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2008 Fiscal Year Final Research Report

Development of new cancer-immunothereapy targeting cancer stem cells

Research Project

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Project/Area Number 19591509
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionKyushu University

Principal Investigator

FUMIAKI Tanaka  Kyushu University, 大学病院, 助教 (30332836)

Co-Investigator(Kenkyū-buntansha) HIROSHI Inoue  九州大学, 生体防御医学研究所, 共同研究員 (90203249)
SHINICHIROU Yoshitake  九州大学, 大学病院, 講師 (80315142)
Project Period (FY) 2007 – 2008
Keywords癌幹細胞 / 特異的認識 / 免疫治療
Research Abstract

消化器癌における癌幹細胞のマーカーを明らかにするとともに、その生物学的特徴を明らかにすることを第一目標として研究を行った。細胞周期を指標とした方法により癌幹細胞成分を抽出した。また、網羅的遺伝子発現解析により、癌幹細胞に特徴的な遺伝子候補を同定した。それらの遺伝子が癌幹細胞に対する新規免疫治療の実施に有用な分子である可能性が示唆された。

  • Research Products

    (17 results)

All 2009 2008 Other

All Journal Article (13 results) Presentation (3 results) Remarks (1 results)

  • [Journal Article] Over-and under-expressed microRNAs in human colorectal cance2009

    • Author(s)
      Motoyama K, Inoue H, Takatsuno Y,Tanaka F, Mimori K, Uetake H, Sugihara K, Mori M.
    • Journal Title

      Int J Oncol 34

      Pages: 1069-75

  • [Journal Article] Clinical significanceof ApoE expression in human gastriccancer2008

    • Author(s)
      Sakashita K, Tanaka F, Zhang X, MimoriK, Kamohara Y, Inoue H, Sawada T,Hirakawa K, Mori M.
    • Journal Title

      Oncol Rep 20

      Pages: 1313-9

  • [Journal Article] Potential role of dendritic cell vaccination with MAGE peptides in gastrointestinal carcinomas2008

    • Author(s)
      Tanaka F, Haraguchi N, Isikawa K, InoueH, Mori M
    • Journal Title

      Oncol Rep 20

      Pages: 1111-1116

  • [Journal Article] Clinical significance of lowexpression of Prostasin mRNA in human gastric cancer2008

    • Author(s)
      Sakashita K, Mimori K, Tanaka F, TaharaK, Inoue H, Sawada T, Ohira M, HirakawaK, Mori M
    • Journal Title

      J Surg Oncol

      Pages: Epub ahead of print

  • [Journal Article] CD133+CD44+ population efficiently enriches colon cancer initiating cells2008

    • Author(s)
      Haraguchi N, Ohkuma M, Sakashita H, Matsuzaki S, Tanaka F, Mimori K, Kamohara Y, Inoue H, Mori M.
    • Journal Title

      Ann Surg Oncol 15

      Pages: 2927-33

  • [Journal Article] The search for cancer stem cells in hepatocellular carcinoma2008

    • Author(s)
      Kamohara Y, Haraguchi N, Mimori K,Tanaka F, Inoue H, Mori M, Kanematsu T
    • Journal Title

      Surgery 144

      Pages: 119-24

  • [Journal Article] Mitotic centromere-associated kinesin is a novel marker for prognosis and lymph node metastasis in colorectal cancer2008

    • Author(s)
      Ishikawa K, Kamohara Y, Tanaka F,Haraguchi N, Mimori K, Inoue H, Mori M.
    • Journal Title

      Br J Cancer 3-98

      Pages: 1824-9

  • [Journal Article] PDGF-BB is a novel prognostic factor in colorectal cancer2008

    • Author(s)
      Nakamura Y, Tanaka F, Yoshikawa Y,Mimori K, Inoue H, Yanaga K, Mori M
    • Journal Title

      Ann Surg Oncol 15

      Pages: 2129-36

  • [Journal Article] Efficient identification of a novel cancer/testis antigen for immunotherapy using three-step microarray analysis2008

    • Author(s)
      Yokoe T, Tanaka F, Mimori K, Inoue H, Ohmachi T, Kusunoki M, Mori M.
    • Journal Title

      Cancer Res 15-68

      Pages: 1074-82

  • [Journal Article] Clinical significance of BMP7 in human colorectal cancer2008

    • Author(s)
      Motoyama K, Tanaka F, Kosaka Y,Mimori K, Uetake H, Inoue H, Sugihara K,Mori M.
    • Journal Title

      Ann Surg Oncol 15

      Pages: 1530-7

  • [Journal Article] Biological and Genetic Characteristics of Tumor-Initiating Cells in Colon Cancer2008

    • Author(s)
      Ieta K, Tanaka F, Haraguchi N, Kita Y, Sakashita H, Mimori K, Matsumoto T Inoue H, Kuwano H, Mori M.
    • Journal Title

      Ann Surg Oncol 15

      Pages: 638-48

  • [Journal Article] Prognostic value of tumor-infiltratingFOXP3(+)regulatory T cells in patientswith hepatocellular carcinoma2008

    • Author(s)
      Sasaki A, Tanaka F, Mimori K, Inoue H, Kai S, Shibata K, Ohta M, Kitano S, Mori M.
    • Journal Title

      Eur J Surg Oncol 34

      Pages: 173-9

  • [Journal Article] Clinicopathological significance of stanniocalcin 2(STC2)gene expression in colorectal cancer

    • Author(s)
      Ieta K , Tanaka F, Yokobori T, Kita Y,Haraguchi N, Mimori K, Kato H,Asao T, Inoue H, Kuwano H, Mori M
    • Journal Title

      Int J Cancer (in press)

  • [Presentation] 樹状細胞と癌抗原を用いた進行癌に対する癌ワクチン治療 ; 未来への工夫2008

    • Author(s)
      田中文明、横江 毅、石川健二、三森功士、田原光一郎、井上 裕、森 正樹
    • Organizer
      第70回日本臨床外科学会総会
    • Place of Presentation
      東京
    • Year and Date
      2008-11-29
  • [Presentation] 消化器癌への樹状細胞と癌抗原を用いた癌ワクチン治療 ; これまでとこれからへ2008

    • Author(s)
      田中文明、原口直紹、横江 毅、石川健二、三森功士、蒲原行雄、井上 裕、森正樹
    • Organizer
      第63回日本消化器外科学会総会、パネルディスカッション
    • Place of Presentation
      札幌
    • Year and Date
      2008-07-17
  • [Presentation] 消化器癌幹細胞を標的とした新規癌治療の開発2008

    • Author(s)
      田中文明、原口直紹、石川健二、三森功士、蒲原行雄、井上 裕、森 正樹
    • Organizer
      第108回日本外科学会定期学術集会
    • Place of Presentation
      長崎
    • Year and Date
      2008-05-16
  • [Remarks]

    • URL

      http://www.mib-beppu.kyushu-u.ac.jp/MIB_res/Surgery/

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Published: 2010-06-10   Modified: 2016-04-21  

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