2009 Fiscal Year Final Research Report
Elucidation of the role of intramedullary microcirculation in the pathogenesis of syringomyelia and the possibility of a new treatment
| Project/Area Number |
19591692
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
KOYANAGI Izumi Sapporo Medical University, 医学部, 准教授 (40250435)
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| Co-Investigator(Kenkyū-buntansha) |
HOUKIN Kiyohiro 札幌医科大学, 医学部, 教授 (90229146)
AKIYAMA Yukinori 札幌医科大学, 医学部, 研究員 (50404653)
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| Co-Investigator(Renkei-kenkyūsha) |
HONMOU Osamu 札幌医科大学, 神経再生医学講座, 特任教授 (90285007)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 脊髄空洞症 / 髄内微小循環 / 組織間液 |
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| Research Abstract |
Pathogenesis of syringomyelia was studied using experimental models and radiological analysis of clinical cases. The results indicate that the dynamics of extracellular fluid and intramedullary microcirculation plays an important role in development of syringomyelia. In syringomyelia, the increased extracellular fluid state was present around the central canal and the syrinx and spread centrifugally. Such interstitial edema disappeared after treatment of the syrinx. Disturbed absorption of the extracellular fluid through the intramedullary venous system will be the primary mechanism in the pathogenesis of syringomyelia.
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