2009 Fiscal Year Final Research Report
Novel mechanisms for neuroprotective actions of erythropoietin
| Project/Area Number |
19591813
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Yokohama City University |
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Principal Investigator |
ANDOH Tomio Yokohama City University, 大学院・医学研究科, 客員教授 (00193110)
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| Co-Investigator(Kenkyū-buntansha) |
MIZUNO Yusuke 横浜市立大学, 大学院・医学研究科, 助教 (80433192)
ECHIGO Noriyuki 横浜市立大学, 附属病院, 准教授 (00363797)
KAMIYA Yoshitaka 横浜市立大学, 大学院・医学研究科, 助教 (90381491)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 神経保護 / エリスロポエチン / イオンチャネル / 細胞内カルシウム濃度 |
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| Research Abstract |
We found that Epo increased the intracellular Ca^<2+> concentration ([Ca^<2+>]I) in primary cortical cultures in the normal condition but decreased the elevated [Ca^<2+>]i in the excitotoxic condition. The Epo-induced increase involved Ca^<2+> influx through voltage-dependent Ca channels, whereas the Epo-induced decrease involved PI3 kinase-dependent activation of BK type Ca-activated K channels, at least in part. The pathophysiological significance of our findings needs to be investigated in further studies.
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