • PDF
Project/Area Number 19591385
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionUniversity of Occupational and Environmental Health, Japan

Principal Investigator

YOSHIMURA Reiji  University of Occupational and Environmental Health, Japan, 医学部, 准教授 (90248568)

Co-Investigator(Renkei-kenkyūsha) NAKAMURA Jun  産業医科大学, 医学部, 教授 (40148804)
GOTO Naoki  産業医科大学, 医学部, 助教 (60360278)
NAKANO Hideki  産業医科大学, 医学部, 訪問研究員 (20369060)
SUGITA Atsuko  産業医科大学, 医学部, 非常勤助教 (40421333)
Project Period (FY) 2007 – 2009
Keywords一酸化窒素 / 遺伝子多型 / うつ病
Research Abstract

Objective : We hypothesized that polymorphisms of eNOS gene are associated with pathogenesis of depression. To confirm the hypothesis, we examined the association of the polymorphisms of eNOS gene between patients with MDD. In addition, we also investigated the associations among the polymorphisms of eNOS gene among scores of HAMD and Beck Depression Inventory (BDI), ankle brachial index (ABI) and plasma NOx levels in depressed patients.
Materials and Methods : This study included 103 in- or outpatients in our university hospital who met the DSM-IV-TR criteria for MDD (M/F:41/62, age:44±13 years) and 104 age- and sex-matched healthy controls (M/F:37/66, age:39±16 years). Based on three polymorphism of eNOS gene (SNP; rs2070744, rs1799983, VNTR in intron 4), we conducted a genetic association analysis of case- control samples in patients with MDD or healthy controls in Japanese population. The plasma NOx levels were analyzed by the Griess method, using ENO-20. We used TaqMan assay for two SNPs, and the VNTR polymorphisms in intron 4 were determined by PCR-RFLP.
Results : We did not find genotype distributions between patients with MDD and healthy volunteers. No associations were observed between any polymorphisms of eNOS gene and HAMD, BDI, or ABI in patients with MDD. Conclusions : These results suggest that the three polymorphisms of eNOS gene might play little roles for the pathogenesis of depression.

  • Research Products

    (26 results)

All 2010 2009 2008

All Journal Article (15 results) (of which Peer Reviewed: 15 results) Presentation (11 results)

  • [Journal Article] Associattion between plasma nitric oxide metabolites levels and negative symptoms of schizophrenia:a pilot study.2010

    • Author(s)
      Nakano Y, Yoshimura R, et al.
    • Journal Title

      Hum Psychopharmacol 25

      Pages: 139-144

    • Peer Reviewed
  • [Journal Article] Serotonin 6 receptor gene and mood disorders:case control study and meta-analysis.2010

    • Author(s)
      Fukuo Y, Kishi T, Yoshimura R, et al.
    • Journal Title

      Neurosci Res (Epub ahead of print)

    • Peer Reviewed
  • [Journal Article] Association analysis of SIGMA 1 with major depressive disorder and SSRI response.2010

    • Author(s)
      Kishi T, Yoshimura R, et al.
    • Journal Title

      Neuropharmacol 58

      Pages: 1168-1173

    • Peer Reviewed
  • [Journal Article] Nonadrerence to paroxetine:a study based on monitoring plasma paroxetine levels.2010

    • Author(s)
      Yoshimura R, et al.
    • Journal Title

      J Clin Psychopharmacol 30

      Pages: 82-83

    • Peer Reviewed
  • [Journal Article] Adding a low dose atypical antipsychotic drug to an antidepressant induced a rapid increase of plasma brain-derived neurotrophic factor levels in patients with treatment-resistant depression.2010

    • Author(s)
      Yoshimura R, Ikenouchi-Sugita A, et al.
    • Journal Title

      P-N Biol Psychiatry 34

      Pages: 308-312

    • Peer Reviewed
  • [Journal Article] HTR2R is associated with SSRI response in major depressive disorder in a Japanese cohort.2009

    • Author(s)
      Kishi T, Yoshimura R, et al.
    • Journal Title

      Neuromolecular Med (Epub ahead of print)

    • Peer Reviewed
  • [Journal Article] Opposite effects of milnacipran, a serotonin norepinephrine reuptake inhibitor, on the levels of nitric oxide and brain-derived neurotrophic factor in mouse brain cortex.2009

    • Author(s)
      Ikenouchi-Sugita A, Yumiko T, Yoshimura R, et al.
    • Journal Title

      N-S Arch Pharmacol. N-S Arch Pharmacol 380

      Pages: 479-486

    • Peer Reviewed
  • [Journal Article] Predictive factors for responding to sertraline treatment:views from plasma catecholamine metabolite and serotonin transporter polymorphism.2009

    • Author(s)
      Umene-Nakano A, Yoshimura R, et al.
    • Journal Title

      J Psychopharmacol (Epub ahead of print)

    • Peer Reviewed
  • [Journal Article] Effects of antidepressants on plasma metabolites of nitric oxide in major metabolites of nitric oxide in major depressive disorder: comparison between milnacipran and paroxetine.2009

    • Author(s)
      Ikenouchi-Sugita A, Yoshimura R, et al.
    • Journal Title

      P-N Biol Psychiatry 33

      Pages: 1451-1453

    • Peer Reviewed
  • [Journal Article] Rapid response to paroxetine is associated with plasma paroxetine levels at 4 but not 8 weeks of treatment, and is independent of serotonin promoter polymorphism in Japanese depressed patients.2009

