Involvement of Vascular Endothelial Factor in the remodeling process of Osteoarthritic Cartilage

2008 Fiscal Year Final Research Report

• Project/Area Number: 19591766
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Keio University
• Principal Investigator: ENOMOTO Hiroyuki Keio University, 医学部, 助教 (10256315)
• Co-Investigator(Kenkyū-buntansha): NIKI Yasuo 慶應義塾大学, 医学部, 助教 (10276298)
• Project Period (FY): 2007 – 2008
• Keywords: 変形性膝関節症 / 軟骨 / 血管新生 / 軟骨変性

Research Abstract

変形性関節症(OA)は運動機能低下をきたし、診断と治療の進歩が期待される。我々は血管内皮増殖因子(VEGF)が修復機転である軟骨表層の滑膜性パンヌス下に高発現することを確認した。パンヌスでVEGF受容体が発現していたことから、VEGFが滑膜遊走を促進していることが示唆された。また、VEGF阻害剤は、OAで特徴的な骨棘形成を抑制したことから、変性軟骨の滑膜被覆および骨棘形成における役割が示唆された。

Research Products

• [Journal Article] 変形性膝関節症の軟骨破壊と修復機転におけるプロテアーゼと血管内皮増殖因子の関与 (2008)
  • Author(s): 榎本宏之、Apte SS、岡田保典
  • Journal Title: 別冊整形外科 53 Pages: 42-26
• [Journal Article] Expression of ADAMTS4 (aggrecanase-1) in human osteoarthritic cartilage
  • Author(s): Naito S, Shiomi T, Okada A, Kimura T, Chijiiwa M, Fujita Y, Yatabe T, Komiya K, Enomoto H, Fujikawa K, Okada Y
  • Journal Title: Pathol Int 2007 57(11) Pages: 703-711
• [Journal Article] Serum levels of matrix metalloproteinase-3 (Stromelysin 1) for monitoring synovitis in rheumatoid arthritis
  • Author(s): Kobayashi A, Naito S, Enomoto H, Shiomi T, Kimura T, Obata K, Inoue K, Okada Y
  • Journal Title: Arch Pathol Lab Med 2007 131(4) Pages: 563-570
• [Presentation] Clinical significance of cytokines in synovial fluid as predictive markers of joint destruction (2009)
  • Author(s): Enomoto H, Kobayashi S, Saito S, Momohara S, Niki Y, Inoue K, Toyama Y, Suda Y
  • Organizer: In Annual Meetings of American Academy of Orthopaedic Surgeon
  • Place of Presentation: Las Vegas, USA
  • Year and Date: 2009-02-25
• [Presentation] MT1-MMP regulates collagen fibril growth in tendon and ligament (2009)
  • Author(s): Enomoto H, Vasanji A, Birk D, Apte SS
  • Organizer: In Orthopaedic Research Society
  • Place of Presentation: Las Vegas, USA
  • Year and Date: 2009-02-21
• [Presentation] The evolutionarily conserved, homologous metalloproteases ADAMTS9 and ADAMTS20 cooperate in closure of the mouse secondary palate (2008)
  • Author(s): Enomoto H, Somerville R, Mielke K, Powell Kand Apte SS
  • Organizer: In Orthopaedic Research Society
  • Place of Presentation: San Francisco, USA
  • Year and Date: 2008-03-04