2009 Fiscal Year Final Research Report
Antineoplastic effect of octacalcium phosphate with osteoconductive characteristics
| Project/Area Number |
19591713
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Tohoku University |
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Principal Investigator |
HATORI Masahito Tohoku University, 大学院・医学研究科, 准教授 (70208552)
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| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Osamu 東北大学, 大学院・歯学研究科, 教授 (60374948)
ITOI Eiji 東北大学, 大学院・医学系研究科, 教授 (80193465)
HOSAKA Masami 東北大学, 大学院・医学系研究科, 助教 (90302124)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 骨・軟部腫瘍学 / 人工骨 |
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| Research Abstract |
The purpose of this study is to evaluate antineoplastic effect of octacalcium phosphate(OCP) with osteoconductive characteristics. EES1, newly-established cell line of Ewing's sarcoma were cultured and evaluated for its growth potential on OCP-coated and hydrolyzate(HL)-coated plates and control.As compared with the control, EES1 growth was suppressed on both OCP-coated and HL-coated plates. C2C12, mouse myoblast cell line was also suppressed on OCP-coated and HL-coated plates. The present study suggests potential application of OCP with various kinds of crystallinity as a bone substitute for the treatment of bone and soft tissue tumors.
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