Analysis of mechanism of intractable pain with primate model of thalamic pain and development of new treatment

2008 Fiscal Year Final Research Report

• Project/Area Number: 19591673
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: Osaka University
• Principal Investigator: SAITOH Youichi Osaka University, 医学系研究科, 准教授 (20252661)
• Co-Investigator(Kenkyū-buntansha): KISHIMA Haruhiko 大阪大学, 医学系研究科, 助教 (10332743) ; OSHINO Satoru 大阪大学, 医学系研究科, 助教 (40403050)
• Co-Investigator(Renkei-kenkyūsha): YOSHIMINE Toshiki 大阪大学, 医学系研究科, 教授 (00201046) ; HIRATA Masayuki 大阪大学, 医学系研究科, 助教 (30372626) ; HATAZAWA Jyun 大阪大学, 医学系研究科, 教授 (70198745)
• Project Period (FY): 2007 – 2008
• Keywords: 視床痛 / 難治性疼痛 / 脳卒中後疼痛 / 霊長類 / 中枢性疼痛 / アロジニア / アカゲザル

Research Abstract

脳卒中後疼痛のメカニズム解明のため、動物視床痛モデル作成を試みたが、結果としてはラット、霊長類ともに作成ができなかった。脳卒中後疼痛患者の視床、被殻病変でのMRIのDiffusion tensor imageでは患側の描出率と経頭蓋磁気刺激療法による一次運動野刺激による除痛率との相関を検討したところ、運動線維および感覚線維の両者の描出率と相関が得られたが、感覚線維の描出率とより相関が得られた。この結果は病巣の主座が被殻であっても感覚中継核である視床腹外側核およびその線維連絡の保持が経頭蓋磁気刺激による一次運動野刺激による除痛効果とよく相関することが示されたと解釈された

Research Products

• [Journal Article] Electrical stimulation of primary motor cortex within he cenral sulcus for intractable neuropathic pain (2008)
  • Author(s): Hosomi K, Saitoh Y, Kishima H, Oshino S, Hirata M, Tani N, Shimokawa T, Yoshimine T
  • Journal Title: Clin Neurophysiol 119 Pages: 993-1001
  • Peer Reviewed
• [Journal Article] MRI-based correction for partial-voe effect improves detectability of intractable epileptogenic foci on I-123 iomazenil brain SPECT images (2008)
  • Author(s): Kato H, Shimosegawa E, Oku, N, Kitagawa K, Kishima H, Saitoh Y, Kato A, Yoshimine T
  • Journal Title: J Nucl Med 49 Pages: 383-389
  • Peer Reviewed
• [Journal Article] Mechanistic analysis of motor cortex stimulation for phantom limb pain (2008)
  • Author(s): Yanagisawa T, Saitoh Y, Hirata M, Yamashita O, Kamitani Y, Oshino S, Kishima H, Tani N, Hosomi K, Goto T, Satou M, Kakigi R, Yoshimine T
  • Journal Title: Pain Res 23 Pages: 27-34
  • Peer Reviewed
• [Journal Article] Mirror visual fedback alleviates deafferentation pain, depending on qualitative aspects of the pain : a preliminary report (2008)
  • Author(s): Sumitani M, Miyauchi S, McCabe CS, Shibata M, Maeda L, Saitoh Y, Tashiro T, Mashimo T
  • Journal Title: Rheumatology 47 Pages: 1038-1043
  • Peer Reviewed
• [Journal Article] Evoked magnetic fields following noxious laser stimulation of the thigh in humans (2008)
  • Author(s): Nakata H, Tamura Y, Sakamoto K, Akatsuka K, Hirai M, Inui K, Hoshiyama M, Saitoh Y, Yamamoto T, Katayama Y, Kakigi R
  • Journal Title: Neuroimage 42 Pages: 858-868
  • Peer Reviewed
• [Journal Article] Diffusion tensor fiber tracking in patients with central post-stroke pain; Correation with efficacy of repetitive transcranial magnetic stimulation (2008)
  • Author(s): Goto T, Saitoh Y, Hashimoto N, Hirata M, Kishima H, Oshino S, Naoki Tani, Hosomi K, Kakigi R, Yoshimine T
