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2009 Fiscal Year Final Research Report

Development of local regulation strategy for malignant pleural mesothelioma

Research Project

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Project/Area Number 19591629
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Thoracic surgery
Research InstitutionChiba University

Principal Investigator

YOSHINO Ichiro  Chiba University, 大学院・医学研究院, 教授 (40281547)

Co-Investigator(Kenkyū-buntansha) SHOUJI Fumifiro  九州大学, 大学院, 医員 (90444851)
KOMETANI Takurou  九州大学, 大学病院, 医員 (00452764)
YONEMITU Yoshikazu  九州大学, 大学院・医学研究院, 特任教授 (40315065)
Co-Investigator(Renkei-kenkyūsha) HOSHINO Hidehisa  千葉大学, 医学部附属病院, 助教 (90507188)
MORIYA Yasumitu  千葉大学, 医学部附属病院, 助教 (90375692)
Project Period (FY) 2007 – 2009
Keywords胸膜中皮腫 / 遺伝子治療 / 分子標的治療 / 糖代謝 / ヘキソキナーゼ / 遺伝子治療
Research Abstract

Malignant pleural mesothelioma is highly malignant, however, sometimes long-term survivor has been reported. In our clinical analysis, the conditions of the long-term survival were complete resection, short operative time and good PS although such patients with the conditions are estimated as approximately 20% of the patients. During establishment of the novel local therapy for the disease, siRNA interference of type II hexokinase gene was observed to suppress proliferative activity of mesothlioma cells. Inorder to establish stable gene therapy, in vitro transfection using Sendai virus vector has been tried.

  • Research Products

    (15 results)

All 2009 2008 2007

All Journal Article (11 results) (of which Peer Reviewed: 10 results) Presentation (4 results)

  • [Journal Article] Promoter hypermethylation of the p16 and Wif-1 genes as an independent prognostic marker in stage IA non-small cell lung cancers2009

    • Author(s)
      Yoshino M, Yoshino I, et al
    • Journal Title

      Int J Oncol 35(5)

      Pages: 1201-9

    • Peer Reviewed
  • [Journal Article] Prostaglandin E2 receptor 2 overexpression in squamous cell carcinoma of the lung correlates with p16INK4A methylation and an unfavorable prognosis2009

    • Author(s)
      Alaa M, Yoshino I, et al
    • Journal Title

      Int J Oncol. 34(3)

      Pages: 805-12

    • Peer Reviewed
  • [Journal Article] Malignant pleural mesothelioma : clinicopathology of 16 extrapleural pneumonectomy patients with special reference to early stage features2009

    • Author(s)
      Hiroshima K, Yoshino I, et al.
    • Journal Title

      Pathol Int 59(8)

      Pages: 537-45

    • Peer Reviewed
  • [Journal Article] Endobronchial ultrasound for diagnosis of synchronous primary lung cancers2009

    • Author(s)
      Wong MK, Yoshino I, et al.
    • Journal Title

      LungCancer 63(1)

      Pages: 154-7

    • Peer Reviewed
  • [Journal Article] Prediction of lymph node metastasis by gene expression profiling in patients with primary resected lung cancer2009

    • Author(s)
      Moriya Y, Iyoda A, Kasai Y, Sugimoto T, Hashida J, Nimura Y, Kato M, Takiguchi M, Fujisawa T, Seki N, Yoshino I
    • Journal Title

      LungCancer 64(1)

      Pages: 86-91

    • Peer Reviewed
  • [Journal Article] Upregulation of hypoxia-inducible factor-1alpha mRNA and itsclinical significance in non-small cell lung cancer2008

    • Author(s)
      Yohena T, Yoshino I, Takenaka T, Kameyama T, Ohba T, Kuniyoshi Y, Maehara Y
    • Journal Title

      Journal of ThoracicOncology 4(3)

      Pages: 284-90

    • Peer Reviewed
  • [Journal Article] Identification of microRNAs caused by DNA methylation that induce metastasis2008

    • Author(s)
      Suzuki M, Yoshino I
    • Journal Title

      Future Oncology 38(11)

      Pages: 993-8

  • [Journal Article] Diffuse malignant pleural mesothelioma : a multi-institutional clinicopathological study2008

    • Author(s)
      Iyoda A, Yusa T, Kadoyama C, Sasaki K, kimura H, Yamakawa H, Shiba M, Fujisawa T, Yoshino I
    • Journal Title

      SurgeryToday 38(11)

      Pages: 993-8

    • Peer Reviewed
  • [Journal Article] Combined evaluation of Rad51 and ERCC1 expressions for sensitivity to platinum agents in non-small cell lung2007

    • Author(s)
      Takenaka T, Yoshino I, Kouso H, Ohba T, Yohena T, Osoegawa A, Shoji F, Maehara Y
    • Journal Title

      International Journal of Cancer 121(4)

      Pages: 895-900

    • Peer Reviewed
  • [Journal Article] Induction of transition-related genes by benzo(a)pyrene in lung cancer cells2007

    • Author(s)
      Yoshino I, Kometani T, Shoji F, Osoegawa A, Ohba T, Kouso H, Takenaka T, Yohena T, Maehara Y
    • Journal Title

      Caner 110(2)

      Pages: 369-74

    • Peer Reviewed
  • [Journal Article] Relationship between the loss of heterozygosity and tobacco smoking in pulmonary adenocarcinoma2007

    • Author(s)
      Yohena T, Yoshino I, Takenaka T, Ohba T, Kouso H, Osoegawa A, Hamatake M, Oda S, Kuniyoshi Y, Maehara Y
    • Journal Title

      Oncology Report 16(7)

      Pages: 333-9

    • Peer Reviewed
  • [Presentation] 期悪性胸膜中皮腫の集学的治療における胸膜外肺全摘術の成績と意義2009

    • Author(s)
      吉野一郎, 由佐俊和, 門山周文, 木村秀樹, 斎藤幸雄, 柴光利, 山川久美
    • Organizer
      第26回日本呼吸器外科学会総会
    • Place of Presentation
      九州
    • Year and Date
      2009-05-13
  • [Presentation] 中皮腫-外科医よして何ができるか-2008

    • Author(s)
      吉野一郎
    • Organizer
      第147回日本胸部外科学会関東甲信越地方会
    • Place of Presentation
      東京
    • Year and Date
      2008-09-06
  • [Presentation] 切除可能胸膜中皮腫に対する集学的治療の意義2008

    • Author(s)
      吉野一郎
    • Organizer
      第49回日本臨床細胞学会
    • Place of Presentation
      東京
    • Year and Date
      2008-06-07
  • [Presentation] I-III期悪性胸膜中皮腫の集学的治療における胸膜外肺全摘術の意義2007

    • Author(s)
      吉野一郎, 他
    • Organizer
      第24回 日本呼吸器外科学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-05-18

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Published: 2011-06-18   Modified: 2016-04-21  

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