Copy number analysis for stepwise hepatocarcinogenesis using early hepatocellular carcinoma

2008 Fiscal Year Final Research Report

• Project/Area Number: 19591601
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Teikyo University
• Principal Investigator: MIDORIKAWA Yutaka Teikyo University, 医学部, 講師 (10292905)
• Project Period (FY): 2007 – 2008
• Keywords: 遺伝子 / 癌 / ゲノム / 病理学 / マイクロアレイ

Research Abstract

わが国における肝細胞癌の90%以上の症例は肝炎ウィルス罹患による慢性肝疾患を発生母地としており、前癌病変である再生結節や腺腫様過形成から早期肝癌へと移行する。本研究ではSNPアレイを用いたコピー数解析法により早期肝癌から進行肝癌へと進展する過程での染色体変化を明らかにし、また肝癌進展に寄与する癌抑制遺伝子CSMD1を同定し、同遺伝子のプロモーター領域におけるメチル化による不活化が重要であることを示した。

Research Products

• [Journal Article] Allelic imbalances and homozygous deletion on 8p23. 2 for stepwise progression of hepatocarcinogenesis (2009)
  • Author(s): Midorikawa Y, Yamamoto S, Tsuji S, Kamimura N, Ishikawa S, Igarashi H, Makuuchi M, Kokudo N, Sugimura H, Aburatani H
  • Journal Title: Hepatology 49 Pages: 513-22
• [Journal Article] Copy number estimation algorithms and fluorescence in situ hybridization to describe copy number alterations in human tumors (2009)
  • Author(s): Suzuki M, Nagura K, Igarashi H, Tao H, Midorikawa Y, Kitayama Y, Sugimura H
  • Journal Title: Pathol Int 59 Pages: 218-28
• [Journal Article] A human homolog of Notum, over-expressed in hepatocellular carcinoma, is transcriptionally regulated by ss-catenin/TCF (2008)
  • Author(s): Torisu Y, Watanabe A, Nonaka A, Midorikawa Y, Makuuchi M, Shimamura T, Sugimura H, Niida A, Akiyama T, Iwanari H, Kodama T, Zeniya M, Aburatani H
  • Journal Title: Cancer Sci 99 Pages: 1139-16
• [Journal Article] Screening of liver-targeted drugs (2008)
  • Author(s): Midorikawa Y, Sugiyama Y, Aburatani H
  • Journal Title: Expert Opin Drug Discov 3 Pages: 643-54
• [Journal Article] Elevation of serum KL-6 mucin levels in patients with cholangiocarcinoma (2008)
  • Author(s): Xu H, Inagaki Y, Tang W, Guo Q, Wang F, Seyama Y, Midorikawa Y, Gai R, Kokudo N, Sugawara Y, Nakata M, Makuuchi M
  • Journal Title: Hepatogastroenterology 55 Pages: 2000-4
• [Journal Article] 非代償性肝硬変患者の栄養治療 (2008)
  • Author(s): 緑川蚕、村田宣夫、杉山保幸
  • Journal Title: 日門亢会誌 14(2) Pages: 164-166
• [Journal Article] High-resolution mapping of copy number aberrations and identification of target genes in hepatocellular carcinoma (2007)
  • Author(s): Midorikawa Y, Tang W, Sugiyama Y
  • Journal Title: Bioscience Trends 1 Pages: 26-32
• [Journal Article] A case of cystic duct drainage into the left intrahepatic duct and the importance of Laparoscopic Fundus-First-Cholecystectomy for prevention of bile duct injury (2007)
  • Author(s): Yamakawa T, Tianhua Z, Midorikawa Y, Ishiyama J, Takahashi K, Sugiyama Y
  • Journal Title: J Laparoscopic Adv Surg Tech 17 Pages: 662-5
• [Journal Article] Inflammatory pseudotumor of the spleen : clinical impact in surgical treatment (2007)
  • Author(s): Takamoto K, Midorikawa Y, Minagawa M, Makuuchi M
  • Journal Title: Bioscience Trends 1 Pages: 113-6
• [Presentation] Stepwise progression of allele imbalance in hepatocarcinogenesis with special reference to nodule-in-nodule appearance using decision tree analysis
  • Author(s): Yutaka Midorikawa, Shogo Yamamoto, Shingo Tsuji, Naoko Kamimura, Shumpei Ishikawa, Masatoshi Makuuchi, Hisaki Igarashi, Haruhiko Sugimura, Hiroyuki Aburatani
  • Organizer: 99th, American Association for Cancer Research
  • Place of Presentation: San Diego
• [Presentation] Integrated analysis of genetic and epigenetic alterations in liver cancer
  • Author(s): Genta Nagae, Atsushi kaneda, Shuichi Tsutsumi, Shumpei Ishikawa, Yutaka Midorikawa, Hiroyuki Aburatani
  • Organizer: 99th, American Association for Cancer Research
  • Place of Presentation: San Diego
• [Presentation] Prediction of efficacy of FOLFOX therapy for colorectal cancer patients using random forests analysis
  • Author(s): Yutaka Midorikawa, Yasuyuki Sugiyama, Shingo Tsuji, Koichi Yagi, Shogo Yamamoto, Kazuhiro Yoshida, Takao Takahashi, Hiroyuki Aburatani
  • Organizer: 100th, American Association for Cancer Research
  • Place of Presentation: Denver
• [Book] 肝癌のアレイ解析 (2008)
  • Author(s): 緑川泰、杉山保幸
  • Total Pages: 258-64
  • Publisher: 遺伝子医学MOOK