2009 Fiscal Year Final Research Report
Mechanism of initiation and development of cerebral aneurysm : Using cerebral aneurysm model
Project/Area Number |
19591705
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Cerebral neurosurgery
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Research Institution | Tokyo Women's Medical University |
Principal Investigator |
KASUYA Hidetoshi Tokyo Women's Medical University, 医学部, 教授 (50169455)
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Co-Investigator(Kenkyū-buntansha) |
YONEYAMA Taku 東京女子医科大学, 医学部, 助教 (90318105)
INOUE Tatsuya 東京女子医科大学, 医学部, 助教 (70398808)
AKAGAWA Hiroyuki 東京女子医科大学, 医学部, 助教 (60398807)
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Project Period (FY) |
2007 – 2009
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Keywords | cerebral aneurysm / subarachnoid hemorrhage / canine / model / initiation / development / rupture |
Research Abstract |
The purpose of this study is to establish cerebral aneurysm model in dogs for the study of initiation and development of cerebral aneurysm. Cerebral aneurysms were induced by the treatment of ligation of the common carotid and renal artery, experimental hypertension and β-aminopropionitrile feeding using eleven dogs. Cerebral angiography was performed every three months till 15 months. One animal in the treated group show saccular cerebral aneurysm visualized by cerebral angiography at basilar bifurcation at three months and gradually developed. Histologically, the aneurysm wall was very thin deposited with fibrinoid, internal elastic lamina became thinner and had splits, and number of smooth muscle cells decreased with disturbed arrangement. Thus, this cerebral aneurysm model is similar to that of human. We would like to continue this work for efficiently producing cerebral aneurysm model in large animal.
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Research Products
(19 results)
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[Journal Article] Cerebral vasospasm following subarachnoid hemorrhage: time for a new world of thought.2009
Author(s)
Pluta RM, Hansen-Schwartz J, Dreier J, Vajkoczy P, Macdonald RL, Nishizawa S, Kasuya H, Wellman G, Keller E, Zauner A, Dorsch N, Clark J, Ono S, Kiris T, Leroux P, Zhang JH
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Journal Title
Neurol Res 31
Pages: 151-158
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[Journal Article] Identification of susceptibility loci for intracranial aneurysm.2008
Author(s)
Bilguvar K, Yasuno K, Niemela M, Ruigrok YM, Fraunberg M, van Duijn CM, van den Berg LH, Mane S, Mason CE, Choi M, Gaal E, Bayri Y, Kolb L, Arlier Z, Ravuri S, Ronkainen A, Tajima A, Laakso A, Hata A, Kasuya H, Breteler MMB, Wijmenga C, State MW, Rinkel GBilguvar K, Yasuno K, Niemela M, Ruigrok YM, Fraunberg M, van Duijn CM, va
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Journal Title
Nature Genet 40
Pages: 1472-1477
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[Journal Article] Systematic screening of lysyl oxidase-like (LOXL) family genes demonstrates that LOXL2 is a susceptible gene to intracranial aneurysms.2007
Author(s)
Akagawa H, Narita A, Yamada H, Tajima A, Krischek B, Kasuya H, Hori T, Kubota M, Saeki N, Hata A, Mizutani T, Inoue I
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Journal Title
Hum Genet 121
Pages: 377-387
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