    • Author(s)
      Yoshimura R, et al.
    • Journal Title

      Hum Psychopharmacol 24

      Pages: 489-494

    • Peer Reviewed
  • [Journal Article] Serum levels of brain-derived neurotrophic factor in comorbidity of depression and alcohol dependence.2009

    • Author(s)
      Umene-Nakano W, Yoshimura R, et al.
    • Journal Title

      Hum Psychopharmacol 24

      Pages: 409-413

    • Peer Reviewed
  • [Journal Article] Higher interleukin-6(IL-6) level is associated with SSRI-or SNRI-refractory depression.2009

    • Author(s)
      Yoshimura R, et al.
    • Journal Title

      P-N Biol Psychiatry 33

      Pages: 722-726

    • Peer Reviewed
  • [Journal Article] How many well day vs. unwell days can you expect over 10 years, once you become depressed?2009

    • Author(s)
      Furukawa TA, Yoshimura R, et al.
    • Journal Title

      Acta Psychiatr Scand 119

      Pages: 290-297

    • Peer Reviewed
  • [Journal Article] Adding of risperidone to sertraline improves sertraline-resistant refractory depression without influencing plasma concentrations of sertraline and desmethylsertraline.2008

    • Author(s)
      Yoshimura R, et al.
    • Journal Title

      Hum Psychopharmacol 23

      Pages: 707-713

    • Peer Reviewed
  • [Journal Article] Efficacy of electroconvulsive therapy is associated with changing blood levels of homovanillic acid and brain-derived neurotrophic factor (BDNF) in refractory depressed patients:a pilot study.2008

    • Author(s)
      Okamoto T, Yoshimura R, et al.
    • Journal Title

      P-B Biol Psychiatry 32

      Pages: 1185-1190

    • Peer Reviewed
  • [Presentation] ミルナシプランが脳内の一酸化窒素動態および脳由来神経栄養因子の発現に与える影響.2009

    • Author(s)
      杉田篤子, 吉村玲児, ほか
    • Organizer
      第28回躁うつ病の薬理・生化学研究懇話会
    • Place of Presentation
      千歳
    • Year and Date
      20090000
  • [Presentation] セロトニン・ノルアドレナリン再取り込み阻害薬ミルナシプランの脳内NOSおよびBDNFに対する影響.2009

    • Author(s)
      豊平由美子, ほか
    • Organizer
      第62回日本薬理学会西南部会
    • Place of Presentation
      松山
    • Year and Date
      2009-11-20
  • [Presentation] Treatment with risperidone did not increase plasma nitric oxide metabolites levels in schizophrenic patients: a pilot study.2009

    • Author(s)
      Nakano Y, Yoshimura R, et al.
    • Organizer
      第19回日本臨床精神神経薬理学会
    • Place of Presentation
      京都
    • Year and Date
      2009-11-14
  • [Presentation] Varenicline did not increase serum BDNF levels in patients with nicotine dependence:a preliminary study.2009

    • Author(s)
      Nakano W, Yoshimura R, et al.
    • Organizer
      第19回日本臨床精神神経薬理学会
    • Place of Presentation
      京都
    • Year and Date
      2009-11-13
  • [Presentation] アルコール依存と脳由来神経栄養因子2009

    • Author(s)
      吉村玲児, ほか
    • Organizer
      第21回日本アルコール精神医学会
    • Place of Presentation
      横浜
    • Year and Date
      2009-09-07
  • [Presentation] Social Adoptation Self-evaluation Scale(SASS)日本語版のうつ病患者における臨床的有用性の検討.2009

    • Author(s)
      中野英樹, ほか
    • Organizer
      第105回日本精神神経学会学術総会
    • Place of Presentation
      神戸
    • Year and Date
      2009-08-21
  • [Presentation] Alcohol dependence and depression:views from dynamics of brain-derived neurotrophic factor and catecholamines.2009

    • Author(s)
      Nakano W, Yoshimura R, et al.
    • Organizer
      Korean Society of Biol Psychiatry
    • Place of Presentation
      Seoul
    • Year and Date
      2009-07-31
  • [Presentation] うつ病寛解後の抗うつ薬の服薬コンプライアンス:血中薬物濃度を指標とした検討.2009

    • Author(s)
      吉村玲児, ほか
    • Organizer
      第6回うつ病学会総会
    • Place of Presentation
      東京
    • Year and Date
      2009-07-31
  • [Presentation] うつ病寛解後の抗うつ薬の服薬アドヒアランス:血中薬物濃度を指標とした検討.2009

    • Author(s)
      吉村玲児, ほか
    • Organizer
      第28回躁うつ病の薬理・生化学研究懇話会
    • Place of Presentation
      千歳
    • Year and Date
      2009-07-10
  • [Presentation] うつ病とアルコール依存症での抑うつ症状に対する抗うつ薬の効果.臨床精神薬理学的予備的検討.2009

    • Author(s)
      中野和歌子, ほか
    • Organizer
      第31回日本生物学的精神医学会
    • Place of Presentation
      京都
    • Year and Date
      2009-04-25
  • [Presentation] 心血管病およびうつ病成員における一酸化窒素システムの意義.2009

    • Author(s)
      筒井正人, ほか
    • Organizer
      第82回日本薬理学会年会シンポジウム
    • Place of Presentation
      横浜
    • Year and Date
      2009-03-16

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Published: 2011-06-18   Modified: 2016-04-21  

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