Analysis of tumor-specific immune response during progression and metastasis in lung cancer

2009 Fiscal Year Final Research Report

• Project/Area Number: 19591653
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Thoracic surgery
• Research Institution: University of Occupational and Environmental Health, Japan
• Principal Investigator: TAKENOYAMA Mitsuhiro University of Occupational and Environmental Health, Japan, 医学部, 講師 (10309966)
• Co-Investigator(Kenkyū-buntansha): YASUMOTO Kosei 産業医科大学, 医学部, 教授 (30150452) ; HANAGIRI Takeshi 産業医科大学, 医学部, 准教授 (30299614) ; YASUDA Manabu 産業医科大学, 医学部, 助教 (50352307)
• Project Period (FY): 2007 – 2009
• Keywords: 肺癌 / 免疫応答 / 転移 / 腫瘍抗原

Research Abstract

For the purpose of developing immunotherapy as new modalities against lung cancer patients with poor prognosis, it is necessary to elucidate tumor-specific immune responses during progression and metastasis of tumors. In this study, we succeeded in detecting several tumor-specific cytotoxic T lymphocytes against primary and metastatic lung cancer. Among them, ribosomal protein L19 was identified as a novel over-expressed tumor antigen.

Research Products

• [Journal Article] Identification of ribosomal protein L19 as a novel tumor antigen recognized by autologous cytotoxic T lymphocytes in lung adenocarcinoma. (2010)
  • Author(s): Kuroda, K.・Takenoyama, M.・Baba, T.・Shigematsu, Y.・Shiota, H.・Ichiki, Y.・Yasuda, M.・Uramoto, H.・Hanagiri, T. :Yasumoto, K.
  • Journal Title: Cancer Sci 101 Pages: 46-53
  • Peer Reviewed
• [Journal Article] Clinical significance of cancer/testis antigens expression in patients with non-small cell lung cancer. (2010)
  • Author(s): Shigematsu, Y.・Hanagiri, T.・Shiota, H.・Kuroda, K.・Baba, T.・Mizukami, M.・So, T.・Ichiki, Y.・Yasuda, M.・So, T.・Takenoyama, M.・Yasumoto, K.
  • Journal Title: Lung Cancer 68 Pages: 105-110
  • Peer Reviewed
• [Journal Article] Current status and perspectives on immunotherapy for lung cancer. (2009)
  • Author(s): Hanagiri, T.・Takenoyama, M.・Yasumoto, K.
  • Journal Title: Curr Res in Cancer 3 Pages: 75-87
• [Journal Article] 肺癌の免疫療法の現況と展望. (2009)
  • Author(s): 花桐武志・竹之山光広・安元公正
  • Journal Title: 呼吸器科 15(2) Pages: 132-138
• [Journal Article] Clinical significance of HLA class I alleles on postoperative prognosis of lung cancer patients in Japan. (2009)
  • Author(s): Nagata, Y.・Hanagiri, T.・Mizukami, M.・Kuroda, K.・Shigematsu, Y.・Baba, T.・Ichiki, Y.・Yasuda, M.・So, T.・Takenoyama, M.・Sugio, K.・Nagashima, A.・Yasumoto, K.
  • Journal Title: Lung Cancer 65(1) Pages: 91-97
  • Peer Reviewed
• [Journal Article] Malignant mesothelioma-associated antigens recognized by tumor-infiltrating B cells and the clinical significance of the antibody titers. (2009)
  • Author(s): Shigematsu, Y.・Hanagiri, T.・Kuroda, K.・Baba, T.・Mizukami, M.・Ichiki, Y.・Yasuda, M.・Takenoyama, M.・Sugio, K.・Yasumoto, K.
  • Journal Title: Cancer Sci 100(7) Pages: 1326-1334
  • Peer Reviewed
• [Journal Article] Lung cancer-associated tumor antigens and the present status of immunotherapy against non-small-cell lung cancer. (2009)
  • Author(s): Yasumoto, K.・Hanagiri, T.・Takenoyama, M.