  • Journal Title: Pain 140 Pages: 509-518
  • Peer Reviewed
• [Journal Article] Ipsilateral motor-reated hyperactivity in patients with cerebral occlusive vascular disease (2008)
  • Author(s): Oshino S, Kato A, Hirata M, Kishima H, Saitoh Y, , Yoshimine T
  • Journal Title: Stroke 39 Pages: 2769-2775
  • Peer Reviewed
• [Journal Article] Mechanistic analysis of motor cortex stimulation for phantom limb pain (2008)
  • Author(s): Yanagisawa T, Saitoh Y, Hirata M, Yamasita O, Kamitani Y, Oshino S, Kishima H, Tani N, Hosomi K, Goto T, Satou M, Kakigi R, Yoshimine T
  • Journal Title: pain research 23 Pages: 27-34
  • Peer Reviewed
• [Journal Article] Kasayama S (2007) Reduced epinene reserve in response to insulin-induced hypoglycemia in patients with pituitary adenoma (2007)
  • Author(s): Morita S, Otsuki M, Izumi M, Asanuma N, Izumoto S, Saitoh Y, Yoshimine T
  • Journal Title: Eur J Endocrinol 157 Pages: 265-270
  • Peer Reviewed
• [Journal Article] Reduction of intractable deafferentation pain due to spinal cord orl lesion by high-frequency (2007)
  • Author(s): Saitoh Y, Hirayama A, Kishima H, Shimokawa T, Oshino S, Hirata M, Tani N, Kato A, Yoshimine T
  • Journal Title: repetitive transcranial magnetic stimulation of the primary motor cortex J Neurosurg 107 Pages: 555-559
  • Peer Reviewed
• [Journal Article] Motor cortex stimulation activates posterior insula and thalamus In deafferentation pain patients JNeurosurg (2007)
  • Author(s): Kishima H, Saitoh Y, OsakiY, Nishimura H, Kato A, Hatazawa J, Yoshimine T
  • Journal Title: 107 Pages: 43-48
  • Peer Reviewed
• [Journal Article] Motor cortex stimulation for L-dopa resistant akinesia (2007)
  • Author(s): Tani N, Saitoh Y, Kishima H, Oshino S, Hatazawa J, Hashikawa K, Yoshimine T
  • Journal Title: Mov Disord 22 Pages: 1645-1648
  • Peer Reviewed
• [Journal Article] Efficaof spinal cord stimulation on post-stroke pain (2007)
  • Author(s): Saitoh Y, Sumitani M, Oshino S, Kishima H, Tani N, Hirata M, Hosomi K, Mashimo T, Yoshimine T
  • Journal Title: Pain Research 22 Pages: 123-126
  • Peer Reviewed
• [Journal Article] Examination of cortical reorganization limb pain by transcranial magnetic stimulation (2007)
  • Author(s): Yanagisawa T, Saitoh Y, Oshino S, Kishima H, Hirata M, Tani N, Sumitani M, Kato A, Yoshimine T
  • Journal Title: magnetic encphalogphy and seory evoked potential. Pain Research 22 Pages: 143-148
  • Peer Reviewed
• [Presentation] Neural decoding using gyral and intrasulcal electrocorticograms (2008)
  • Author(s): Yanagisawa T
  • Organizer: Society for neuroscience meeting 2008
  • Place of Presentation: Washington, D.C., USA
  • Year and Date: 20081115-19
• [Presentation] 難治性神経因性疼痛に対する反復経頭蓋磁気刺激療法 (2008)
  • Author(s): 細見晃一
  • Organizer: 第38回日本臨床神経生理学会
  • Place of Presentation: 神戸
  • Year and Date: 20081112-14
• [Presentation] 脳磁図、皮質電位、ファイバートラッキング、経頭蓋磁気刺激を用いた術前術中視覚機能評価 (2008)
