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2008 Fiscal Year Final Research Report

Visible evaluation and pathologic clarification for response at central nervous system and peripheral tissue in arthritis of transgenic animal.

Research Project

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Project/Area Number 19591771
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionUniversity of Occupational and Environmental Health, Japan

Principal Investigator

OHNISHI Hideo  University of Occupational and Environmental Health, Japan, 医学部, 講師 (20279342)

Co-Investigator(Renkei-kenkyūsha) NAKAMURA Toshitaka  産業医科大学, 医学部, 教授 (50082235)
UETA Yoichi  産業医科大学, 医学部, 教授 (10232745)
TANAKA Shinya  産業医科大学, 医学部, 助教 (20412645)
Project Period (FY) 2007 – 2008
Keywords関節炎 / 遺伝子改変動物 / バゾプレッシン / ストレス / 緑色蛍光タンパク
Research Abstract

関節リウマチの動物モデルラットでは、体液を保持する働きがあるホルモンのバソプレシンと新陳代謝の制御や免疫反応に関わるホルモンのコルチコステロンの血液中濃度が上昇した。この機序として、下垂体後葉から分泌されるバソプレシンが、副腎皮質刺激ホルモンの分泌刺激を通してコルチコステロン濃度を上昇させることを、視床下部バソプレシン分泌神経細胞と神経線維が緑色に光る遺伝子を導入したラットを用いて明らかにした。

  • Research Products

    (16 results)

All 2009 2008 2007

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (10 results)

  • [Journal Article] Response of arginine vasopressin-enhanced green fluorescent protein fusion gene in the hypothalamus of adjuvant-induced arthritic rats.2009

    • Author(s)
      Suzuki, H. Onaka, T. Kasai, M. Kawasaki, M. Ohnishi, H. Otsubo, H. Saito, T. Hashimoto,H. Yokoyama, T. Fujihara, H. Dayanithi, G. Murphy, D. Nakamura, T. Ueta Y.
    • Journal Title

      Journal of Neuroendocrinology 21(3)

      Pages: 183-190

    • Peer Reviewed
  • [Journal Article] Adrenomedullin 2 / intermedin-like immunoreactivity in the hypothalamus and brainstem of rats.2008

    • Author(s)
      Hashimoto, H. Kitamura, K. Kawasaki, M. Saito, T. Suzuki, H. Otsubo, H. Ohbuchi, T. Yokoyama, T. Fujihara, H. Takei, Y. Ueta, Y.
    • Journal Title

      Autonomic Neuroscience : Basic and Clinical 139(1-2)

      Pages: 46-54

    • Peer Reviewed
  • [Journal Article] Distribution of orexins-containing fibers and contents of orexins in the rat olfactory bulb.2008

    • Author(s)
      Shibata, M. Mondal, MS. Date, Y. Nakazato, M. Suzuki, H. Ueta, Y.
    • Journal Title

      Neuroscience Research 61(1)

      Pages: 99-105

    • Peer Reviewed
  • [Journal Article] Centrally and peripherally administered ghrelin potently inhibits water intake in rats.2007

    • Author(s)
      Hashimoto, H. Fujihara, H. Kawasaki, M. Saito, T. Shibata, M. Otsubo, H. Takei, Y. Ueta, Y.
    • Journal Title

      Endocrinology 148(4)

      Pages: 1638-1647

    • Peer Reviewed
  • [Journal Article] Adrenomedullin 2 (AM2)/intermedin is a more potent activator of hypothalamic oxytocin-secreting neurons than AM possibly through an unidentified receptor in rats.2007

    • Author(s)
      Hashimoto, H. Hyodo, S. Kawasaki, M. Shibata, M. Saito, T. Suzuki, H. Otsubo, H. Yokoyama, T. Fujihara, H. Higuchi, T. Takei, Y. Ueta, Y.
    • Journal Title

      Peptides 28(5)

      Pages: 1104-1112

    • Peer Reviewed
  • [Journal Article] Downregulation of prolactin-releasing peptide gene expression in the hypothalamus and brainstem of diabetic rats.2007

    • Author(s)
      Mera, T. Fujihara, H. Saito, J. Kawasaki, M. Hashimoto, H. Saito, T. Shibata, M. Onaka, T. Tanaka, Y. Oka, T. Tsuji, S. Ueta, Y.
    • Journal Title

      Peptides 28(8)

      Pages: 1596-1604

    • Peer Reviewed
  • [Presentation] Effects of formalin-induced nociceptive stimulation in the hypothalamus of arginine vasopressin-enhanced green fluorescent protein transgenic rats.2008

