Novel therapeutic target for regulation of inflammation in tumor microenvironment

2009 Fiscal Year Final Research Report

• Project/Area Number: 19591493
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General surgery
• Research Institution: Wakayama Medical University
• Principal Investigator: IWAHASHI Makoto Wakayama Medical University, 医学部, 講師 (70244738)
• Co-Investigator(Kenkyū-buntansha): YAMAUE Hiroki 和歌山県立医科大学, 医学部, 教授 (20191190) ; NAKAMORI Mikihito 和歌山県立医科大学, 医学部, 講師 (10322372) ; NAKAMURA Masaki 和歌山県立医科大学, 医学部, 助教 (80364090) ; MATSUDA Kenji 和歌山県立医科大学, 医学部, 助教 (30398458)
• Project Period (FY): 2007 – 2009
• Keywords: 外科総論

Research Abstract

Expression of IL-17, IL-21 and IL-23 mRNA was found to be significantly up-regulated in tumor tissues compared with adjacent normal tissues. The expression level of IL-17 mRNA correlated with that of IL-21 and IL-23 mRNA in tumor tissue. The expression level of IL-17 mRNA in gastric tumors was associated with the depth of the tumors, suggesting that IL-17 obviously was related to tumor progression.

Research Products

• [Journal Article] High CCR7 mRNA expression of cancer cells is associated with lymph node involvement in patients with esophageal squamous cell carcinoma. (2009)
  • Author(s): Ishida K, Iwahashi M, Nakamori M, Nakamura M, Yokoyama S, Iida T, Naka T, Nakamura Y, Yamaue H.
  • Journal Title: Int J Oncol 34 Pages: 915-922
  • Peer Reviewed
• [Journal Article] Dendritic cells with transduced surviving gene induce specific cytotoxic T lymphocytes in human urologic cancer cell lines. (2009)
  • Author(s): Kikkawa K, Fujii R, Kuramoto T, Inagaki T, Kohjimoto Y, Iwahashi M, Yamaue H, Hara I.
  • Journal Title: Urology 74 Pages: 222-228
  • Peer Reviewed
• [Journal Article] Streptococcal preparation OK-432 promotes the capacity of dendritic cells (DCs) to prime carcinoembryonic antigen (CEA)-specific cytotoxic T lymphocyte responses induced with genetically modified DCs that express CEA. (2008)
  • Author(s): Ojima T, Iwahashi M, Nakamura M, Matsuda K, Nakamori M, Ueda K, Naka T, Katsuda M, Miyazawa M, Iida T, Yamaue H.
  • Journal Title: Int J Oncol 32 Pages: 459-466
  • Peer Reviewed
• [Journal Article] (2008)
  • Author(s): Naka T, Iwahashi M, Nakamura M, Ojima T, Nakamori M, Ueda K, Kastuda M, Miyazawa M, Ishida K, Yamaue H.
  • Journal Title: Cancer Sci 99 Pages: 407-413
  • Peer Reviewed
• [Presentation] Tumor-infiltrating CD4+ T cells secreting IL-17 Th17 promotes tumor growth in human gastric cancer. (2009)
  • Author(s): 飯田武
  • Organizer: 第68回日本癌学会定期学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-03
• [Presentation] Expression of interleukin-17 were associated with tumor progression in gastric cancer. (2008)
  • Author(s): 飯田武
  • Organizer: 第67回日本癌学会定期学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-28
• [Presentation] Distribution of regulatory T cells in tumor draining lympho node in patients with gastric cancer. (2007)
  • Author(s): 飯田武
  • Organizer: 第6 6回日本癌学会定期学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2007-10-05
• [Book] Cancer Treatment Navigator (2008)
  • Author(s): 岩橋誠
  • Total Pages: 38-39
  • Publisher: メディカルレビュー社
• [Remarks]
  • URL: http://www.wakayama-med.ac.jp/