Spinal cord regeneration with infusion of ch-ABC and transplantation of bone marrow stem cells

2008 Fiscal Year Final Research Report

• Project/Area Number: 19591718
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Nagoya University
• Principal Investigator: MATSUYAMA Yukihiro Nagoya University, 大学院・医学系研究科, 准教授 (20312316)
• Co-Investigator(Kenkyū-buntansha): SAKAI Yoshihito 名古屋大学, 大学院・医学系研究科, 特任講師 (70378107) ; ITO Zenya 名古屋大学, 医学部附属病院, 医員 (50447819) ; IMAGAMA Shiro 名古屋大学, 医学部・附属病院, 医員 (40467288) ; KATAYAMA Ryouji 名古屋大学, 医学部・附属病院, 医員 (40378104)
• Project Period (FY): 2007 – 2008
• Keywords: 脊髄再生 / SSEP / MEP / コンドロイチナーゼABC

Research Abstract

コンドロイチナーゼABCの脊髄損傷後の運動、知覚機能不全の改善作用につき明らかにすることを目的として研究を行った。脊髄損傷後における、脊髄再生において、コンドロイチナーゼABC0.05U/200Lが運動機能回復に置いて至適投与量であった。またこの酵素は脊髄損傷後に発症する痛みにも効果を認める事ができた。現在椎間板ヘルニアにたいしての臨床応用が可能となってきており、脊髄損傷患者にいち早く臨床応用可能と考えている。