    • Author(s)
      Suzuki, H. Kawasaki, M. Ohnishi, H. Otsubo, H. Ohbuchi, T. Hashimoto, H. Yokoyama, T. Fujihara, H. Dayanithi, G. Murphy, D. Nakamura, T. Ueta, Y.
    • Organizer
      Society for Neuroscience Annual Meeting
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      20081115-19
  • [Presentation] Response of arginine vasopressin-enhanced green fluorescent protein fusion gene in the hypothalamus of formalin-induced nociceptive stimulated rats.2008

    • Author(s)
      Suzuki, H. Kawasaki, M. Ohnishi, H. Otsubo, H. Yokoyama, T. Fujihara, H. Dayanithi, G. Murphy, D. Nakamura, T. Ueta, Y.
    • Organizer
      The 3rd Asian Pain Symposium
    • Place of Presentation
      Fukuoka, Japan
    • Year and Date
      20080718-19
  • [Presentation] The expression of the hypothalamic feeding-regulating peptides genes in adjuvant-induced arthritic rats.2008

    • Author(s)
      Suzuki, H. Kasai, M. Kawasaki, M. Ohnishi, H. Otsubo, H. Saito, T. Hashimoto, H. Yokoyama, T. Fujihara, H. Nakamura, T. Ueta, Y.
    • Organizer
      9th International NPY Meeting
    • Place of Presentation
      Okinawa, Japan
    • Year and Date
      20080316-20
  • [Presentation] Response of arginine-enhanced green fluorescent protein fusion gene in the hypothalamus of adjuvant-induced arthritic rats.2007

    • Author(s)
      Suzuki, H. Onaka, T. Kasai, M. Kawasaki, M. Ohnishi, H. Otsubo, H. Fujihara, H. Nakamura, T. Dayanithi, G. Murphy, D. Ueta, Y.
    • Organizer
      Society for Neuroscience 36th Annual Meeting
    • Place of Presentation
      San Diego, California
    • Year and Date
      20071103-07
  • [Presentation] Salusin-b evoked the neurohypophyseal hormone release from the neurohypophysis.2007

    • Author(s)
      Saito, T. Dayanithi, G. Watanabe, T.X. Urabe, T. Hashimoto, H. Suzuki, H. Yokoyama, T. Fujihara, H. Onaka, T. Hirata, Y. Ueta, Y.
    • Organizer
      Society for Neuroscience 36th Annual Meeting
    • Place of Presentation
      San Diego, California
    • Year and Date
      20071103-07
  • [Presentation] バゾプレッシン(AVP)-eGFPトランスジェニックラットを用いたアジュバント関節炎におけるAVPの役割の検討2007

    • Author(s)
      鈴木仁士、尾仲達史、笠井聖仙、川崎展、大西英生、藤原広明、Govindan Dayanithi、David Murphy、中村利孝、上田陽一
    • Organizer
      第58回西日本生理学会
    • Place of Presentation
      福岡
    • Year and Date
      20071019-20
  • [Presentation] 急性浸透圧刺激時のラット下垂体後葉におけるガラニン様ペプチド遺伝子発現2007

    • Author(s)
      川崎展、斎藤淳、橋本弘史、鈴木仁士、大坪広樹、藤原広明、上田陽一
    • Organizer
      第84回日本生理学会
    • Place of Presentation
      大阪
    • Year and Date
      20070320-22
  • [Presentation] アドレノメデュリン2の神経内分泌系への作用のアドレノメデュリンとの比較2007

    • Author(s)
      橋本弘史、兵藤晋、川崎展、斎藤健、大坪広樹、藤原広明、樋口隆、竹井祥郎、上田陽一
    • Organizer
      第84回日本生理学会
    • Place of Presentation
      大阪
    • Year and Date
      20070320-22
  • [Presentation] アジュバント関節炎におけるバゾプレッシン(AVP)の役割 : AVP-eGFPトランスジェニックラットを用いた検討2007

    • Author(s)
      鈴木仁士、尾仲達史、笠井聖仙、川崎展、大西英生、大坪広樹、藤原広明、Govindan Dayanithi、David Murphy、中村利孝、上田陽一
    • Organizer
      第7回日本内分泌学会九州地方会
    • Place of Presentation
      福岡
    • Year and Date
      2007-09-01
  • [Presentation] ラットの中枢および末梢に投与したグレリンの飲水への影響2007

    • Author(s)
      橋本弘史、藤原広明、川崎展、柴田美雅、齋藤健、大坪広樹、竹井祥郎、上田陽一
    • Organizer
      第3回環境生理学プレコングレス
    • Place of Presentation
      大阪
    • Year and Date
      2007-03-19

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Published: 2010-06-10   Modified: 2016-04-21  

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