2009 Fiscal Year Final Research Report
Non-invasive estimation of human iron load and its clinical application using T2* and T2 maps calculated from MR imaging
| Project/Area Number |
19591424
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Radiation science
|
|---|
| Research Institution | Fukuoka University (2008-2009)
Kyushu University (2007) |
|---|
Principal Investigator |
YOSHIMITSU Kengo Fukuoka University, 医学部, 教授 (20274467)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
HONDA Hiroshi 九州大学, 医学研究院, 教授 (90145433)
IRIE Hiroyuki 九州大学, 病院, 講師 (50284493)
TAJIMA Tsuyoshi 九州大学, 病院, 助教 (50346798)
NISHIE Akihiro 九州大学, 病院, 助教 (20457427)
HIRAKAWA Masakazu 九州大学, 医学研究院, 学術研究長 (20380454)
ISHIGAMI Kousei 九州大学, 病院, 助手 (10403916)
USHIJIMA Yasuhiro 九州大学, 病院, 助手 (40432934)
|
|---|
| Project Period (FY) |
2007 – 2009
|
| Keywords | 肝 / 鉄代謝 / T2*値 / T2値 |
|---|
| Research Abstract |
Newly developed T2* and T2 maps were clinically applied to patients with chronic liver diseases. As liver dysfunction progresses, T2* and T2 values of the liver decreased, representing intrinsic iron deposit. After SPIO, ΔT2*and ΔT2 also reduced, representing Kupffer cell dysfunction. Splenic signals were also correlated to liver dysfunction level. T2* and T2 maps were useful in assessing hepatosplenic condition in patients with chronic liver disease.
|
