Development of a high precision system for detection of patients with Alzheimer's disease based on brain functional and morphological MR images

2009 Fiscal Year Final Research Report

• Project/Area Number: 19591423
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kyushu University
• Principal Investigator: ARIMURA Hidetaka Kyushu University, 大学院・医学研究院, 准教授 (20287353)
• Co-Investigator(Kenkyū-buntansha): YOSHIURA Takashi 九州大学, 大学病院, 講師 (40322747)
• Co-Investigator(Renkei-kenkyūsha): MONJI Akira 九州大学, 大学病院, 講師 (00294942)
• Project Period (FY): 2007 – 2009
• Keywords: アルツハイマー病 / MR画像 / 脳機能形態 / コンピュータ支援診断 / 画像解析

Research Abstract

We have developed a computer-aided diagnosis system for detection of patients with Alzheimer's disease based on the functional information (cerebral blood flow) obtained from perfusion MR images as well as the morphological information (cerebral cortical thickness and hippocampal volumes, etc) obtained from T1-wieghted MR images. The results presented in this study suggest that the proposed method might assist radiologists in the classification of patients with AD from normal subjects.

Research Products

• [Journal Article] Computer-aided classification of patients with dementia of Alzheimer's type based on cerebral blood flow determined with arterial spin labeling technique. (2010)
  • Author(s): Yamashita Y, Arimura H, Yoshiura T, Tokunaga C, Magome T, Monji A, Noguchi T, Toyofuku F, Ohki, M, Nakamura Y, Honda H.
  • Journal Title: SPIE Proceedings Vol.7624(印刷中)
• [Journal Article] Computer-Aided Evaluation Method of White Matter Hyperintensities Related to Subcortical Vascular Dementia Based on Magnetic Resonance (2010)
  • Author(s): Kawata Y, Arimura H, Yamashita Y, Magome T, Ohki M, Toyofuku F, Higashida Y, Tsuchiya K.
  • Journal Title: Computerized Medical Imaging and Graphics (in press)
  • Peer Reviewed
• [Journal Article] Computer-aided Diagnosis Systems for Brain Diseases in Magnetic Resonance Images. (2009)
  • Author(s): Arimura H, MagomeT, Yamashita Y, Yamamoto D
  • Journal Title: Algorithms Pages: 925-952
  • Peer Reviewed
• [Journal Article] Automated Method for Identification of Patients With Alzheimer's Disease Based on Three-dimensional MR Images. (2008)
  • Author(s): Arimura H, Yoshiura, Kumazawa S, Tanaka K, Koga H, Mihara F, Honda H, Sakai S, Toyofuku F, Higashida Y.
  • Journal Title: Academic Radiology Vol.15,No.3 Pages: 274-284
  • Peer Reviewed
• [Presentation] Computer-aided classification of patients with dementia of Alzheimer's type based on cerebral blood flow determined with arterial spin labeling technique. (2010)
  • Author(s): Yamashita Y, Arimura H, Yoshiura T, Tokunaga C, Magome T, Monji A, Noguchi T, Toyofuku F, Ohki, M, Nakamura Y, Honda H.
  • Organizer: SPIE Medical Imaging
  • Place of Presentation: San Diego, Town & Country
  • Year and Date: 2010-02-12
• [Presentation] Computerized evaluation method of white matter hyperintensities related to subcortical vascular dementia in brain MR images (2010)
  • Author(s): Arimura H, Kawata Y, Yamashita Y, Magome T, Ohki M, Toyofuku F, Higashida Y, Tsuchiya K.
  • Organizer: SPIE Medical Imaging
  • Place of Presentation: San Diego, Town & Country
  • Year and Date: 2010-02-12
• [Presentation] Development of Computer-aided Classification System for Patients with Dementia of Alzheimer Type Based on 3-D MR Atrophic image Features., Radiological Society of North America (2008)
  • Author(s): Arimura H, Yoshiura T, Uesugi M, Monji A, Mihara F, Honda H, Sakai S, Toyofuku F, Higashida Y.
  • Organizer: RSNA
  • Year and Date: 2008-11-30
• [Presentation] Computerized method for classification of patients with Alzheimer's disease based on segmentation of serebral cortical regions including hippocampal regions. (2008)
  • Author(s): Arimura H., Yoshiura T., Kumazawa S., Mihara F., Honda H., TanakaK., Koga H., Sakai S., Toyofuku F., Higashida Y.
  • Organizer: CARS
  • Year and Date: 2008-06-26
• [Book] 医用画像ハンドブック (2010)
  • Author(s): 有村秀孝, 他
  • Total Pages: 11
  • Publisher: オーム社
• [Remarks] ホームページ等
  • URL: http://www.shs.kyushu-u.ac.jp/~arimura/