2009 Fiscal Year Final Research Report
How dose the alteration in mechanical load due to change of alignment influence articular cartilage of knee joint
| Project/Area Number |
19591733
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Kitasato University |
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Principal Investigator |
URABE Ken Kitasato University, 医学部, 准教授 (90284489)
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| Co-Investigator(Kenkyū-buntansha) |
JINGUSHI Seiya 九州大学, 医学部, 准教授 (80235829)
NARUSE Kouji 北里大学, 医学部, 講師 (60276087)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 四肢機能再建学 |
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| Research Abstract |
It is very important to understand how the alteration in mechanical load due to change of alignment influences articular cartilage of knee joint. In this study we could not establish the animal model that had an onset of osteoarthritis (OA) of knee joint by change of knee alignment. However, we found that OA changes of the patellofemoral joint in STR/OrtCrlj mice that spontaneously developed knee OA may be caused by internal tibial torsion.
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