  • Journal Title: Gen Thorac Cardiovasc Surg 57(9) Pages: 449-457
  • Peer Reviewed
• [Journal Article] 癌免疫療法-最近の話題から- (2009)
  • Author(s): 花桐武志・竹之山光広・安元公正
  • Journal Title: Biotherapy 23(6) Pages: 401-407
• [Journal Article] Lack and restoration of sensitivity of lung cancer cells to cellular attack with special reference to expression of human leukocyte antigen class I and/or major histocompatibility complex class I chain related molecules A/B. (2007)
  • Author(s): Baba, T.・Hanagiri, T.・Ichiki, Y.・Kuroda, K.・Shigematsu, Y.・Mizukami, M.・Sugaya, M.・Takenoyama, M.・Sugio, K.・Yasumoto, K.
  • Journal Title: Cancer Sci 98(11) Pages: 1795-1802
  • Peer Reviewed
• [Journal Article] Antitumor Effect of Antibody against a SEREX-Defined Antigen (UOEH-LC-1) on Lung Cancer Xenotransplanted into Severe Combined Immunodeficiency Mice. (2007)
  • Author(s): Mizukami, M.・Hanagiri, T.・Yasuda, M.・Kuroda, K.・Shigematsu, Y.・Baba, T.・Fukuyama, T.・Nagata, Y.・So, T.・Ichiki, Y.・Sugaya, M.・So, T.・Takenoyama, M.・Sugio, K.・Yasumoto, K.
  • Journal Title: Cancer Res 67(17) Pages: 8351-8357
  • Peer Reviewed
• [Journal Article] Cytokine production of lung cancer cell lines: Correlation between their production and the inflammatory/ immunological responses both in vivo and in vitro. (2007)
  • Author(s): Fukuyama, T.・Ichiki, Y.・Yamada, S.・Shigematsu, Y.・Baba, T.・Nagata, Y.・Mizukami, M.・Sugaya, M.・Takenoyama, M.・Hanagiri, T.・Sugio, K.・Yasumoto, K.
  • Journal Title: Cancer Sci 98(7) Pages: 1048-1054
  • Peer Reviewed
• [Journal Article] 肺癌に対する免疫応答と免疫療法. (2007)
  • Author(s): 竹之山光広・花桐武志・安元公正
  • Journal Title: 細胞 39(6) Pages: 260-263
• [Presentation] 新規腫瘍抗原Ribosomal protein L19の発現と機能の解明 (2009)
  • Author(s): 黒田耕志・竹之山光広・宗知子・塩田広宣・馬場哲郎・重松義紀・永田好香・宗哲哉・市来嘉伸・安田学・小野憲司・浦本秀隆・花桐武志・安元公正
  • Organizer: 第63回日本呼吸器学会・日本結核病学会九州支部秋季学術講演会
  • Place of Presentation: 北九州
  • Year and Date: 20091126-20091127
• [Presentation] T細胞受容体移入γδT細胞を用いた特異的癌免疫療法の開発 (2009)
  • Author(s): 重松義紀・塩田広宣・黒田耕志・馬場哲郎・宗哲哉・小野憲司・浦本秀隆・宗知子・竹之山光広・花桐武志・安元公正
  • Organizer: 第63回日本呼吸器学会・日本結核病学会九州支部秋季学術講演会
  • Place of Presentation: 北九州
  • Year and Date: 20091126-20091127
• [Presentation] 肺癌における細胞障害性T細胞が認識する腫瘍抗原の同定 (2009)
  • Author(s): 竹之山光広・花桐武志・宗知子・安田学・市来嘉伸・宗哲哉・永田好香・馬場哲郎・重松義紀・黒田耕志・小野憲司・浦本秀隆・安元公正
  • Organizer: 第62回日本胸部外科学会定期学術集会
  • Place of Presentation: 横浜
  • Year and Date: 20091011-20091114
• [Presentation] The identification of tumor antigens associated with asbestos-related lung cancer. (2009)
  • Author(s): Hanagiri, T.・Yasuda, M.・Kuroda, K.・Shigematsu, Y.・Baba, T.・So, T.・Ono, K.・Uramoto, H.・So, T.・Takenoyama, M.・Yasumoto, K.
