2009 Fiscal Year Final Research Report
Molecular targeting therapy of VEGF and PDGF receptor for colon cancer
| Project/Area Number |
19591556
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Osaka City University |
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Principal Investigator |
YAMADA Nobuya Osaka City University, 大学院・医学研究科, 講師 (00305640)
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| Co-Investigator(Kenkyū-buntansha) |
YASHIRO Masakazu 大阪市立大学, 大学院・医学研究科, 准教授 (60305638)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 小腸大腸肛門外科学 |
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| Research Abstract |
Ki23057 is a new small-synthetic tyrosine kinase inhibitor that blocks autophosphorylation of the VEGF receptor2 (VEGFR2). Ki23057 inhibited VEGF-induced proliferation of human umbilical vein endothelial cells (HUVECs), whereas no inhibitory effect of Ki23057 on the proliferation of colon cancer cells was observed by means of the cell count assay. Ki23057 inhibited tube formation of HUVECs and tyrosine phosphorylation of VEGFR2 in HUVECs. Ki23057 exhibited a significant inhibitory effect on the growth of the xenografted tumors and the spreading of cancer cells to liver. Ki23057 may be a promising new antiangiogenic agent for colon cancer.
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