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2008 Fiscal Year Final Research Report

Development of a sensitive detection system of pleural dissemination and nodal metastases in lung cancer

Research Project

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Project/Area Number 19591652
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Thoracic surgery
Research InstitutionHyogo College of Medicine

Principal Investigator

TAKUWA Teruhisa  Hyogo College of Medicine, 医学部, 助教 (00412049)

Co-Investigator(Kenkyū-buntansha) TANAKA Fumihiro  兵庫医科大学, 医学部, 准教授 (10283673)
Project Period (FY) 2007 – 2008
Keywords呼吸器外科学 / 肺癌 / 遺伝子変異 / 胸膜播種 / リンパ節転移
Research Abstract

肺癌では手術で完全に病巣を取り除いても、顕微鏡で見つけることの出来ないような微小な癌病巣が体に残ることが多く、手術後の再発そして死亡につながる。今回の研究では、癌を切除したあとの胸の中(胸腔やリンパ節など)に小さな病巣が残っているかどうかを、遺伝子解析の手法を用いて検討した。その結果、遺伝子解析を用いても現在の顕微鏡レベルでの検査以上の高感度な癌病巣の検出は困難であることが判明した。

  • Research Products

    (17 results)

All 2009 2008 2007

All Journal Article (10 results) (of which Peer Reviewed: 8 results) Presentation (6 results) Book (1 results)

  • [Journal Article] Circulating tumor cells in pulmonary blood of primary lung cancer patients2009

    • Author(s)
      Okumura Y、Tanaka F、Yoneda K、Hashimoto M、Takuwa T、Kondo N、Hasegawa S
    • Journal Title

      Ann Thorac Surg 87巻

      Pages: 1669-1675

    • Peer Reviewed
  • [Journal Article] Monitoring with a non-invasive bioluminescent in vivo imaging system of pleural metastasis of lung carcinoma2009

    • Author(s)
      Matsumoto S、Tanaka F、Sato K、Kimura S、Maekawa T、Hasegawa S、Wada H
    • Journal Title

      Lung cancer (Web上で公開)

      Pages: 0

    • Peer Reviewed
  • [Journal Article] D2-40-positive lymphatic vessel density is a poor prognostic factor in squamous cell carcinoma of the lung2009

    • Author(s)
      Iwakiri S、Nagai S、Katakura K、Date H、 Wada H、Tanaka F
    • Journal Title

      Ann Thorac Surg 16巻

      Pages: 1678-1685

    • Peer Reviewed
  • [Journal Article] 肺癌オーダーメード治療の現況と今後の展望 : バイオマーカーに基づいた肺癌化学療法の個別化2009

    • Author(s)
      田中文啓、長谷川誠紀
    • Journal Title

      外科治療 100巻

      Pages: 235-241

  • [Journal Article] 肺がん分子標的治療・その後の展開 : 肺がんのアジュバント治療と分子標的2008

    • Author(s)
      田中文啓
    • Journal Title

      がん分子標的治療 5巻

      Pages: 195-205

  • [Journal Article] COPDを合併した肺癌症例に対する肺葉切除術 : チオトロピウム吸入の有用性2008

    • Author(s)
      多久和輝尚、松本成司、奥村好邦、田中文啓、長谷川誠紀
    • Journal Title

      Therapeutic Research 29巻

      Pages: 69-72

    • Peer Reviewed
  • [Journal Article] Schedule-dependent synergistic effect of pemetrexed combined with gemcitabine against malignant pleural mesothelioma and non-small cell lung cancer cell lines2008

    • Author(s)
      Nagai S、Takenaka K、Sonobe M、Wada H、Tanaka F
    • Journal Title

      Chemotherapy 54巻

      Pages: 166-175

    • Peer Reviewed
  • [Journal Article] Perimembrane Aurora-A expression is a significant prognostic factor in correlation with proliferative activity in non-small-cell lung cancer (NSCLC)2007

    • Author(s)
      Ogawa E、Takenaka K、Katakura H、AdachiM、Otake Y、Toda Y、Kotani H、Manabe T、Wada H、Tanaka F
    • Journal Title

      Ann Surg Oncol 15巻

      Pages: 547-554

    • Peer Reviewed
  • [Journal Article] Expression of tissue inhibitor of metalloproteinase-3 (TIMP-3) and its prognostic significance in resected non-small cell lung cancer2007

    • Author(s)
      Mino N、Takenaka K、Sonobe M、Miyahara R、Yanagihara K、Otake Y、Wada H、Tanaka F
    • Journal Title

      J Surg Oncol 95巻

      Pages: 250-257

    • Peer Reviewed
  • [Journal Article] Influence of epidermal growth factor receptor (EGFR) gene mutations on the expression of EGFR, phosphoryl-Akt, and phosphoryl-MAPK, and on the prognosis of patients with non-small cell lung cancer2007

    • Author(s)
      Sonobe M、Nakagawa M、Takenaka K、Katakura H、Adachi M、Yanagihara K、Otake Y、Wada H、Tanaka F
    • Journal Title

      J Surg Oncol 95巻

      Pages: 63-69

    • Peer Reviewed
  • [Presentation] Circulating tumor cell in peripheral blood (CTC) and pulmonary venous blood of patients with resected primary lung cancer2009

    • Author(s)
      anaka F
    • Organizer
      45th annual meeting of the Society of Thoracic Surgeons (STS)
    • Place of Presentation
      サンフランシスコ市(アメリカ合衆国)
    • Year and Date
      2009-01-26
  • [Presentation] 腺癌関連病変同時多発例の遺伝子学的検討2008

    • Author(s)
      多久和輝尚
    • Organizer
      日本肺癌学会総会
    • Place of Presentation
      小倉市
    • Year and Date
      2008-11-14
  • [Presentation] 各科領域における術後補助化学療法の現状:非小細胞肺癌における術後補助化学療法2008

    • Author(s)
      田中文啓
    • Organizer
      第46回日本癌治療学会総会
    • Place of Presentation
      名古屋市
    • Year and Date
      2008-11-01
  • [Presentation] Clinicopathological features in correlation with epidermal growth factor receptor mutation in non-small cell lung cancer (NSCLC)2007

    • Author(s)
      Tanaka F
    • Organizer
      43rd Annual Meeting of The American Society of Clinical Oncology (ASCO)
    • Place of Presentation
      シカゴ市(アメリカ合衆国)
    • Year and Date
      2007-06-02
  • [Presentation] EGFR/K-ras mutations in adenocarcinoma and atypical adenomatous hyperplasia (AAH)2007

    • Author(s)
      Takuwa T
    • Organizer
      43rd Annual Meeting of The American Society of Clinical Oncology (ASCO)
    • Place of Presentation
      シカゴ市(アメリカ合衆国)
    • Year and Date
      2007-06-02
  • [Presentation] FDG-PET in correlation with epidermal growth factor receptor gene mutations in resected non-small cell lung cancer (NSCLC)2007

    • Author(s)
      Tanaka F
    • Organizer
      98th annual meeting of the American Association for Cancer Research (AACR)
    • Place of Presentation
      ロサンゼルス市(アメリカ合衆国)
    • Year and Date
      2007-04-19
  • [Book] Annual Review呼吸器2007

    • Author(s)
      田中文啓
    • Total Pages
      211-230
    • Publisher
      中外医学社

URL: 

Published: 2010-06-10   Modified: 2016-04-21  

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