  • Organizer: 13th World Conference on Lung Cancer
  • Place of Presentation: San Francisco, USA
  • Year and Date: 20090731-20090804
• [Presentation] T細胞受容体移入γδT細胞を用いた特異的癌免疫療法の開発. (2009)
  • Author(s): 重松義紀・塩田広宣・黒田耕志・馬場哲郎・宗哲哉・市来嘉伸・小野憲司・浦本秀隆・宗知子・竹之山光広・花桐武志・安元公正
  • Organizer: 第13回日本がん免疫学会総会
  • Place of Presentation: 北九州
  • Year and Date: 20090624-20090625
• [Presentation] HLA発現異常を有する肺癌に対する腫瘍特異的Tリンパ球の解析. (2009)
  • Author(s): 黒田耕志・竹之山光広・馬場哲郎・重松義紀・宗哲哉・市来嘉伸・小野憲司・安田学・浦本秀隆・宗知子・花桐武志・安元公正
  • Organizer: 第13回日本がん免疫学会総会
  • Place of Presentation: 北九州
  • Year and Date: 20090624-20090625
• [Presentation] 石綿関連肺癌に対する液性免疫応答の解析. (2009)
  • Author(s): 安田学・花桐武志・黒田耕志・鬼塚貴光・重松義紀・馬場哲郎・永田好香・宗哲哉・小野憲司・浦本秀隆・宗知子・竹之山光広・安元公正
  • Organizer: 第13回日本がん免疫学会総会
  • Place of Presentation: 北九州
  • Year and Date: 20090624-20090625
• [Presentation] HLA classI発現陰性肺癌細胞に対する腫瘍特異的細胞性免疫応答の解析. (2009)
  • Author(s): 黒田耕志・馬場哲郎・竹之山光広・重松義紀・宗哲哉・市来嘉伸・安田学・宗知子・花桐武志・杉尾賢二・安元公正
  • Organizer: 第30回癌免疫外科研究会
  • Place of Presentation: 久留米
  • Year and Date: 20090521-20090522
• [Presentation] 非小細胞肺癌におけるHLA発現と免疫応答の解析. (2009)
  • Author(s): 黒田耕志・塩田広宣・重松義紀・馬場哲郎・水上真紀子・市来嘉伸・安田学・大賀丈史・竹之山光広・花桐武志・杉尾賢二・安元公正
  • Organizer: 第26回日本呼吸器外科学会総会
  • Place of Presentation: 北九州
  • Year and Date: 20090514-20090515
• [Presentation] 肺癌に対する新規抗体療法の開発. (2009)
  • Author(s): 安田学・花桐武志・水上真紀子・塩田広宣・黒田耕志・重松義紀・馬場哲郎・永田好香・宗哲哉・市来嘉伸・菅谷将一・浦本秀隆・宗知子・大賀丈史・竹之山光広・杉尾賢二・安元公正
  • Organizer: 第26回日本呼吸器外科学会総会
  • Place of Presentation: 北九州
  • Year and Date: 20090514-20090515
• [Presentation] 腫瘍抗原特異的T細胞受容体(TCR)遺伝子移入による抗腫瘍エフェクター細胞の誘導(第2報) (2009)
  • Author(s): 竹之山光広・重松義紀・塩田広宣・黒田耕志・馬場哲郎・市来嘉伸・花桐武志・安元公正
  • Organizer: 第62回日本呼吸器学会・日本結核病学会九州支部春季学術講演会
  • Place of Presentation: 那覇
  • Year and Date: 2009-05-23
• [Presentation] 肺癌におけるHLA classI分子の発現と細胞性免疫応答. (2008)
  • Author(s): 黒田耕志・竹之山光広・馬場哲郎・塩田広宣・重松義紀・水上真紀子・市来嘉伸・花桐武志・杉尾賢二・安元公正
  • Organizer: 第21回日本バイオセラピィ学会学術集会総会
  • Place of Presentation: 東京
  • Year and Date: 20081118-20081119
• [Presentation] 肺癌症例における腫瘍特異的CD4+T細胞の免疫応答. (2008)