Research Products

• [Journal Article] Surgical Results and Related Factors for Ossification of Posterior Longitsudinal Ligament of the Thorachic Spine (2008)
  • Author(s): Morio Matsumoto, Kazuhiro Chiba,Yukihiro Matsuyama
  • Journal Title: Multi Institutional Retrospective Study 33 Pages: 1034-1041
  • Peer Reviewed
• [Journal Article] The effect of Muscle Relaxant on the Paraspinal Muscle Blood Flow (2008)
  • Author(s): Yoshihito Sakai, Yukihiro Matsuyama, Hiroshi Nakamura, Yoshito Ktayama, Shiro Imagama, Zenya Ito, Akira Okamoto
  • Journal Title: 33 Pages: 581-587
  • Peer Reviewed
• [Journal Article] Segmental pedicle screwing for idiopathic scoliosis using computer-assisted surgery (2008)
  • Author(s): Yoshito Sakai, Yukihiro Matsuyama, Hiroshi Nakamura, Yoshito Katayama, Shiro Imagama, Zenya Ito, Naoki Ishiguro
  • Journal Title: J Spinal Disord Tech 21 Pages: 181-186
  • Peer Reviewed
• [Journal Article] Clinical and Radiographic Outcomes of Posterolateral Lumbar Spine Fusion in Humans using Recombinant Human Bone Morphogenetic Protein-2 An Average Five-Year Follow-up Study (2008)
  • Author(s): Yoshito Katayama, Yukihiro Matsuyama, Hisatake Yoshihara, Yoshihito Sakai,Hiroshi Nakamura,Shiro Imagama,Zenya Ito,Norimitsu Wakao,Mitsuhiro Kamiya,YasutsuguYukawa, Tokumi Kanemura, Koji Sato, Hisashi Iwata, Naoki Ishiguro
  • Journal Title: International Orthopaedics (In press)
  • Peer Reviewed
• [Journal Article] Radiographic predictictors for the development of myelopathy in patients with ossification of the posterior longitudinal (2008)
  • Author(s): Shunji Matsunaga,Kozo Nakamura,Atsushi Seich, Yukihiro Matsuyama
  • Journal Title: ligament-A multicenter cohort study 33 Pages: 2648-50
  • Peer Reviewed
• [Journal Article] Chondrotinase ABC enhances axonal regeneration across nerve gaps (2008)
  • Author(s): Tatsuya Hattori, Yukihiro Matsuyama, Yoshihito Sakai, Naoki Ishiguro, Hitoshi Hirata, Ryogo Nakamura
  • Journal Title: J Clin Neurosci 15 Pages: 185-191
  • Peer Reviewed
• [Journal Article] Postoperative changes in spinal cord signal intensity in patients with cervical compression myelopathy : comparison between preoperative and postoperative magnetic resonance images (2008)
  • Author(s): Yasutsugu Yukawa Fumihiko Kato, Keigo Ito, Yumiko Horie,Tetsurou Hida,Masaaki Machino,ZenyaIto,YukihiroMatsuyama
  • Journal Title: J Neurosurg 8 Pages: 524-528
  • Peer Reviewed
• [Journal Article] Analysis of interleukin-8, interleukin-10, and tumor necrosis factor-alpha in the cerebrospinal fluid of patients with cervical spondylotic myelopathy (2008)
  • Author(s): Keigo Ito,Yukihiro Matsuyama, Fumihiko Kato,Naoki Ishiguro
  • Journal Title: J Spinal Disord Tech 21 Pages: 145-7
  • Peer Reviewed
• [Journal Article] Laminoplasty and skip laminectomy for cervical compressive myelopathy : range of motion (2007)
  • Author(s): Yasutsugu Yukawa, Fumihiko Kato, Keigo Ito, Yumiko Horie ,Zenya Ito,Yukihiro Matsuyama
  • Journal Title: postoperative neck pain, and surgical outcomes in a randomized prospective study 32 Pages: 1980 -1985
  • Peer Reviewed
• [Journal Article] Cyclooxygenase-2 expression in ependymoma of the spinal cord (2007)
  • Author(s): Takahiro Naruse, Yukihiro Matsuyama, Naoki Ishiguro
  • Journal Title: Journal of Neurosurgery 6 Pages: 240-246
  • Peer Reviewed
• [Journal Article] Association of Gene polymorphisms with Intervertebral Disc Degeneration and Vertebral Osteoplyte Formation (2007)
  • Author(s): Yoshihito Sakai, Yukihiro Matsuyama, Yukiharu Hasegawa, Hisatake Yoshihara, Hiroshi Nakamura, Yoshito Katayama, Shiro Imagama, Zenya Ito, Naoki Ishiguro, Nobuyuki Hamajima
  • Journal Title: 21 Pages: 1279-86
  • Peer Reviewed
• [Journal Article] New artificial nerve conduits made with photocrosslinked hyaluronic acid for peripheral nerve regeneration (2007)
  • Author(s): Yoshihito Sakai, Yukihiro Matsuyama, Katsuya Takahashi, Tomoya Sato, Tatsuya Hattori, Shojiro Nakashima, Naoki Ishiguro
  • Journal Title: Bio-Medical Materials and Engineering 17 Pages: 191-7
  • Peer Reviewed
• [Presentation] 側彎症手術の術中脊髄モニタリングの実態 : 脊椎脊髄病学会モニタリング委員会による多施設調査 (2008)
  • Author(s): 松山幸弘
  • Organizer: 日本側弯症学会
  • Place of Presentation: 奈良
  • Year and Date: 20081010-1011
• [Presentation] 脊髄モニタリング中にいつ術者にアラームすべきか (2008)
  • Author(s): 伊藤全哉
  • Organizer: 日本側弯症学会
  • Place of Presentation: 奈良
  • Year and Date: 20081010-1011
• [Presentation] 脊椎ナビゲーション手術においてsurface matichingは必要か (2008)
  • Author(s): 酒井義人
  • Organizer: 日本脊椎インストゥルメンテーション学会
  • Place of Presentation: 名古屋
  • Year and Date: 20081002-1003
• [Presentation] 自家腸骨移植と局所骨移植で後方経路腰椎椎体間固定術(PLIF)の椎体間骨癒合に差はあるか (2008)
  • Author(s): 伊藤全哉
  • Organizer: 同一施設による自家腸骨と局所骨の比較検討、日本脊椎インストゥルメンテーション学会
  • Place of Presentation: 名古屋
  • Year and Date: 20081002-1003
• [Presentation] Keratan sulfate is associated with functional disturbance after spinal cord injury (2008)
  • Author(s): Zenya Ito, Kenji Kadomatsu, Yukihiro Matsuyama, Naoki Ishiguro
  • Organizer: Annual Meeting of the Orthopaedic ResearchSociety
  • Place of Presentation: San Francisco
  • Year and Date: 20080302-0305
• [Presentation] Back exercise for the management of flexion and extension-provoked low back pain (2007)
  • Author(s): Yoshihito Sakai, Yukihiro Matsuyama, Hiroshi Nakamura, Yoshito Katayama, Shiro Imagama, Zenya Ito, Naoki Ishiguro
  • Organizer: International Society for the Study of the Lumbar Spine Annual Meeting
  • Place of Presentation: Hong Kong
  • Year and Date: 20070611-0614
• [Presentation] What is the risk factor worsening low back pain (2007)
  • Author(s): Zenya Ito, Yukihiro Matsuyama, Yoshihito Sakai, Hiroshi Nakamura, Shiro Imagama, Noaki Ishiguro, Hasegawa Yukiharu
  • Organizer: A longitudinal study in a year, International Society for the Study of the Lumbar Spine Annual Meeting
  • Place of Presentation: Hong Kong
  • Year and Date: 20070611-0614