2009 Fiscal Year Final Research Report

Novel mechanisms for neuroprotective actions of erythropoietin

Research Project

Project/Area Number	19591813
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Anesthesiology/Resuscitation studies
Research Institution	Yokohama City University
Principal Investigator	ANDOH Tomio Yokohama City University, 大学院・医学研究科, 客員教授 (00193110)
Co-Investigator(Kenkyū-buntansha)	MIZUNO Yusuke 横浜市立大学, 大学院・医学研究科, 助教 (80433192) ECHIGO Noriyuki 横浜市立大学, 附属病院, 准教授 (00363797) KAMIYA Yoshitaka 横浜市立大学, 大学院・医学研究科, 助教 (90381491)
Project Period (FY)	2007 – 2009
Keywords	神経保護 / エリスロポエチン / イオンチャネル / 細胞内カルシウム濃度
Research Abstract	We found that Epo increased the intracellular Ca^<2+> concentration ([Ca^<2+>]I) in primary cortical cultures in the normal condition but decreased the elevated [Ca^<2+>]i in the excitotoxic condition. The Epo-induced increase involved Ca^<2+> influx through voltage-dependent Ca channels, whereas the Epo-induced decrease involved PI3 kinase-dependent activation of BK type Ca-activated K channels, at least in part. The pathophysiological significance of our findings needs to be investigated in further studies.

(4 results)