Expression of SOX4 gene and its roles in medulloblastoma

2009 Fiscal Year Final Research Report

• Project/Area Number: 19591686
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: Kyushu University
• Principal Investigator: SHONO Tadahisa Kyushu University, 医学研究院, 准教授 (00346793)
• Co-Investigator(Kenkyū-buntansha): YOSHIMOTO Koji 九州大学, 大学病院, 講師 (70444784) ; MATSUMOTO Kenichi 九州大学, 大学病院, 研究員 (80423581) ; AMANO Toshiyuki 九州大学, 大学病院, 助教 (70448413)
• Project Period (FY): 2007 – 2009
• Keywords: Sox4 / 髄芽種 / グリオーマ / アポトーシス / 神経分化

Research Abstract

We analyzed the expression of Sox4 mRNA in various brain tumor samples obtained by surgical resection or tumor cell lines using real-time PCR analysis. We found that the expression levels of Sox4 mRNA in medulloblastomas are especially increased among these brain tumors. When we transfer Sox4 gene into malignant glioma cell lines, the cell growth was strongly enhanced. Conversely, when we transfer Sox4 gene into medulloblastoma cell lines, there was no significant change in cell growth.

Research Products

• [Journal Article] Effect of tumor removal on tinnitus in patients with vestibular schwannoma. (2010)
  • Author(s): Kameda K, Shono T, Hashiguchi K, Yoshida F, Sasaki T
  • Journal Title: J Neurosurg. 112 Pages: 152-157
  • Peer Reviewed
• [Journal Article] Clinical course of abducens nerve palsy associated with skull base tumours. (2009)
  • Author(s): Shono T, Mizoguchi M, Yoshimoto K, Amano T, Natori Y, Sasaki T
  • Journal Title: Acta Neurochir (Wien). 151 Pages: 733-738
  • Peer Reviewed
• [Journal Article] Histological considerations of the cleavage plane for preservation of facial and cochlear nerve functions in vestibular schwannoma surgery. (2009)
  • Author(s): Sasaki T, Shono T, Hashiguchi K, Yoshida F, Suzuki SO
  • Journal Title: J Neurosurg 110 Pages: 648-655
  • Peer Reviewed
• [Journal Article] Prevalence of copy number neutral LOH in glioblastomas revealed by genome-wide analysis of laser-microdissected tissues. (2008)
  • Author(s): Kuga D, Mizoguchi M, Guan Y, Hata N, Yoshimoto K, Shono T, Suzuki SO, Kukita Y, Tahira T, Nagata S, Sasaki T, Hayashi K
  • Journal Title: Neuo-Oncol 10 Pages: 995-1003
  • Peer Reviewed
• [Journal Article] Enhanced expression of NADPH oxidase Nox4 in human gliomas and its roles in cell proliferation and survival. (2008)
  • Author(s): Shono T, Yokoyama N, Uesaka T, Kuroda J, Takeya R, Yamasaki T, Amano T, Mizoguchi M, Suzuki SO, Niiro H, Miyamoto K, Akashi K, Iwaki T, Sumimoto H, Sasaki T
  • Journal Title: Int J Cancer 123 Pages: 787-792
  • Peer Reviewed
• [Journal Article] Narrowing of the regions of allelic losses of chromosome 1p36 in meningioma tissues by an improved SSCP analysis. (2008)
  • Author(s): Guan Y, Hata N, Kuga D, Yoshimoto K, Mizoguchi M, Shono T, Suzuki SO, Tahira T, Kukita Y, Hisaga K, Yokoyama N, Nagata S, Iwaki T, Sasaki T, Hayashi K
  • Journal Title: Int J Cancer 122 Pages: 1820-1826
  • Peer Reviewed
• [Journal Article] Enhanced expression of DNA topoisomerase II genes in human medulloblastoma and its possible association with etoposide sensitivity. (2007)
  • Author(s): Uesaka T, Shono T, Kuga D, Suzuki SO, Niiro H, Miyamoto K, Matsumoto K, Mizoguchi M, Ohta M, Iwaki T, Sasaki T
  • Journal Title: J Neurooncol 84 Pages: 119-129
  • Peer Reviewed
• [Journal Article] Expression of VEGF and its receptor genes in intracranial schwannomas. (2007)
  • Author(s): Uesaka T, Shono T, Suzuki SO, Nakamizo A, Niiro H, Mizoguchi M, Iwaki T, Sasaki T
  • Journal Title: J Neurooncol 83 Pages: 259-266
  • Peer Reviewed
• [Presentation] 小児グリオーマ症例におけるMEPモニタリング下腫瘍摘出術とその長期成績 (2009)
  • Author(s): 庄野禎久, 他
  • Organizer: 第68回日本脳神経外科学会総会
  • Place of Presentation: 東京都
  • Year and Date: 2009-10-15
• [Presentation] Enhanced expression of NADPH oxidase Nox4 in human gliomas and its roles in cell proliferation and survival. (2009)
  • Author(s): Shono T, 他
  • Organizer: The 3rd Quadrennial Meeting of the World Federation of Neuro-Oncology
  • Place of Presentation: 横浜市
  • Year and Date: 2009-05-14
• [Presentation] Enhanced expression of DNA topoisomerase II genes in human medulloblastoma and its possible association with etoposide sensitivity. (2008)
  • Author(s): Shono T, 他
  • Organizer: The 17th International Conference on Brain Tumor Research & Therapy
  • Place of Presentation: 函館市
  • Year and Date: 2008-06-12