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2008 Fiscal Year Final Research Report

NKT cell-based immunotherapy for lung cancer

Research Project

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Project/Area Number 19591609
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Thoracic surgery
Research InstitutionChiba University

Principal Investigator

MOTOHASHI Shinichiro  Chiba University, 大学院・医学研究院, 准教授 (60345022)

Project Period (FY) 2007 – 2009
KeywordsNKT 細胞 / 免疫細胞療法 / 肺癌
Research Abstract

In vivoでのNKT 細胞活性化を目的としたaガラクトシルセラミドパルス樹状細胞(DC)療法後の腫瘍局所におけるNKT 細胞免疫系を解析した結果、DC 投与により活性化したNKT 細胞の腫瘍への浸潤が明らかに増強していることが判明した。さらにNKT 細胞免疫療法施行症例の末梢血を用いてcDNA microarray による遺伝子発現解析を行い、免疫反応の増強が認められた症例に特異的な複数の遺伝子発現変化を認めた。

  • Research Products

    (19 results)

All 2009 2008 2007

All Journal Article (11 results) (of which Peer Reviewed: 11 results) Presentation (8 results)

  • [Journal Article] Combination therapy of in vitro-expanded natural killer T cells and α-galactosylceramide-pulsed antigenpresenting cells in patients with recurrenthead and neck carcinoma2009

    • Author(s)
      Kunii, N., Horiguchi, S., Motohashi, S.,Yamamoto, H., Ueno, N., Yamamoto, S.,Sakurai, D., Taniguchi, M., Nakayama, T., and Okamoto, Ya
    • Journal Title

      Cancer Sci. (in press)

    • Peer Reviewed
  • [Journal Article] Invariantnatural killer T cell-based immunotherapy forcancer2009

    • Author(s)
      Motohashi, S., and Nakayama, T
    • Journal Title

      Immunotherapy 1

      Pages: 73-82

    • Peer Reviewed
  • [Journal Article] Naturalkiller T cell-mediated immunotherapy formalignant diseases2009

    • Author(s)
      Motohashi, S., and Nakayama, T
    • Journal Title

      Frontiers in BioscienceS 1

      Pages: 108-116 ,

    • Peer Reviewed
  • [Journal Article] A phase I-II study of-Galactosylceramide-pulsedIL-2/GM-CSF-cultured peripheral bloodmononuclear cells in patients with advancedand recurrent non-small cell lung cancer2009

    • Author(s)
      Motohashi, S., Nagato, K., Kunii, N.,Yamamoto, H., Yamasaki, K., Okita, K.,Hanaoka, H., Shimizu, N., Suzuki, M.,Yoshino, I., Taniguchi, M., Fujisawa, T., and Nakayama, T
    • Journal Title

      J.Immunol. 182(4)

      Pages: 2492-501

    • Peer Reviewed
  • [Journal Article] Human Th1differentiation induced bylipoarabinomannan/lipomannan fromMycobacterium bovis BCG Tokyo-1722008

    • Author(s)
      Ito, T., Hasegawa, A., Hosokawa, H.,Yamashita, M., Motohashi, S., Naka, T.,Okamoto, Y., Fujita, Y., Ishii, Y., Taniguchi,M., Yano, I., and Nakayama, T
    • Journal Title

      Int.Immunol 20(7)

      Pages: 849-860

    • Peer Reviewed
  • [Journal Article] Aberrantmethylation of CXCL12 in non-small celllung cancer is associated with an unfavorableprognosis2008

    • Author(s)
      Suzuki, M., Mohamed, S., Nakajima, T.,Kubo, R., Tian, L., Fujiwara, T., Suzuki, H.,Nagato, K., Chiyo, M., Motohashi, S.,Yasufuku, K., Iyoda, A., Yoshida, S., Sekine,Y., Shibuya, K., Hiroshima, K., Nakatani, Y.,Yoshino, I., Fujisawa, T
    • Journal Title

      Int. J. Oncol 33

      Pages: 113-9

    • Peer Reviewed
  • [Journal Article] Gfi1-mediated stabilization of GATA3protein is required for Th2 celldifferentiation2008

    • Author(s)
      Shinnakasu, R., Yamashita, M., Kuwahara,M., Hosokawa, H., Hasegawa, A.,Motohashi, S., Nakayama, T
    • Journal Title

