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2008 Fiscal Year Final Research Report

Telomerase specific oncolytic virotherapy to purge lymph node metastasis for minimizing invasiveness of gastrointestinal surgery

Research Project

  • PDF
Project/Area Number 19591543
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionOkayama University

Principal Investigator

KAGAWA Syunsuke  Okayama University, 医学部・歯学部附属病院, 助教 (00362971)

Co-Investigator(Kenkyū-buntansha) FUJIWARA Toshiyoshi  岡山大学, 医学部・歯学部附属病院, 准教授 (00304303)
Project Period (FY) 2007 – 2008
Keywords癌 / 転移 / アデノウイルス / テロメラーゼ / ウイルス療法
Research Abstract

これまで癌細胞を選択的に破壊するウイルス製剤テロメライシンの研究開発をおこなってきた。消化器癌治療における病態に応じた低侵襲手術の実現を目指し、癌のリンパ節転移に対するテロメライシンの治療効果を検討した。癌の原発巣に投与したテロメライシンはリンパ流に乗ってリンパ節に到達し、転移病巣内で治療効果を発揮することが確認された。テロメライシンは癌の原発巣とともにリンパ節転移をも治療できる可能性が示された。

  • Research Products

    (9 results)

All 2009 2008 2007

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (5 results)

  • [Journal Article] A novel antiangiogenic effect for telomerasespecific virotherapy through host immune system2009

    • Author(s)
      Ikeda Y, Kojima T, Kuroda S, Endo Y, Sakai R, Hioki M, Kishimoto H, Uno F, Kagawa S, Watanabe Y, Hashimoto Y, Urata Y, Tanaka N, Fujiwara T
    • Journal Title

      Journal of Immunology 182

      Pages: 1763-1769

    • Peer Reviewed
  • [Journal Article] Combination of oncolytic adenovirotherapy and Bax gene therapy in human cancer xenografted models2008

    • Author(s)
      Hioki M, Kagawa S, Fujiwara T, Sakai R, Kojima T, Watanabe Y, Hashimoto Y, Uno F, Tanaka N, Fujiwara T
    • Journal Title

      Potential merits and hurdles for combination therapy, International Journal of Cancer 122

      Pages: 2628-2633

    • Peer Reviewed
  • [Journal Article] Virus-mediated oncolysis induces danger signal and stimulates cytotoxic T-lymphocyte activity via proteasome activator upregulation2008

    • Author(s)
      Endo Y, Sakai R, Ouchi M, Onimatsu H, Hioki M, Kagawa S, Uno F, Watanabe Y, Urata Y, Tanaka N, Fujiwara T
    • Journal Title

      Oncogene 27

      Pages: 2375-2381

    • Peer Reviewed
  • [Journal Article] Establishment of biological and pharmacokinetic assays of telomerasespecific replication-selective adenovirus2008

    • Author(s)
      Hashimoto Y, Watanabe Y, Shirakiya Y, Uno F, Kagawa S, Kawamura H, Nagai K, Tanaka N, Kumon H, Urata Y, Fujiwara T
    • Journal Title

      Cancer Science 99

      Pages: 385-390

    • Peer Reviewed
  • [Presentation] テロメラーゼ特異的腫瘍融解ウイルスによる大腸がんモデルにおけるリンパ節内転移癌細胞の粛清効果の検討2008

    • Author(s)
      児島亨
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      愛知県名古屋市
    • Year and Date
      2008-10-29
  • [Presentation] In vivo biological purging of lymph node metastasis by Telomerase-specific oncolytic virus in an orthotopic human colorectal cancer model2008

    • Author(s)
      Toru Kojima
    • Organizer
      AACR 99th Annual Meeting
    • Place of Presentation
      San Diego, 米国
    • Year and Date
      2008-04-14
  • [Presentation] Telomerase-specific virotherapy targeting lymph node micrometastasis of human cancer2007

    • Author(s)
      児島亨
    • Organizer
      第66回日本癌学会学術総会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2007-10-03
  • [Presentation] Telomerase-specific virotherapy targeting lymph node metastasis of gastrointestinal cancer2007

    • Author(s)
      Toru Kojima
    • Organizer
      10th Annual Meeting of American Society of Gene Therapy
    • Place of Presentation
      Washington, 米国
    • Year and Date
      2007-06-01
  • [Presentation] 消化器癌の微小リンパ節転移を標的とする新規ウイルス製剤OBP-301による治療法の開発2007

    • Author(s)
      児島亨
    • Organizer
      第107回日本外科学会定期学術集会
    • Place of Presentation
      大阪府大阪市
    • Year and Date
      2007-04-11

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Published: 2010-06-10   Modified: 2016-04-21  

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