An antidepressant related transcription factor Math2 regulates Prg1 expression and induces neurite differentiation.

2009 Fiscal Year Final Research Report

• Project/Area Number: 19591390
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: National Center of Neurology and Psychiatry
• Principal Investigator: YAMADA Misa National Center of Neurology and Psychiatry, 老人精神保健部, 科研費研究員 (10384182)
• Co-Investigator(Kenkyū-buntansha): YAMADA Mitsuhiko 国立精神・神経センター精神保健研究所, 老人精神保健部, 部長 (60240040) ; TAKAHASHI Kou 国立精神・神経センター精神保健研究所, 老人精神保健部, 外来研究員 (20415582)
• Project Period (FY): 2007 – 2009
• Keywords: 精神薬理学 / 抗うつ薬 / 転写因子 / 大脳皮質初代培養神経細胞 / 網羅的探索

Research Abstract

In the present study, we identified the gene, plasticity-related gene 1 (Prg1), targeted by a transcription factor Math2 which is an antidepressant related gene. Our results may support the hypothesis that Math2-Prg1 mediated plastic changes of nervous system in frontal cortex are involved with therapeutic action of antidepressants.

Research Products

• [Journal Article] Induction of the transcription factor Math2 and its target gene Prg1 after chronic treatment with selective serotonin reuptake inhibitors in rat brain. (2009)
  • Author(s): Yamada, M., Shida, Y., Takahashi, K., Yamada M.
  • Journal Title: J. Mental Health 55 Pages: 103-109
  • Peer Reviewed
• [Journal Article] Prg1 is regulated by the basic helix-loop-helix transcription factor Math2. (2008)
  • Author(s): Yamada, M., Shida, Y., Takahashi, K., Tanioka, T., Nakano, Y., Tobe, T., Yamada, M.
  • Journal Title: J. Neurochem 106 Pages: 2375-2384
  • Peer Reviewed
• [Presentation] 抗うつ薬の作用メカニズムに関わる転写因子ADRG701が制御する下流遺伝子の探索 (2007)
  • Author(s): 志田美子, 高橋弘, 山田美佐, 中野泰子, 戸部敞, 山田光彦
  • Organizer: 第30回日本分子生物学会年会, 第80回日本生化学会大会合同大会
  • Place of Presentation: パシフィコ横浜, 神奈川
  • Year and Date: 20071211-20071215
• [Presentation] An antidepressant related transcription factor Math2 regulates Prg1 expression and induces neurite differentiation.
  • Author(s): Yamada, M., Yamada, M., Shida, Y., Takahashi, K., Tanioka, T., Nakano, Y, Tobe, T.
  • Organizer: The 1st Meeting of the Asian College of Neuropsychopharmacology
  • Place of Presentation: 京都国際会議場Kyoto, Japan
  • Year and Date: 00001113-00001114