Epigenetic marker in human breast cancer

2008 Fiscal Year Final Research Report

• Project/Area Number: 19591526
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General surgery
• Research Institution: Department of Clinical Research, National Hospital Organization Kure Medical Center
• Principal Investigator: MIYAMOTO Kazuaki Department of Clinical Research, National Hospital Organization Kure Medical Center, 呉医療センター臨床研究部, 室長 (30332373)
• Project Period (FY): 2007 – 2008
• Keywords: 乳癌

Research Abstract

エピジェネティックな異常に着目することにより乳癌の診断およびサブタイプマーカーを探索し以下の点について明らかにした。1)幹細胞形質維持に重要な腫瘍抑制遺伝子PTENのDNAメチル化異常を伴わない高頻度な発現低下、2)HER2陽性乳癌に特徴的な8種類の新規microRNA異常、3)幹細胞転写因子OCT4の乳癌における高頻度の発現亢進。

Research Products

• [Journal Article] Association between frequent CpG island methylation and HER2 amplification in human breast cancers (2009)
  • Author(s): Terada K, Okochi-Takada E, Akashi-Tanaka S, Mivamoto K, Taniyama K, Tsuda H, Asada K, Kaminishi M, Ushijima T
  • Journal Title: Carcinogenesis 30 Pages: 466-71
• [Journal Article] Clinicopathological analyses of triple negative breast cancer using surveillance data from the Registration Committee of the Japanese Breast Cancer Society
  • Author(s): Iwase H, Kurebayashi J, Tsuda H, Ohta T, Kurosumi M, Miyamoto K, Yamamoto Y, Iwase T.
  • Journal Title: Breast Cancer (in press)
• [Journal Article] PCR/RT-PCR
  • Journal Title: アトラス細胞診と病理診断医学書籍 (印刷中)
• [Journal Article] FCM
  • Journal Title: アトラス細胞診と病理診断医学書籍 (印刷中)
• [Presentation] 乳癌における多剤耐性遺伝子MDR1のエピジェネティックな異常 (2008)
  • Author(s): 吉田裕, 宮本和明
  • Organizer: 第6回日本臨床腫瘍学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 20080320-20080321
• [Presentation] 卵巣がんにおける腫瘍抑制遺伝子RUNX3のエピジェネティックな異常 (2007)
  • Author(s): 川土洋介, 宮本和明, 他
  • Organizer: 第45回日本癌治療学会総会
  • Place of Presentation: 京都
  • Year and Date: 20071024-20071026
• [Presentation] Association between the CpG island methylator phenotype and clinicopathological findings in human breast cancers (2007)
  • Author(s): Terada k, Miyamoto K, et al.
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 20071003-20071005
• [Presentation] Epigenetic alteration of SMAD4 in human breast, lung, and ovarian cancers (2007)
  • Author(s): Saito A, Miyamoto K, et al.
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 20071003-20070105
• [Presentation] MDFI (MyoD family inhibitor), which regulates myogenic and Wnt/β-catenin signaling pathways, is inactivated in human breast cancer by epigenetic gene silencing (2007)
  • Author(s): Miyamoto K, et al.
  • Organizer: The 98th Annual Meeting of the American Association for Cancer Research.
  • Place of Presentation: Los Angeles, CA
  • Year and Date: 20070414-20070418