  • Author(s): 平田雅之
  • Organizer: 第38回日本臨床神経生理学会
  • Place of Presentation: 神戸
  • Year and Date: 20081112-14
• [Presentation] 機能的脳疾患に対する中枢神経刺激療法 (2008)
  • Author(s): 齋藤洋一
  • Organizer: 現状と展望、第67回日本脳神経外科学会
  • Place of Presentation: 盛岡
  • Year and Date: 20081001-03
• [Presentation] 皮質脳波を用いたBrain machine interfaceによるリアルタイムロボット制御 (2008)
  • Author(s): 平田雅之
  • Organizer: 現状と今後の展望
  • Place of Presentation: 盛岡
  • Year and Date: 20081001-03
• [Presentation] 中心溝内皮質脳波を用いたBrain machine interfaceによる運動機能再建 (2008)
  • Author(s): 柳澤琢史
  • Organizer: 第18回日本神経回路学会
  • Place of Presentation: つくば市
  • Year and Date: 20080924-26
• [Presentation] 経鼻孔的下垂体腫瘍摘出術における手術道具の工夫 (2008)
  • Author(s): 齋藤洋一
  • Organizer: 第18回日本間脳下垂体腫瘍学会
  • Place of Presentation: 福井
  • Year and Date: 20080229-0301
• [Presentation] ラトケのう胞の長期治療成績と長期自然経過 (2008)
  • Author(s): 泉本修一
  • Organizer: 第18回日本間脳下垂体腫瘍学会
  • Place of Presentation: 福井
  • Year and Date: 20080229-0301
• [Presentation] 側頭葉てんかんに対する手術前後の社会生活状況の変化 (2008)
  • Author(s): 齋藤洋一
  • Organizer: 第47回日本定位・機能神経外科学会
  • Place of Presentation: 浜松
  • Year and Date: 20080125-26
• [Presentation] 中枢性疼痛に対する反復的経頭蓋磁気刺激療法 (2008)
  • Author(s): 齋藤洋一
  • Organizer: 第47回日本定位・機能神経外科学会
  • Place of Presentation: 浜松
  • Year and Date: 20080125-26
• [Presentation] 中枢性疼痛に対する硬膜下一次運動野刺激療法 (2008)
  • Author(s): 細見晃一
  • Organizer: 第47回日本定位・機能神経外科学科依
  • Place of Presentation: 浜松
  • Year and Date: 20080125-26
• [Presentation] 運動異常症に対する大脳皮質刺激療法の可能性 (2008)
  • Author(s): 貴島晴彦
  • Organizer: 第47回日本定位・機能神経外科学会
  • Place of Presentation: 浜松
  • Year and Date: 20080125-26
• [Presentation] Surgical treatment for intractable epilepsy with cortical dysplasia (2008)
  • Author(s): Kishima H
  • Organizer: 2^<nd> ASIAN EPILEPSY SURGERY CONGRESS
  • Place of Presentation: Shijiazhuang, China
  • Year and Date: 2008-10-25
• [Presentation] Comparison between preoperative I-123 iomazenil SPECT and FDG-PET in epilepsy surgery (2008)
  • Author(s): Hosomi K
  • Organizer: 2^<nd>ASIAN EPILEPSY SURGERY CONGRESS
  • Place of Presentation: Shi jiazhuang, China
  • Year and Date: 2008-10-25
• [Presentation] てんかん外科のための皮質電気刺激と皮質脳波律動変化を併用した脳機能マッピング (2008)
  • Author(s): 平田雅之
  • Organizer: 第42回日本てんかん学会
  • Place of Presentation: 東京
  • Year and Date: 2008-10-19
• [Presentation] 脳表脳波計測に基づく運動制御の実時間復号化 (2008)
  • Author(s): 平田雅之
  • Organizer: 第23回生体・生理工学シンポジウム
  • Place of Presentation: 名古屋
  • Year and Date: 2008-09-28
• [Presentation] Ipsilateral motor-related hyperactivity in patients with cerebral occlusive vascular disease (2008)
  • Author(s): Oshino S
  • Organizer: International Conference on Biomagnetism(Biomag)
  • Place of Presentation: Sapporo, Japan
  • Year and Date: 2008-08-25
• [Presentation] Functional mapping by transcranial magnetic stimulation (TMS) on motor cortex of the patiewith deafferentation pain (2008)
  • Author(s): Yanagisawa T
