Investigation of clinically used drugs for inhlbltlon of graft rejection and generation of reguIatory cells

2008 Fiscal Year Final Research Report

• Project/Area Number: 19591495
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General surgery
• Research Institution: Teikyo University
• Principal Investigator: NIIMI Masanori Teikyo University, 医学部, 准教授 (80198415)
• Project Period (FY): 2007 – 2008
• Keywords: 移植外科学

Research Abstract

MMFとラバマイシンが免疫制御細胞を誘導した.また、免疫抑制剤ではない通常薬剤ではウルソデオキシコール酸、ラジカット、塩酸サルポグレラート、柴苓湯が免疫制御細胞を誘導した。

Research Products

• [Journal Article] Prolonged Survival of Fully Mismatched Cardiac Allografts and Generation of Regulatory Cells by Sairei-to a Japanese Herbal Medicine Transplantation (2009)
  • Author(s): M. Niimi
  • Peer Reviewed
• [Journal Article] Purified Eicosapentaenoic Acid Induces Prolonged Survival of Cardiac Allografts and Generates Regulatory T Cells American Journal of Transplantation (2009)
  • Author(s): M. Niimi
• [Presentation] Administration of donor alloantigen via the respiratory tract generates CD11C+ regulatory cells and induces hyporesponsiveness to fully allogeneic cardiac grafts (2008)
  • Author(s): N. Shirasugi, Q. Zhang, D. Iwami, O. Aramaki, and M. Niimi
  • Organizer: XXII International Congress of the Transplantation Society Sydney
  • Place of Presentation: Australia
  • Year and Date: 20080810-14, 20080813
• [Presentation] Induction of prolonged survival of fully allogeneic cardiac grafts and generation of regulatory cells by purified eicosapentaenoic acid (2008)
  • Author(s): D. Iwami, Q. Zhang, . Aramaki, N. K. Nonomura, Shirasugi, and M. Niimi
  • Organizer: XXII International Congress of the Transplantation Society Sydney
  • Place of Presentation: Australia
  • Year and Date: 20080810-14, 20080813
• [Presentation] Saireito, a Japanese herbal medicine, induces indefinite survival of fully mismatched cardiac allografts and generates regulatory cells in mice XXII International Congress of the Transplantation Society Sydney (2008)
  • Author(s): Q. Zhang, D. Iwami, O. Aramaki, K. Watanabe, A. Ishige, N. Shirasugi, and M. Niimi
  • Organizer: Australia
  • Year and Date: 20080810-14, 20080813
• [Presentation] Purified Eicosapentaenoic acid induces prolonged survival of fully allogeneic cardiac grafts and generates regulatory cells (2008)
  • Author(s): D. Iwami, Q. Zhang, O. Aramaki, N. K. Nonomura, Shirasugi, and M. Niimi
  • Organizer: 2008 American Transplant Congress Toronto
  • Place of Presentation: Canada
  • Year and Date: 2008-05-31