2009 Fiscal Year Final Research Report
Novel therapeutic strategy by inhibition of multiple signal transduction pathways for malignant gliomas
| Project/Area Number |
19591701
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Kyorin University |
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Principal Investigator |
NAGANE Motoo Kyorin University, 医学部, 准教授 (60327468)
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| Co-Investigator(Kenkyū-buntansha) |
SHIOKAWA Yoshiaki 杏林大学, 医学部, 教授 (20245450)
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| Project Period (FY) |
2007 – 2009
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| Keywords | glioma / 分子標的治療 / シグナル伝達 / アポトーシス / Akt |
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| Research Abstract |
Malignant glioma cells harbor tumor-specific genetic alterations which often activate intracellular signaling pathways, thereby conferring tumor initiation, malignant transformation, and resistance to conventional therapies. Thus, inhibition of such pathways could endow therapeutic benefits. Here we targeted the pathways of PDGFR and/or EGFR in combination with antitumor drugs, resulting in inactivation of their downstream signalings and suppression of tumor growth in human glioma cell lines.
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