  • Organizer: 16thInternational Conference on Biomagnetism(Biomag)
  • Place of Presentation: Sapporo, Japan
  • Year and Date: 2008-08-25
• [Presentation] Dissociation in accessing external and internal space representations in patients with CRPS and deafferentation pain (2008)
  • Author(s): Sumitani M
  • Organizer: 12th World Congress of Pain
  • Place of Presentation: Glasgo UK
  • Year and Date: 2008-08-19
• [Presentation] Eficacy of spinal cord stimulation in post-stroke pain (2008)
  • Author(s): Mohamed A
  • Organizer: 7th Asian Congress of Neurological Surgeons
  • Place of Presentation: Bei jin, China
  • Year and Date: 2008-06-22
• [Presentation] 臨床神経生理学分野における医工連携の重要性 (2008)
  • Author(s): 平田雅之
  • Organizer: 第23回日本生体磁気学会
  • Place of Presentation: 東京
  • Year and Date: 2008-06-13
• [Presentation] 脊髄刺激療法の適応について 脳神経外科の立場から (2008)
  • Author(s): 齋藤洋一
  • Organizer: 第22回日本ニューロモデュレーション学会
  • Place of Presentation: 東京
  • Year and Date: 2008-05-17
• [Presentation] Repetitive transcranial magnetic stimulation therapy for intractable neuropathic paimovement disorder (2008)
  • Author(s): Saitoh Y
  • Organizer: Korean Neuromodulation Society Meeting
  • Place of Presentation: Seoul, South Korea
  • Year and Date: 2008-04-05
• [Presentation] Electrical stimulation of primary motor cortex within the central sulcus for intractable neuropathic pain (2008)
  • Author(s): Saitoh Y
  • Organizer: Seoul, South Korea
  • Place of Presentation: Seoul, South Korea
  • Year and Date: 2008-04-04
• [Presentation] 側頭葉てんかんに対する手術前後の社会生活状況の変化 (2008)
  • Author(s): 貴島晴彦
  • Organizer: 第31回日本てんかん外科学会
  • Place of Presentation: 浜松
  • Year and Date: 2008-01-24
• [Presentation] 開口合成脳磁図を用いた言語優位半球、言語機能局在の術前評価 : 侵襲的検査法との比較検証 (2008)
  • Author(s): 平田雅之
  • Organizer: 第31回日本てんかん外科学会
  • Place of Presentation: 浜松
  • Year and Date: 2008-01-24
• [Presentation] Stimulation of primary motorcortex for intractable neuropathic pain (2008)
  • Author(s): Saitoh Y
  • Organizer: 浜松医科大学COE国際シンポジウム
  • Place of Presentation: Hamamatsu, Japan
  • Year and Date: 2008-01-23
• [Presentation] Primary motor cortex stimulation for intractable neuropathic pain (2007)
  • Author(s): Saitoh Y
  • Organizer: International Neuromodulation Society
  • Place of Presentation: Acapulco, Mexico
  • Year and Date: 20071208-12
• [Presentation] Neural decoding of human upper limb movements by gyral and intrasulcal electrocorticogram (2007)
  • Author(s): Yanagisawa T
  • Organizer: NIPS workshop 'Large scale brain dynamics
  • Place of Presentation: Whistler, Canada
  • Year and Date: 20071207-08
• [Presentation] Therapy with navigation-guided repetitive transcranial magnetic stimulation for intractable pain and movement disorder (2007)
  • Author(s): Saitoh Y
  • Organizer: World Federation of Neurosurgical Societies, 13^<th> Interim Meeting/ The 12^<th> Asian-Australasian Congress of Neurological Surgeons
