To clarify the effects of high-fat diet on boon metabolism in ovariectomized mice

2009 Fiscal Year Final Research Report

• Project/Area Number: 19591772
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: University of Occupational and Environmental Health, Japan
• Principal Investigator: TANAKA Shinya University of Occupational and Environmental Health, Japan, 医学部, 講師 (20412645)
• Project Period (FY): 2007 – 2009
• Keywords: 高脂血症

Research Abstract

The high-fat diet increases neuropeptideY mRNA expression in the hypothalamus and peripheral dopaminergic neuron activity and which results in decreases of the cancellous bone and the osteoblastic bone formation and increases in osteoclastic bone resorption in ovariectomized mice in relation with the increased expression of noggin and rankl mRNA in the bone marrow adherent cells.

Research Products

• [Journal Article] Elcatonin injections suppress systemic bone resorption without affecting cortical bone regeneration after drill-hole injuries in mice. (2009)
  • Author(s): Katae Y, Tanaka S, Sakai A, Nagashima M, Hirasawa H, Nakamura T.
  • Journal Title: J Orthop Res 27 Pages: 1652-1658
  • Peer Reviewed
• [Journal Article] The anabolic action of intermittent PTH in combination with cathepsin K inhibitor or alendronate differs depending on the remodeling status in bone in ovariectomized mice. (2009)
  • Author(s): Yamane H, Sakai A, Mori T, Tanaka S, Moridera K, Nakamura T.
  • Journal Title: Bone 44 Pages: 1055-1062
  • Peer Reviewed
• [Journal Article] Genetic disruption of all NO synthase isoforms enhances BMD and bone turnover in mice in vivo: involvement of the renin-angiotensin system. (2008)
  • Author(s): Sabanai K, Tsutsui M, Sakai A, Hirasawa H, Tanaka S, Nakamura E, Tanimoto A, Sasaguri Y, Ito M, Shimokawa H, Nakamura T, Yanagihara N.
  • Journal Title: J Bone Miner Res 23 Pages: 633-643
  • Peer Reviewed
• [Journal Article] Selective cyclooxygenase-2 inhibitor prevents reduction of trabecular bone mass in collagen-induced arthritic mice in association with suppression of RANKL/OPG ratio and IL-6 mRNA expression in synovial tissues but not in bone marrow cells. (2008)
  • Author(s): Taketa T, Sakai A, Tanaka S, Nakai K, Menuki K, Yamane H, Tanaka K, Nakamura T.
  • Journal Title: J Bone Miner Metab 26 Pages: 143-151
  • Peer Reviewed
• [Journal Article] Lower Osteocalcin and osteopontin contents of the femoral head in hip fracture patients than osteoarthritis patients.
  • Author(s): Tanaka S, Narusawa K, Onishi H, Hijioka A, Kanazawa Y, Nishida S, Ikeda S, Nakamura T.
  • Journal Title: Osteoporosis Int (in press)
  • Peer Reviewed
• [Presentation] Pacemaker channel HCN1 affects osteoclast function in vitro and bone remodeling in vivo (2009)
  • Author(s): Notomi T, Tanaka S, Amano T, Nakamura T, Noda M, Skerry T, Kuno M
  • Organizer: 31st Annual Meeting of the American Society for Bone and Mineral Research
  • Place of Presentation: Denver
  • Year and Date: 20090911-20090915
• [Presentation] ペースメーカーチャネル(HCN1)の破骨細胞機能と骨代謝機構への関与. (2009)
  • Author(s): 納富拓也, 田中伸哉, 天野均, 中村利孝, 野田政樹, 久野みゆき
  • Organizer: 第27回日本骨代謝学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 20090723-20090725
• [Presentation] High-fat diet facilitated decreases in BMD of ovariectmized mice and suppressed the anabolic effects of PTH on bone. (2008)
  • Author(s): Tanaka S, Sakai A, Tanigawa T, Hirasawa H, Katae Y, Tanaka K, Nakamura
  • Organizer: 30th annual meeting of American Society for Bone and Mineral Research
  • Place of Presentation: Montreal
  • Year and Date: 20080912-20080916
• [Presentation] 卵巣摘除マウスに対する高脂質食投与は骨塩量低下を促進しPTH間歇投与による骨量増加効果を抑制する. (2008)
  • Author(s): 田中伸哉, 酒井昭典, 谷川隆久, 平澤英幸, 片江祐二, 田中和広, 土屋卓人, 中村利孝
  • Organizer: 第28回日本骨形態計測学会
  • Place of Presentation: 東京
  • Year and Date: 2008-07-27