2009 Fiscal Year Final Research Report
The nervous system structure of the bile duct in patients with choledochal cyst and a study of the neurotransmitter.
| Project/Area Number |
19591584
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Nagoya University |
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Principal Investigator |
ANDO Hisami Nagoya University, 大学院・医学系研究科, 教授 (60184321)
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| Co-Investigator(Kenkyū-buntansha) |
ONO Yasuyuki 名古屋大学, 医学部附属病院, 講師 (10378193)
TAINAKA Takahisa 名古屋大学, 医学部附属病院, 病院助教 (30378195)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 先天性胆道拡張症 / 胆管拡張機序 / 胆嚢壁神経叢 / 血管周囲神経叢 |
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| Research Abstract |
This study analyzed the bile duct walls of patients with choledochal cyst (CBD) as to whether the nerve fibers and nerve cells in the wall are abnormal or not. Bile ducts obtained from eight patients with choledochal cyst and seven normal bile ducts without dilatation were studied. The intramural vascularity in the gallbladders of the CBD group was significantly lower than that in the control group. The rate of perivascular plexuses on the surface of intramural vessels was also significantly lower in the CBD group than in the controls. There may be a mechanism in CBD causing contractile failure and dilatation of the biliary tract as a result of decreased intramural blood flow that accompanies the diminished vascularity.
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[Journal Article] Papillary hyperplasia of the gallbladder in pancreaticobiliary maljunction represents a senescence-related lesion induced by lysolecithin.2009
Author(s)
J. Yamaguchi, M. Sasaki, K. Harada, Y. Zen, Y. Sato, H. Ikeda, K. Itatsu, Y. Yokoyama, H., o, T. Ohta, A. Kubota, K. Shimizu, Y. Nimura, M. Nagino, Y. Nakanuma
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Journal Title
Laboratory Investigation 89
Pages: 1018-1031
Peer Reviewed
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