  • Place of Presentation: Nagoya, Japan
  • Year and Date: 20071118-22
• [Presentation] 先端巨大症の術後長期成績からみた治療戦略の検討 (2007)
  • Author(s): 齋藤洋一
  • Organizer: 第66回日本脳神経外科学会
  • Place of Presentation: 東京
  • Year and Date: 20071003-05
• [Presentation] 日本における脊髄刺激療法の現状 (2007)
  • Author(s): 齋藤洋一
  • Organizer: 第66回日本脳神経外科学会
  • Place of Presentation: 東京
  • Year and Date: 20071003-05
• [Presentation] Functional restoration by brain computer interface (BCI) using gyral and sulcal electrocorticogram (ECoG) (2007)
  • Author(s): Yanagiswa T
  • Organizer: 2^<nd> Congress of International Society of Reconstructive Neurosurgery, 5th Scientific Meeting of the WFNS Neurorehabilitation
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 20070913-16
• [Presentation] 大脳一次運動野刺激による大脳皮質再構築の検討 (2007)
  • Author(s): 齋藤洋一
  • Organizer: 第30回日本神経科学会
  • Place of Presentation: 横浜
  • Year and Date: 20070910-12
• [Presentation] Primary motor cortex stimulation for intractable neuropathic pain (2007)
  • Author(s): Saitoh Y
  • Organizer: 13th European Congress of Neurosurgery
  • Place of Presentation: Glasgo, UK
  • Year and Date: 20070902-07
• [Presentation] Less invasive selectiveamygdala-hippocampectomy using navigation system via inferior temporal gyrus (2007)
  • Author(s): Kishima H
  • Organizer: the 27th International Epilepsy Congress
  • Place of Presentation: Singapore, Singapore
  • Year and Date: 20070708-12
• [Presentation] Successful epilepsy surgery for focal cortical dysplasia in the paracentral area (2007)
  • Author(s): Kishima H
  • Organizer: 1^<st> Congress of the Asian Epilepsy Surgery
  • Place of Presentation: Seoul, South Korea
  • Year and Date: 20070601-02
• [Presentation] Long-term results of primary motor cortex stimulation for intractable deafferentation pain (2007)
  • Author(s): Saitoh Y
  • Organizer: Primary motor cortex stimulation for intractable neuropathic pain. 6^<th>Congress of Asian Society for Stereotactic, Functional and Computer Assisted Neurosurgery
  • Place of Presentation: Fujiyoshida, Japan
  • Year and Date: 20070522-24
• [Presentation] Functional brain mapping and restoration using event-related oscillatory changes. 6^<th> Congress of Asian Society for Stereotactic (2007)
  • Author(s): Hirata M
  • Organizer: Functional and Computer Assisted Neurosurgery
  • Place of Presentation: Fujiyoshida, Japan
  • Year and Date: 20070522-24
• [Presentation] Neurosurgical treatment forintractable pain after spinal root avulsion (2007)
  • Author(s): Oshino S
  • Organizer: 6^<th> Congress of Asian Society for Stereotactic, Functional and Computer Assisted Neurosurgery
  • Place of Presentation: Fujiyoshida, Japan
  • Year and Date: 20070522-24
• [Presentation] Cortical stimulation for hypokinetic movement disorders ; Clinical experience of repetitive transcranial magnetic stimulation(rTMS) and chronic motor cortex stimulation (MCS) (2007)
  • Author(s): Tani N
