2009 Fiscal Year Final Research Report
A novel chemoradiotherapy prolonging intratumoral retention of anticancer drugs by interrupting tumor blood flow
| Project/Area Number |
19591449
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Tohoku University |
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Principal Investigator |
HORI Katsuyoshi Tohoku University, 加齢医学研究所, 准教授 (00143032)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 放射線療法 / 抗癌剤 / 腫瘍血流遮断 / 治療効果増強 |
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| Research Abstract |
Drug delivery to tumor tissues was markedly enhanced by an increase in tumor blood flow accompanied with enhanced vascular permeability after irradiation. The increase in drug retention time in the tumor tissues was double at the maximum. Low molecular weight drugs (less than 4000) were washed out from the tumor tissue by diffusion even in the condition of complete tumor blood flow interruption. The most important finding obtained in the present study was that the timing of tumor blood flow interruption is a determinant influencing the efficacy of radiotherapy.
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