      J Biol Chem

    • Peer Reviewed
  • [Journal Article] Phase I study ofα-galactosylceramide-pulsed antigenpresenting cells administration to thenasal submucosa in unresectable orrecurrent head and neck cancer2008

    • Author(s)
      Uchida, T., Horiguchi, S, Tanaka, Y.,Yamamoto, H., Kunii, N., Motohashi,S.,Taniguchi, M., Nakayama, T.,Okamoto,Y
    • Journal Title

      CancerImmunol Immunother 57(3)

      Pages: 337

    • Peer Reviewed
  • [Journal Article] Bmi1 regulates memory CD4T cell survival via repression of the Noxagene2008

    • Author(s)
      Yamashita, M., Kuwahara, M., Suzuki, A.,Hirahara, K., Shinnakasu, R., Hosokawa, H.,Hasegawa, A., Motohashi, S., Iwama, A., and Nakayama, T
    • Journal Title

      J. Exp. Med 205

      Pages: 110

    • Peer Reviewed
  • [Journal Article] Clinicalapplications of natural killer T cell-basedimmunotherapy for cance2008

    • Author(s)
      Motohashi, S., and Nakayama, T
    • Journal Title

      Cancer Sci 99

      Pages: 638-645

    • Peer Reviewed
  • [Journal Article] Synchronousalterations of Wnt and epidermal growthfactor receptor signaling pathways throughaberrant methylation and mutation in nonsmall cell lung cancer2007

    • Author(s)
      Suzuki, M., Shigematsu, H., Nakajima T.,Kubo, R., Motohashi, S., Sekine, Y., Shibuya,K., Iizasa, T., Hiroshima, K., Nakatani, Y.,Gazdar, AF., Fujisawa, T
    • Journal Title

      Clin Cancer Res 13(20)

      Pages: 6087-92

    • Peer Reviewed
  • [Presentation] A Phase I-II study of αGalCel-pulsedantigen presenting cells in patients withadvanced or recurrent non-small cell lungcancer2009

    • Author(s)
      Motohashi, S
    • Organizer
      The 5th International Symposium onCD1/NKT Cells
    • Place of Presentation
      鎌倉
    • Year and Date
      2009-03-29
  • [Presentation] cells after preoperativea-Galactosylceramide-pulsed dendritic celltreatment.2009

    • Author(s)
      本橋新一郎
    • Organizer
      千葉大学G-COE シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2009-01-06
  • [Presentation] 原発性肺癌に対するNKT細胞免疫系を標とした免疫細胞療法2008

    • Author(s)
      本橋新一郎
    • Organizer
      第32 回日本リンパ学会総会
    • Place of Presentation
      東京
    • Year and Date
      2008-06-06
  • [Presentation] Phase I/II study of α GalCer-pulsed dendriticcell in patients with advanced or recurrentnon-small cell lung cancer2008

    • Author(s)
      Motohashi, S
    • Organizer
      2008 American Society of Clinical Oncologynnual Meeting
    • Place of Presentation
      Chicago
    • Year and Date
      2008-05-29
  • [Presentation] Natural Killer T cell-based Immunotherapyfor Lung Cancer2008

    • Author(s)
      本橋新一郎
    • Organizer
      第12回基盤的癌免疫研究会
    • Place of Presentation
      大宮
    • Year and Date
      2008-01-03
  • [Presentation] Phase I/II study of αGalCer-pulsed dendriticcell in patients with advanced or recurrentnon-small cell lung cancer2007

    • Author(s)
      本橋新一郎
    • Organizer
      第66回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-03
  • [Presentation] 原発性肺癌に対するNKT細胞免疫系を標的にした免疫細胞療法2007

    • Author(s)
      本橋新一郎
    • Organizer
      第11回基盤的癌免疫研究会
    • Place of Presentation
      大宮
    • Year and Date
      2007-07-12
  • [Presentation] 原発性肺癌術後再発抑制を目的としたα-GalactosylCeramide パルス樹状細胞投与によるNKT 細胞免疫療法2007

    • Author(s)
      本橋新一郎
    • Organizer
      第107回日本外科学会定期学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2007-04-12

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Published: 2010-06-10   Modified: 2016-04-21  

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