  • Organizer: 6^<th> Congress ofAsian Society for Stereotactic, Functional and Computer Assisted Neurosurgery
  • Place of Presentation: Fujiyoshida, Japan
  • Year and Date: 20070522-24
• [Presentation] Brain modulation with SCS for intractable deafferentation pai6th Congress of Asian Society for Stereotactic (2007)
  • Author(s): Kishima H
  • Organizer: Functional and Computer Assisted Neurosurgery
  • Place of Presentation: Fujiyoshida, Japan
  • Year and Date: 20070522-24
• [Presentation] Brain modulation with MCS & SCS for intractable deafferentation pain ; PET analysis (2007)
  • Author(s): Kishima H
  • Organizer: Brain 2007
  • Place of Presentation: Osaka, Japan
  • Year and Date: 20070520-24
• [Presentation] 脊髄・末梢性難治性疼痛の治療 (2007)
  • Author(s): 齋藤洋一
  • Organizer: 第27回日本脳神経外科コングレス
  • Place of Presentation: 仙台
  • Year and Date: 20070518-20
• [Presentation] GH産生下垂体腺腫に対するOctreotide(LAR)術前投与 (2007)
  • Author(s): 齋藤洋一
  • Organizer: 第17回日本間脳下垂体腫瘍学会
  • Place of Presentation: 山形
  • Year and Date: 20070223-24
• [Presentation] 尿崩症で発症し、経過中に内頚動脈の狭小化を認めた肥厚性硬膜炎の一例 (2007)
  • Author(s): 有田英之
  • Organizer: 第17回日本間脳下垂体腫瘍学会
  • Place of Presentation: 山形
  • Year and Date: 20070223-24
• [Presentation] 脳卒中後疼痛に対する治療戦略 : 大脳運動野刺激療法と脊髄刺激療法の長期予後 (2007)
  • Author(s): 齋藤洋一
  • Organizer: 第17回日本間脳下垂体腫瘍学
  • Place of Presentation: 山形
  • Year and Date: 20070223-24
• [Presentation] Cushing病の診断におけるvenous samplingの意義と問題点 (2007)
  • Author(s): 押野悟
  • Organizer: 第17回日本間脳下垂体腫瘍学
  • Place of Presentation: 山形
  • Year and Date: 20070223-24
• [Presentation] 脊髄由来の難治性疼痛に対する脳神経外科的治療 (2007)
  • Author(s): 押野悟
  • Organizer: 第46回日本定位・機能神経外科学会
  • Place of Presentation: 福岡
  • Year and Date: 20070127-28
• [Presentation] 脳卒中後疼痛患者におけるtractographyとrTMSの治療効果 (2007)
  • Author(s): 後藤哲
  • Organizer: 第46回日本定位・機能神経外科学会
  • Place of Presentation: 福岡
  • Year and Date: 20070127-28
• [Presentation] 痙性斜頚に対する反復的経頭蓋磁気刺激療法 (2007)
  • Author(s): 谷直樹
  • Organizer: 第46回日本定位・機能神経外科学会
  • Place of Presentation: 福岡
  • Year and Date: 20070127-28
• [Presentation] Alteration in motor magnetic field in patients with cerebral vascular occlusive disease (2007)
  • Author(s): Oshino S
  • Organizer: ISCAM (First Conference of InternationalSociety for the Advancement of Clinical Magnetoencephalography)
  • Place of Presentation: Sendai, Japan
  • Year and Date: 2007-08-29
• [Book] Nova Science Publishers, Inc. Hauppauge NY(in press) (2009)
  • Author(s): Saitoh Y, Hosomi K
  • Publisher: Capter 2. From localization to surgical implantation. In Textbook of therapeutic cortical stimulation Ed : Sergio Canavero
• [Book] アルタ出版 (2007)
  • Author(s): 齋藤洋一
  • Total Pages: 236
  • Publisher: 痛みをとる
• [Patent(Industrial Property Rights)] 経頭蓋磁気刺激用頭部固定具及び経頭蓋磁気刺激装置 (2007)
  • Inventor(s): 齋藤洋一
  • Industrial Property Rights Holder: 齋藤洋一
  • Industrial Property Number: PCT/JP2007/058411
  • Filing Date: 2007-04-18