• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2009 Fiscal Year Final Research Report

Identification of Perpetuating Factor for Liver Tissue Inflammation in Hepatic Carcinogenesis

Research Project

  • PDF
Project/Area Number 19591595
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionKagoshima University

Principal Investigator

UENO Shinichi  Kagoshima University, 大学院・医歯学総合研究科, 准教授 (40322317)

Co-Investigator(Kenkyū-buntansha) AIKOU Takashi  鹿児島大学, 大学院・医歯学総合研究科, 教授 (60117471)
ABEYAMA Kazuhiro  鹿児島大学, 大学院・医歯学総合研究科, 客員研究員 (30284897)
MARUYAMA Ikurou  鹿児島大学, 大学院・医歯学総合研究科, 教授 (20082282)
SAKODA Masahiko  鹿児島大学, 医学部・歯学部附属病院, 医員 (40418851)
Project Period (FY) 2007 – 2009
KeywordsRAGE / HMGB1 / HCC / Esophageal ca / Carcinogenseis
Research Abstract

1) The expression of RAGE mRNA was lower in normal liver than in hepatitis and highest in HCC. Furthermore, in HCC, it was high in well- and moderately differentiated tumors but declined as tumors dedifferentiated to poorly differentiated HCC. Furthermore, HCC lines resistant to hypoxia were found to have higher levels of RAGE expression, and RAGE transfectant also showed significantly prolonged survival under hypoxia. Our results suggest that HCC during the early stage of tumorigenesis with less blood supply may acquire resistance to stringent hypoxic milieu by hypoxia-induced RAGE expression. 2) Loss of RAGE expression may play an important role in the progression of esophageal squamous cell carcinoma. Evaluation of the expression of RAGE could be useful for determining the tumor properties, including those associated with prognosis, in patients with esophageal squamous cell carcinoma. 3) The presence of RAGE might suppress HIF-1a protein expression, which in turn might induce an anti-apoptosis effect in RAGE-transfected Cos7 cells. Moreover, the p53 suppression induced by HIF-1a may lead to malignant potential in RAGE-transfected Cos7 cells.

  • Research Products

    (18 results)

All 2010 2009 2008 2007

All Journal Article (8 results) Presentation (10 results)

  • [Journal Article] Prognostic value of CD208-positive cell infiltration in gastric cancer.2010

    • Author(s)
      Ishigami S, Ueno S, et al
    • Journal Title

      Cancer Immnol Immunother 59

      Pages: 389-395

  • [Journal Article] Strong Smad4 expression correlates with poor prognosis after surgery in patients with hepatocellular carcinoma.2009

    • Author(s)
      Hiwatashi K, Ueno S, et al
    • Journal Title

      Ann Surg Oncol 16

      Pages: 3176-82

  • [Journal Article] Expression of receptor for advanced glycation end products (RAGE) is related to prognosis in patients with esophageal squamous cell carcinoma.2009

    • Author(s)
      Tateno T, Ueno S, et al
    • Journal Title

      Ann Surg Oncol 16

      Pages: 440-446

  • [Journal Article] Significance of M2-Polarized Tumor-Associated Macrophage in Pancreatic Cancer.2009

    • Author(s)
      Kurahara H, Sakoda M, Ueno S, et al
    • Journal Title

      J Surg Res 16

  • [Journal Article] Relevance of apoptosis and tolerance to hypoxic stress in cells transfected with receptor for advanced glycation end products (RAGE).2009

    • Author(s)
      Hiwatashi K, Ueno S, et al
    • Journal Title

      Anticancer Res 29

      Pages: 1287-1294

  • [Journal Article] Surgery for hepatocellular carcinoma located in the caudate lobe.2009

    • Author(s)
      Sakoda S, Ueno S, et al
    • Journal Title

      World J Surg 33

      Pages: 1922-1926

  • [Journal Article] Surgical resection versus radiofrequency ablation for small hepatocellular carcinomas within the Milan criteria.2009

    • Author(s)
      Ueno S, Sakoda M, Kubo F, et al
    • Journal Title

      J Hepatobiliary Pancreat Surg 16

      Pages: 359-366

  • [Journal Article] Efficacy of anatomic resection vs nonanatomic resection for small nodular hepatocellular carcinoma based on gross classification.2008

    • Author(s)
      Ueno S, Kubo F, Sakoda M, et al
    • Journal Title

      J Hepatobiliary Pancreat Surg 15

      Pages: 493-500

  • [Presentation] 膵頭部癌におけるReceptor for Advanced Glycation End Products‘RAGE)発現とその意義2009

    • Author(s)
      立野太郎, 上野真一, 他
    • Organizer
      第64回日本消化器外科学会
    • Place of Presentation
      大阪市
    • Year and Date
      20090700
  • [Presentation] 膵頭部癌の微小環境形成におけるtumor-associated macrophageの意義2009

    • Author(s)
      蔵原弘, 上野真一, 他
    • Organizer
      第109回日本外科学会
    • Place of Presentation
      東京
    • Year and Date
      20090400
  • [Presentation] RAGE発現細胞の低酸素耐性能はHIF, P53発現抑制により得られる.2008

    • Author(s)
      樋渡清司、上野真一, 他
    • Organizer
      第19回日本消化器癌発生学会
    • Place of Presentation
      別府市
    • Year and Date
      20080800
  • [Presentation] 食道扁平上皮癌発癌段階におけるReceptor for Advanced Glycation End Products‘RAGE)発現の検討2008

    • Author(s)
      立野太郎, 上野真一, 他
    • Organizer
      第19回日本消化器癌発生学会
    • Place of Presentation
      別府市
    • Year and Date
      20080800
  • [Presentation] 胸部食道扁平上皮癌発癌と進展におけるReceptor for Advanced Glycation End Products‘RAGE)発現とその意義2008

    • Author(s)
      立野太郎, 上野真一, 他
    • Organizer
      第63回日本消化器外科学会
    • Place of Presentation
      札幌市
    • Year and Date
      20080700
  • [Presentation] 食道扁平上皮癌発癌と進展におけるReceptor for Advanced Glycation End Products‘RAGE)発現とその意義2008

    • Author(s)
      立野太郎, 上野真一, 他
    • Organizer
      第108回日本外科学会
    • Place of Presentation
      長崎市
    • Year and Date
      20080500
  • [Presentation] RAGE発現は低酸素環境下での癌細胞の生存に寄与する2007

    • Author(s)
      樋渡清司, 上野真一, 他
    • Organizer
      第18回日本消化器癌発生学会
    • Place of Presentation
      札幌市
    • Year and Date
      20071100
  • [Presentation] 食道扁平上皮癌発癌と進展におけるReceptor for Advanced Glycation End Products‘RAGE)発現とその意義2007

    • Author(s)
      立野太郎, 上野真一, 他
    • Organizer
      第18回日本消化器癌発生学会
    • Place of Presentation
      札幌
    • Year and Date
      20071100
  • [Presentation] 膵頭部癌におけるmidkine発現の意義と血管新生への関与について2007

    • Author(s)
      前田真一, 上野真一, 他
    • Organizer
      第62回日本消化器外科学会
    • Place of Presentation
      東京
    • Year and Date
      20070700
  • [Presentation] Receptor for Advanced Glycation End-products(RAGE)発現により低酸素環境下での耐性並びに肝細胞癌での発現が増強する2007

    • Author(s)
      樋渡清司, 上野真一, 他
    • Organizer
      第107回日本外科学会
    • Place of Presentation
      東京
    • Year and Date
      20070400

URL: 

Published: 2011-06-18   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi