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2008 Fiscal Year Final Research Report

The study of coordinated effects between BMP and bisphosphonate in bone remodeling

Research Project

  • PDF
Project/Area Number 19591724
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionOita University

Principal Investigator

KATAOKA Masashi  Oita University, 医学部, 准教授 (40301379)

Project Period (FY) 2007 – 2008
Keywords骨移植 / BMP / ビスホスフォネート / ボーンチャンバー / 血管新生
Research Abstract

BMP単独では骨吸収作用が勝り、骨形成が間に合わない。臨床例においてもBMP使用の失敗例が報告されている。一方BMPとZAを組み合わせると、BMPの骨吸収作用とZAの骨吸収抑制作用がうまく打ち消しあい、かつBMPの骨新生形成作用が働いて、理想的な結果が得られた.

  • Research Products

    (4 results)

All 2008 2007

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (2 results)

  • [Journal Article] Tagil M Manipulating the anabolic and catabolic resp onse in bone graft remodeling : synergism by a combination of local BMP-7 and a single systemic dosis of zoledronate2008

    • Author(s)
      Harding AK, Aspenberg P, Kataoka Mbylski D
    • Journal Title

      J Orthop Res 26(9)

      Pages: 1245-9

    • Peer Reviewed
  • [Journal Article] Total Knee arthroplasty with permanent post-traumatic patellar dislocation2007

    • Author(s)
      Kumagi M, Kataoka M, et.al.
    • Journal Title

      Oitaken seikeigeka igaku kaishi 25

      Pages: 4-8

    • Peer Reviewed
  • [Presentation] ハイドロゲルのBMP徐放担体としての有効性の評価2008

    • Author(s)
      片岡晶志
    • Organizer
      第23回日本整形外科学会基礎学術総会
    • Place of Presentation
      京都
    • Year and Date
      20081023-24
  • [Presentation] ラット移植骨に対するBMP-7、Zoledronic acidの効果の検討2007

    • Author(s)
      片岡晶志
    • Organizer
      第51回日本リウマチ学会総会・学術総会第16回国際リウマチシンポジウム
    • Place of Presentation
      横浜
    • Year and Date
      2007-04-26

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Published: 2010-06-10   Modified: 2016-04-21  

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