  • Author(s): 黒田耕志・竹之山光広・馬場哲郎・塩田広宣・重松義紀・永田好香・水上真紀子・市来嘉伸・安田学・花桐武志・杉尾賢二・安元公正
  • Organizer: 第49回日本肺癌学会総会
  • Place of Presentation: 北九州
  • Year and Date: 20081114-20081115
• [Presentation] HLA classI発現を欠失した肺癌症例での新規癌関連抗原の同定. (2008)
  • Author(s): 馬場哲郎・塩田広宣・黒田耕志・重松義紀・水上真紀子・市来嘉伸・竹之山光広・花桐武志・杉尾賢二・安元公正
  • Organizer: 第49回日本肺癌学会総会
  • Place of Presentation: 北九州
  • Year and Date: 20081114-20081115
• [Presentation] 腫瘍抗原特異的T細胞受容体(TCR)遺伝子移入による抗腫瘍エフェクター細胞の誘導. (2008)
  • Author(s): 竹之山光広・塩田広宣・黒田耕志・重松義紀・馬場哲郎・水上真紀子・市来嘉伸・花桐武志・杉尾賢二・安元公正
  • Organizer: 第61回日本呼吸器学会・日本結核病学会九州支部秋季学術講演会
  • Place of Presentation: 宜野湾
  • Year and Date: 20081106-20081107
• [Presentation] 肺腺癌におけるctlの認識する新規腫瘍抗原Ribosomal Protein L19の同定. (2008)
  • Author(s): 黒田耕志・竹之山光広・塩田広宣・重松義紀・馬場哲郎・水上真紀子・市来嘉伸・花桐武志・杉尾賢二・安元公正
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 20081028-20081030
• [Presentation] Identification of human ribosomal protein L19 as a novel overexpressed tumour antigen recognized by autologous CTL in human lung adenocarcinoma. (2008)
  • Author(s): Kuroda, K.・Takenoyama, M.・Baba, T.・Shiota, H.・Shigematsu, Y.・Mizukami, M.・Ichiki, Y.・Yasuda, M.・Hanagiri, T.・Sugio, K.・Yasumoto, K.
  • Organizer: 2008 World Cancer Congress
  • Place of Presentation: Geneva, Switzerland
  • Year and Date: 20080827-20080831
• [Presentation] T細胞受容体移入細胞を用いた抗腫瘍エフェクターの作成. (2008)
  • Author(s): 塩田広宣・黒田耕志・重松義紀・馬場哲郎・水上真紀子・市来嘉伸・竹之山光広・花桐武志・杉尾賢二・安元公正
  • Organizer: 第29回癌免疫外科研究会
  • Place of Presentation: 東京
  • Year and Date: 20080619-20080620
• [Presentation] 細胞障害性Tリンパ球が認識する過剰発現肺癌抗原Ribosomal protein L19の同定と発現解析. (2008)
  • Author(s): 黒田耕志・竹之山光広・宗知子・塩田広宣・重松義紀・馬場哲郎・永田好香・水上真紀子・市来嘉伸・安田学・野添忠浩・花桐武志・杉尾賢二・安元公正
  • Organizer: 第108回日本外科学会定期学術集会
  • Place of Presentation: 長崎
  • Year and Date: 20080515-20080517
• [Presentation] 癌精巣抗原KK-LC-1 mRNAを移入したPHA blastを用いた新たなreverse immnologyhou法の確立 (2007)
  • Author(s): 竹之山光広・黒田耕志・塩田広宣・馬場哲郎・重松義紀・永田好香・水上真紀子・市来嘉伸・安田学・野添忠浩・花桐武志・杉尾賢二・安元公正
  • Organizer: 第60回日本胸部外科学会定期学術集会
  • Place of Presentation: 仙台
  • Year and Date: 20071017-20071020