2009 Fiscal Year Final Research Report
Optical and Nuclear Imaging of Tumor-related genes
Project/Area Number |
19591434
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Radiation science
|
Research Institution | Keio University |
Principal Investigator |
NAKAMURA Kayoko Keio University, 医学部, 共同研究員 (20124480)
|
Project Period (FY) |
2007 – 2009
|
Keywords | 放射線 / 遺伝子 / トランスレーショナルリサーチ / イメージング / 光生命科学 |
Research Abstract |
We have developed the simple preparation of Tc-99m-labeled or fluorophore-labeled nanoparticle which was reactive to mRNA in the tumor specifically. Nanoparticle consisted of Antisense-oligonucleotides and streptavidin or biotin. We have also developed second-generation nanoparticles which consisted of Antisense-oligonucleotides and streptavidin or biotin and monoclonal antibody which recognized the tumor specific receptor. HER2, which over expressed in the breast tumor implanted in the thigh of mouse, was viewed very clearly when Tc-99m-labeled nanoparticle was injected intravenously.
|
Research Products
(12 results)