2009 Fiscal Year Final Research Report
Skin-derived stem cells transplanted into cerebral ischemia and injured hypoglossal nerve in mice
| Project/Area Number |
19591664
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | The University of Tokyo |
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Principal Investigator |
TAKAI Keisuke The University of Tokyo, 医学部附属病院, 助教 (70376424)
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| Co-Investigator(Kenkyū-buntansha) |
SAITO Nobuhito 東京大学, 医学部附属病院, 教授 (60262002)
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| Co-Investigator(Renkei-kenkyūsha) |
OKOUTI Hitoshi 国立国際医療研究センター研究所, 細胞組織再生医学研究部, 部長 (30185235)
KIRINO Takaaki 国立国際医療研究センター, 理事長 (90126045)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 移植 / 再生医学 |
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| Research Abstract |
Skin-derived stem cells transplanted into cerebral ischemia in mice had survived, however, they didn't migrated into all the ischemic area and didn't contribute the recovery from ischemic damage. These cells transplanted into injured hypoglossal nerve in mice also had survived and differentiated into Schwann-like cells. These Schwann-like cells didn't contribute axonal regeneration and the recovery from myelin-deficient peripheral nerve. These cells transplanted into injured sciatic nerve in myelin-deficient mice didn't survived. Skin-derived stem cells survive and differentiate under limited condition.
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